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Formulation : 
Description
Indications
Tranylcypromine is employed for alleviating depression in individuals who have not experienced positive outcomes with alternative medications. Belonging to the category of medications known as monoamine oxidase inhibitors (MAOIs), tranylcypromine functions by elevating the levels of specific natural compounds crucial for sustaining mental equilibrium.
Uses and Dosage
Tranylcypromine is available in tablet form for oral ingestion and is typically taken twice a day. Maintain consistency by consuming tranylcypromine at approximately the same times each day. Ensure that you adhere precisely to the prescribed instructions.
Be aware that tranylcypromine might lead to habit-forming tendencies. Refrain from exceeding the prescribed dose, altering the frequency, or extending the duration of use without your doctor’s guidance. If you notice an inclination to take extra doses or observe unusual changes in behavior or mood, contact your doctor.
Your doctor will most likely initiate your treatment with a low tranylcypromine dose and gradually increase it, no more frequently than once every 1-3 weeks. Once your symptoms improve, your doctor will likely guide you through a gradual reduction in the dose.
Tranylcypromine effectively manages depression symptoms, though it does not provide a complete cure. It might take up to 3 weeks or more for you to experience the full therapeutic effects of tranylcypromine. Even if you start feeling better, continue taking tranylcypromine. Refrain from discontinuing its use without consulting your doctor. If discontinuation becomes necessary, your doctor will probably recommend a gradual reduction of the dose.
Side Effects
Some side effects may occur that usually do not need medical attention:
- drowsiness
- weakness
- dry mouth
- loss of appetite
- diarrhea
- constipation
- stomach pain
- blurred vision
- chills
- ringing in the ears
- muscle tightening or jerking
- uncontrollable shaking of any part of the body
- numbness, burning, or tingling in the arms or legs
- difficulty urinating
- decreased sexual ability
- hair loss
- rash
Inform your healthcare provider immediately if you experience any serious side effects:
- headache
- slow, fast, or pounding heartbeat
- chest pain or tightness
- tightening of the throat
- nausea
- sweating
- fever
- cold, clammy skin
- dizziness
- neck stiffness or soreness
- sensitivity to light
- widened pupils (black circles in the middle of the eyes)
- swelling of arms, hands, feet, ankles, or lower legs
- unusual bleeding or bruising
- pain in the upper right part of the stomach
- flu-like symptoms
- yellowing of the skin or eyes
Caution
Prior to beginning tranylcypromine, inform your doctor or pharmacist about any allergies you might have, including allergies to tranylcypromine itself. This product may contain inactive components capable of triggering allergic reactions or other complications.
Before initiating this medication, disclose your medical history to your doctor or pharmacist, particularly if you have a specific type of adrenal gland tumor (pheochromocytoma), a history of cerebrovascular disease like stroke, high blood pressure, heart issues, frequent or severe headaches, mental or mood disorders, liver disorders, kidney disease, certain nervous system conditions, overactive thyroid (hyperthyroidism), or a personal/family history of angle-closure glaucoma.
This drug can lead to dizziness or drowsiness. Consumption of alcohol or marijuana can exacerbate these effects. Refrain from engaging in activities requiring alertness until you can do so safely.
For individuals with heart disease, this medication might mask chest pain. During the course of this treatment, avoid strenuous exercise.
For those with diabetes, tranylcypromine could lower blood sugar levels. Regularly monitor your blood sugar and share the results with your doctor. Should you experience symptoms of low blood sugar such as sudden sweating, trembling, rapid heartbeat, increased hunger, blurry vision, dizziness, or tingling in your extremities, promptly inform your doctor. It might be necessary to adjust your diabetes medication, exercise routine, or dietary plan.
In the elderly, the side effects of this medication, particularly those related to blood pressure, might be more pronounced.
During pregnancy, this medication should be used only if absolutely essential. Discuss the potential risks and benefits with your doctor.
Given that untreated mental/mood disorders (like depression) can be serious, do not cease taking this medication unless specifically instructed by your doctor. If you are considering pregnancy, become pregnant, or suspect you might be pregnant, promptly discuss with your doctor the advantages and potential risks associated with using this medication during pregnancy.
This medication enters breast milk. Consult your doctor prior to breastfeeding.
Form and Strength
Parnate is available in the following forms and strengths:
-
Parnate tablet:
- 10mg
FAQ
How long does it take for Parnate to work?
It can take 2 to 4 weeks before you feel the effects of Parnate.
What foods should be avoided with Parnate?
Limit foods that have been fermented, aged, pickled, or smoked. These foods have high tyramine levels and can raise your risk for dangerously high blood pressure if you eat them while taking Parnate.
Resources
- https://www.goodrx.com/tranylcypromine/what-is#faqs
- https://www.mayoclinic.org/drugs-supplements/tranylcypromine-oral-route/side-effects/drg-20073226?p=1
- https://www.webmd.com/drugs/2/drug-6965/parnate-oral/details
- https://medlineplus.gov/druginfo/meds/a682088.html
- https://www.drugs.com/mtm/parnate.html#:~:text=Parnate%20is%20a%20monoamine%20oxidase,medicines%20have%20not%20been%20effective
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