Perphenazine/Amitriptyline (not available in Canada) is used for the treatment of moderate to severe depression with moderate to severe anxiety. It is also used to treat anxiety due to other mental disorders.

Do not take Perphenazine/Amitriptyline (not available in Canada) if you are allergic to any ingredient in Perphenazine/Amitriptyline (not available in Canada) or to similar medications you have a blood disorder you are recovering from a recent heart attack you have a decreased ability to fight infection in addition to a lack of energy and anemia you have brain or liver damage you are currently taking monoamine oxidase (MAO) inhibitors or have taken them within the past 14 days you are taking elective surgery

Before using Perphenazine/Amitriptyline (not available in Canada), tell your health care provider about any of the following: if you are pregnant, plan on becoming pregnant, or breastfeeding if you are taking any prescription or nonprescription medicine if you have a history of addiction to other medicines if you have ever tried or seriously considered suicide if you are undergoing electroshock therapy if you have any other medical condition

Other:  Sensitivity to sunlight. Perphenazine/Amitriptyline (not available in Canada) may be habit-forming. Withdrawal symptoms (such as convulsions, tremor, stomach and muscle cramps, vomiting, and sweating) may occur in patients who suddenly stop taking Perphenazine/Amitriptyline (not available in Canada). Your doctor will gradually reduce the amount of Perphenazine/Amitriptyline (not available in Canada).

How much medicine you take and how often you take it depends on many factors, including the condition being treated and the age and weight of the patient. If you have any questions about the amount and/or frequency of Perphenazine/Amitriptyline (not available in Canada) you are taking, talk with your health care provider. Do not drink alcohol or take other mental depressants (eg, antihistamines, narcotics) while taking Perphenazine/Amitriptyline (not available in Canada). Perphenazine/Amitriptyline (not available in Canada) may cause drowsiness or dizziness. Use caution while driving or performing other tasks requiring alertness, coordination, or physical dexterity. Neuroleptic malignant syndrome (NMS) is a potentially deadly syndrome associated with Perphenazine/Amitriptyline (not available in Canada). Talk with your doctor if the following symptoms develop: Increased body heat; muscle rigidity; altered mental state (eg, confusion, withdrawal, unresponsiveness); irregular pulse and blood pressure; increased heart rate; sweating. Involuntary and uncontrollable movements may develop in patients treated with Perphenazine/Amitriptyline (not available in Canada). It occurs most often in the elderly; the risk of the symptoms becoming permanent increases with long-term use and with high doses. However, it is possible to develop these symptoms after short-term treatment at low doses. This syndrome is normally identified by rhythmical, involuntary movements of the tongue, face, mouth,, or jaw (eg, tongue sticking out, puffing of cheeks, puckering of mouth, chewing movements), sometimes with involuntary movements of the arms or legs. Small worm-like movements of the tongue may be an early sign of the syndrome. If Perphenazine/Amitriptyline (not available in Canada) is stopped at this time, the syndrome may not develop. There is no known treatment of this syndrome, although it may stop, either partially or completely, if Perphenazine/Amitriptyline (not available in Canada) is withdrawn. Do not use Perphenazine/Amitriptyline (not available in Canada) in combination with MAO inhibitors or within 14 days of stopping treatment with an MAO inhibitor. After stopping Perphenazine/Amitriptyline (not available in Canada), wait at least 14 days before starting an MAO inhibitor. Perphenazine/Amitriptyline (not available in Canada) may cause sensitivity to sunlight. Do not expose yourself for long periods of time to the sun. Wear sunscreens and wear protective clothing until tolerance is determined. Talk with your doctor if you notice a rise in body temperature (fever). This may suggest that you cannot tolerate Perphenazine/Amitriptyline (not available in Canada). Do not stop taking Perphenazine/Amitriptyline (not available in Canada) without checking with your doctor. Patients with previous medical conditions should talk with their health care provider before taking Perphenazine/Amitriptyline (not available in Canada). Do not take more medicine than is prescribed unless advised to do so by your doctor or health care provider. Do not take any other over-the-counter or prescription medications without talking with your doctor. If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your doctor. If more than one dose is missed, contact your doctor or pharmacist.

Store Perphenazine/Amitriptyline (not available in Canada) at controlled room temperature (36 to 77 degrees F). Keep tightly closed. Protect from light and moisture.