Prescription Required 
Formulation : 
Description
Indications
Danazol is prescribed for women to address pelvic pain and infertility caused by endometriosis, as well as to alleviate breast pain, tenderness, and nodules associated with fibrocystic breast disease. It is additionally utilized in both men and women to prevent swelling in the abdomen, arms, legs, face, and airway stemming from a congenital disease called hereditary angioedema.
Danazol, an androgen resembling testosterone, operates by reducing the production of hormones by the ovaries, which typically exacerbate the conditions of endometriosis and fibrocystic breast disease. In the case of angioedema treatment, danazol aids in increasing the levels of a specific protein within the body’s immune system.
Uses and Dosage
Danazol is administered in capsule form for oral consumption. Typically, it is taken twice daily for endometriosis or fibrocystic breast disease, and two or three times a day for hereditary angioedema.
Follow the prescribed dosage precisely; refrain from taking more or less than instructed, and avoid exceeding the recommended frequency.
Do not discontinue danazol without consulting your doctor. If you are dealing with fibrocystic breast disease, you can anticipate an improvement in breast pain and tenderness within the first month of taking danazol, with these symptoms typically resolving after 2 to 3 months of treatment. Likewise, breast lumps are expected to show improvement after 4 to 6 months of consistent treatment.
Side Effects
Some side effects may occur that usually do not need medical attention:
- acne
- decrease in breast size
- weight gain
- oily skin or hair
- flushing
- sweating
- vaginal dryness, burning, itching, or bleeding
- nervousness
- irritability
Inform your healthcare provider immediately if you experience any serious side effects:
- deepening of voice
- hoarseness, sore throat
- increase in facial hair
- baldness
- swelling of the arms or legs (in women)
- red, peeling, or blistering skin
Caution
- Before initiating danazol, inform your doctor or pharmacist about any allergies you may have, as this medication could contain inactive ingredients that may trigger allergic reactions or other complications.
- Prior to commencing this medication, disclose your medical history to your doctor or pharmacist, particularly if you have a history of heart or blood vessel disease, hypertension, diabetes, high cholesterol levels, breast cancer, liver disease, kidney disease, seizures, migraine headaches, unusual vaginal bleeding, or certain blood disorders (porphyria, polycythemia).
- This medication may have an impact on sperm; consult your doctor for further details.
- Danazol must not be used during pregnancy, as it poses a risk of harm to the unborn baby. If you become pregnant or suspect that you may be pregnant, promptly inform your doctor.
- The passage of this medication into breast milk is uncertain. Due to potential risks to the infant, avoid breastfeeding while using this medication.
Form and Strength
Danocrine is available in the following forms and strengths:
- Danocrine tablet:
- 50 mg
- 100 mg
- 200 mg
- danazol capsule:
- 50 mg
- 100 mg
- 200 mg
FAQ
Why is Danocrine not considered a first-choice treatment for endometriosis?
Although Danocrine works well to lessen pain caused by endometriosis, it has some side effects that are hard to tolerate, such as acne, muscle cramps, swelling, deeper voice, hair growth, and weight gain.
Does Danocrine raise testosterone levels?
Yes, it raises free testosterone in the body which is why it can cause some side effects such as acne, muscle cramps, swelling, deepening of voice, and hair growth.
