Drops - Dispensed in a unique, 2-chambered vial sy

Merck Frosst

Timpilo (pilocarpine/timolol) is used for the reduction of intra-ocular pressure (eye pressure) in glaucoma.

Do not take Timpilo (pilocarpine/timolol) if you are allergic to any ingredient in Timpilo (pilocarpine/timolol), if you have malignant glaucoma, peripheral anterior synechia, trauma, acute-inflammatory disease of anterior chamber, glaucoma occurring or persisting after extracapsular cataract extraction when posterior synechia may occur if you have bronchospasm, including bronchial asthma, or a history of these conditions, or chronic obstructive pulmonary disease if you have sinus bradycardia, second and third degree atrioventricular block, overt congestive cardiac failure, cardiogenic shock

Before using Timpilo (pilocarpine/timolol), tell your health care provider about any of the following: if you are pregnant, planning to become pregnant, or breastfeeding if you are taking any other prescription medicine, nonprescription medicine, herbal preparation, or dietary supplement if you have impaired kidney or liver function, if you have heart or lung problem if you have high blood pressure if you have choroidal detachment or or difficulty to adapt in the dark if you wear contact lenses if you have diabetes, thyrotoxicosis ot muscle weakness if you use another beta-adrenergic blocking agent, calcium channel blockers or catecholamine-depleting drugs,.

Timpilo (pilocarpine/timolol) should be used with caution in patients with diabetes, especially labile diabetes. Following administration of Timpilo (pilocarpine/timolol), severe respiratory reactions and cardiac reactions have been reported, including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure.

Other: Ringing in the ears, headache, asthenia, fatigue, chest pain, alopecia, psoriasiform rash or exacerbation of psoriasis, dizziness, depression, increase in signs and symptoms of myasthenia gravis, insomnia, nightmares, memory loss, paresthesia, dec

How much medicine you take and how often you take it depends on many factors, including the condition being treated and the age and weight of the patient. If you have any questions about the amount and/or frequency of Timpilo (pilocarpine/timolol) you are taking, talk with your health care provider. There have been reports of inadvertent overdosage with Timoptic resulting in systemic effects similar to those seen with systemic beta-adrenergic blocking agents such as dizziness, headache, shortness of breath, bradycardia, bronchospasm, and cardiac arrest. The following therapeutic measures should be considered: 1) Gastric lavage: If ingested. 2) Symptomatic bradycardia: Use atropine sulfate i.v. in a dosage of 0.25 to 2 mg to induce vagal blockade. If bradycardia persists, i.v. isoproterenol HCl should be administered cautiously. In refractory cases the use of a transvenous cardiac pacemaker may be considered. 3) Hypotension: Use sympathomimetic pressor drug therapy, such as dopamine, dobutamine or norepinephrine. In refractory cases the use of glucagon HCl has been reported to be useful. 4) Bronchospasm: Use isoproterenol HCl. Additional therapy with aminophylline may be considered. 5) Acute cardiac failure: Conventional therapy with digitalis, diuretics and oxygen should be instituted immediately. In refractory cases the use of i.v. aminophylline is suggested. This may be followed if necessary by glucagon HCl which has been reported to be useful. 6) Heart block (second-or-third degree): Use isoproterenol HCl or a transvenous cardiac pacemaker. If accidentally swallowed, pilocarpine is readily absorbed from the alimentary tract, and if a large amount is ingested cholinergic symptoms may appear, including salivation, lacrimation, nausea, vomiting, headache, mental confusion, visual disturbances, abdominal colic, diarrhea, bronchospasm and hypotension. Dehydration and shock may develop. Respiratory depression has been reported in severe cases of pilocarpine poisoning. Do not take any other over-the-counter or prescription medications without talking with your health care provider. If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. If more than one dose is missed, contact your health care provider or pharmacist.

Prior to mixing solutions, avoid temperatures above 30°C. After mixing, Timpilo (pilocarpine/timolol) is stable for 28 days when Store Timpilo (pilocarpine/timolol)d at room temperature. Protect from light and freezing.