Actoplus Met (Pioglitazone/Metformin) Customer Reviews

Actoplus Met

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Generic alternative for Actoplus Met


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This combination medication is prescribed alongside a balanced diet and exercise regimen to manage elevated blood sugar levels in individuals with type 2 diabetes. The effective control of high blood sugar can reduce the risk of kidney damage, vision impairment, nerve complications, amputation, and sexual function issues.

Metformin reduces the amount of sugar generated by your liver and absorbed by your stomach and intestines. Pioglitazone belongs to a category of medications referred to as thiazolidinediones or “glitazones.” Metformin and pioglitazone function by assisting in the restoration of your body’s natural response to the insulin it produces.

Uses and Dosage

Follow your doctor’s instructions when taking this medication by mouth, typically once or twice daily with meals to minimize the likelihood of stomach discomfort. Ensure you stay well-hydrated while on this medication unless otherwise advised by your healthcare provider.

The prescribed dosage is determined by your medical condition, how you respond to treatment, and any other medications you might be using. Inform your doctor and pharmacist about all the products you use, including prescription drugs, over-the-counter medications, and herbal supplements. To minimize the risk of side effects, particularly stomach upset, your doctor may recommend initiating this medication at a low dose and gradually increasing it. Adhere to your doctor’s instructions diligently.

To maximize the benefits of this medication, take it consistently at the same time(s) every day.

If you are already on another diabetes medication, carefully follow your doctor’s guidance for discontinuing or continuing the previous drug while starting this one.

As directed by your doctor, regularly monitor your blood sugar levels. Keep a record of the results and share them with your healthcare provider. Inform your doctor if your blood sugar levels are excessively high or low, as your dosage or treatment plan may need adjustment. It may take approximately 2 to 3 months before experiencing the full effects of this medication.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • body aches or pain
  • cough
  • ear congestion
  • fever
  • loss of voice
  • runny or stuffy nose
  • sneezing
  • sore throat

Inform your healthcare provider immediately if you experience any serious side effects:

  • bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • swelling of the face, fingers, feet, or lower legs
  • weight gain
  • pain or swelling in the arms or legs without any injury
  • pale skin
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness


Before initiating this medication, please inform your healthcare provider or pharmacist of any allergies you may have, particularly to pioglitazone or metformin. This product may contain inactive ingredients that can trigger allergic reactions or other complications.

Prior to using this medication, discuss your medical history with your doctor or pharmacist, especially if you have a history of severe respiratory issues, blood disorders, kidney or liver disease, heart conditions, pulmonary fluid accumulation, edema (swelling), a specific eye condition known as macular edema, or a history of bladder cancer.

Low or high blood sugar levels may lead to symptoms like blurred vision, dizziness, or drowsiness. Refrain from activities requiring alertness or clear vision, such as driving or operating machinery, until you are confident in your ability to perform them safely.

While taking this medication, it is advisable to limit alcohol consumption, as it can increase the risk of lactic acidosis and hypoglycemia (low blood sugar).

Instances of dehydration, which can elevate the risk of lactic acidosis, may arise from a high fever, diuretic use, excessive sweating, diarrhea, or vomiting. Should you experience prolonged diarrhea or vomiting, discontinue use of this medication and promptly inform your doctor. Ensure adequate fluid intake unless instructed otherwise by your healthcare provider.

Maintaining blood sugar control may be more challenging during periods of physical stress, such as fever, infection, injury, or surgery. Consult your doctor, as increased stress may necessitate adjustments to your treatment plan, medications, or blood sugar monitoring.

Pioglitazone may raise the risk of bone fractures in women, typically affecting the upper arm, hand, or foot.

Older adults may be at an increased risk of experiencing side effects, such as hypoglycemia or lactic acidosis.

During pregnancy, consider using this medication only when absolutely necessary, and discuss its potential benefits and risks with your healthcare provider. In some cases, your doctor may recommend using insulin rather than this product during pregnancy, so follow their guidance closely.

This medication can influence the menstrual cycle and elevate the likelihood of pregnancy. Consult your doctor or pharmacist regarding the use of reliable birth control methods while taking this medication.

Metformin may pass into breast milk in small amounts, although it remains unclear whether pioglitazone is excreted in breast milk. Seek your doctor’s counsel before breastfeeding while using this medication.

Form and Strength

Actoplus Met is available in the following forms and strengths:

  • Actoplus Met tablet:

    • 15/850mg
  • metformin and pioglitazone tablet:

    • 15/500mg
    • 15/850mg


How long does it take for Actos Met to start working?

Actos Met begins working as soon as you take a dose. But it can take up to several weeks before you notice beneficial changes in your blood sugar level.

Can you take Actoplus Met without a meal?

It’s best to take Actoplus Met with food to prevent stomach upset. You are more likely to experience nausea and diarrhea when taking it without meals.



Additional information

Generic name:





15/500mg, 15/850mg

Quantities Available:

56, 90, 100, 112, 180

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Actoplus Met (Pioglitazone/Metformin). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Actoplus Met (Pioglitazone/Metformin).