Description
Indications
Amlodipine, valsartan, and hydrochlorothiazide is a combined medication regimen used for the treatment of hypertension, or high blood pressure. Hypertension imposes an increased workload on the heart and arteries, which, if sustained over an extended period, can impair their proper functioning. This may result in damage to the blood vessels in vital organs such as the brain, heart, and kidneys, leading to conditions such as heart failure or kidney failure.
Amlodipine functions as a calcium channel blocker (CCB), exerting its effects by modulating the movement of calcium into the cells of the heart and blood vessels. Valsartan, on the other hand, operates as an angiotensin II receptor blocker (ARB) by blocking a substance within the body that constricts blood vessels. Hydrochlorothiazide, classified as a thiazide diuretic (water pill), aids in reducing water retention by enhancing urine flow. This diuretic action contributes to lowering blood pressure levels.
Uses and Dosage
Follow your doctor’s instructions when taking this medication orally, either with or without food. Typically, it is taken once daily. If you consume this medication too close to your bedtime, you may experience the need to wake up during the night to urinate. Take this medication at least 4 hours before your intended bedtime.
The appropriate dosage of this medication will depend on your medical condition and how you respond to the treatment.
For optimal results, take this medication consistently at the same time each day. This will help you remember to take it regularly. It may take up to 2 weeks before you experience the full benefits of this product.
Continue taking this medication even if you feel well, as many individuals with high blood pressure do not exhibit symptoms of illness.
If you are also taking specific medications to lower your cholesterol, such as bile acid-binding resins like cholestyramine or colestipol, make sure to take amlodipine/valsartan/hydrochlorothiazide at least 4 hours before or 4 to 6 hours after these cholesterol-lowering medications.
Inform your doctor if your condition does not improve or if it worsens, such as if your blood pressure readings remain elevated or increase.
Side Effects
Some side effects may occur that usually do not need medical attention:
- dizziness
- spinning sensation, or lightheadedness as your body adjusts to the medication
Inform your healthcare provider immediately if you experience any serious side effects:
- bloating or swelling of the face, arms, hands, lower legs, or feet
- rapid weight gain
- tingling of the hands or feet
- unusual weight gain or loss
- body aches or pain
- chills
- cough
- difficulty with breathing
- ear congestion
- fever
- headache
- loss of voice
- muscle aches
- sneezing
- sore throat
- stuffy or runny nose
- unusual tiredness or weakness
Caution
Prior to initiating treatment with this product, disclose any known allergies to amlodipine, valsartan, or any other substances to your healthcare provider or pharmacist. Inactive ingredients present in this product may trigger allergic reactions or other adverse effects.
Before commencing the use of this medication, inform your doctor or pharmacist about your complete medical history, particularly if you have a history of liver disease, aortic stenosis (a specific heart valve condition), dehydration, or elevated levels of potassium in your blood.
The consumption of this drug may induce dizziness. Consumption of alcohol or marijuana can exacerbate this dizziness. Refrain from driving, operating machinery, or engaging in activities that require alertness until you can safely do so.
Excessive sweating, diarrhea, or vomiting may lead to feelings of lightheadedness. Notify your doctor if you experience prolonged episodes of diarrhea or vomiting.
This product has the potential to increase potassium levels in your body. Prior to using potassium supplements or salt substitutes containing potassium, seek guidance from your doctor or pharmacist.
Elderly individuals may be more susceptible to the side effects of this drug, particularly dizziness and alterations in urine output (indicative of kidney problems).
Inform your doctor if you are pregnant or planning to conceive. Pregnancy should be avoided while using this medication, as valsartan may pose risks to the unborn baby. If you become pregnant, promptly discuss the risks and benefits of this medication with your doctor.
The transfer of valsartan into breast milk is uncertain, while amlodipine is known to pass into breast milk. Consult your doctor before breastfeeding while using this medication.
Form and Strength
Exforge HCT is available in the following forms and strengths:
-
Exforge HCT (form):
- 5/160/12.5mg
- 10/320/25mg
FAQ
How long does it take for Exforge to lower blood pressure?
The full blood pressure lowering effect was achieved 2 weeks after being on the maximal dose of Exforge.
What’s the best time of day to take Exforge?
The effects of Exforge last 24 hours, so the precise time of day you take it might not matter too much. The most important thing is to take Exforge consistently at the same time every day.
Resources
- https://www.novartis.com/us-en/sites/novartis_us/files/exforge_hct.pdf
- https://www.goodrx.com/exforge/what-is#faqs
- https://www.rxlist.com/exforge-hct-drug.htm
- https://www.webmd.com/drugs/2/drug-152359/exforge-hct-oral/details
- https://www.mayoclinic.org/drugs-supplements/amlodipine-valsartan-and-hydrochlorothiazide-oral-route/description/drg-20072966
- https://www.drugs.com/exforge-hct.html