What is Serzone/Nefazodone used for?

This medicine is used to treat depression.

How should Serzone/Nefazodone be stored?

Store below 104 degrees F. Keep in a tight container.

General drug information:

When should Serzone/Nefazodone not be taken?

Do not take this medicine if you are allergic to any ingredient in this medicine or to similar medications you are taking terfenadine, astemizole, pimozide, carbamazepine, or triazolam while taking this medicine you stopped taking this medicine previously due to liver injury

What precautions should I follow when taking Serzone/Nefazodone?

Before using this medicine, tell your health care provider about any of the following: if you are pregnant, planning to become pregnant, or breastfeeding if you are taking any prescription medicine, nonprescription medicine, herbal preparation, or dietary supplement if you have a history of heart attack if you have heart or brain disease if you have a history of mania if you have thoughts of suicide if you have a history of seizures if you have liver problems, including cirrhosis if you have a history of substance abuse if you are currently taking or have taken a monoamine oxidase (MAO) inhibitor within the last 14 days if you have any other medical condition

What special warning(s) should I be aware of when taking Serzone/Nefazodone?

Life-threatening liver failure can occur in patients who are taking this medicine. Contact your doctor at once if you experience yellowing of the skin or eyes, loss of appetite, stomach upset or general body discomfort.

What are the side effects of Serzone/Nefazodone?

Most severe:  Painful, prolonged erections; yellowing of the skin or eyes; loss of appetite; upset stomach; general body discomfort; seizures; fainting.

Most common:  Drowsiness; dry mouth; nausea; dizziness; weakness; constipation; lightheadedness; confusion; blurred vision; abnormal vision; headache; infection (fever, chills, sore throat); flu syndrome; chills; fever; rash; itching; indigestion; diarrhea; increased appetite; vomiting; swelling of the hands and feet; memory loss; abnormal skin sensations; abnormal dreams; decreased concentration; incoordination; tremor; sore throat; decreased sex drive; increased cough; ringing in the ears; changes in taste; frequent urination; urinary tract infection; urinary retention; vaginal infection; sleeplessness.

Other:  Rigid neck; stiff muscles; thirst; joint pain; breast pain.

How should I take Serzone/Nefazodone?

How much medicine you take and how often you take it depends on many factors, including the condition being treated and the age and weight of the patient. If you have any questions about the amount and/or frequency of the medicine you are taking, talk with your health care provider. Carefully read the patient leaflet provided with this medicine and reread it each time you get this prescription refilled. Take this medicine exactly as prescribed by your health care provider. Stop using this medicine and contact your health care provider at once if any of the following occur: Yellowing of the skin or eyes; loss of appetite; upset stomach; general body discomfort. Contact your doctor if you develop a rash, hives, or other signs of an allergic reaction while taking this medicine. Men -- Stop taking this medicine and contact your health care provider at once if painful or prolonged erection occurs. If the condition lasts for more than 24 hours, seek immediate medical attention. Contact your doctor at once if you notice any changes in vision. This medicine may cause dizziness, drowsiness, or blurred vision. Use caution while driving or performing other tasks requiring mental alertness, coordination, and dexterity. Avoid drinking alcohol while taking this medication. Do not take this medicine if you are currently taking or have taken an MAO inhibitor within the last 2 weeks. Do not take MAO inhibitors for at least 7 days after stopping this medication. If you are uncertain whether your other medications contain an MAO inhibitor, check with your health care provider. Do not stop taking this medication without checking with your health care provider. Continue to take it even though you feel better. Patients with previous medical conditions should talk with their health care provider before taking this medication. Do not take any other over-the-counter or prescription medications without talking with your health care provider. This includes any herbal preparations or dietary supplements. Do not take more medication than prescribed unless advised to do so by your doctor or health care provider. Contact your health care provider at once if you feel you have taken too much of this medicine. If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your doctor. If more than one dose is missed, contact your doctor or pharmacist.