Benadryl Itch Spray (Diphenhydramine Hcl/Zinc Acetate - non Rx) Customer Reviews

Benadryl Itch Spray

Rx Prescription Required    RxFormulation : Spray

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Diphenhydramine is commonly used to alleviate itching and discomfort resulting from minor burns, cuts, scrapes, sunburn, insect bites, and skin irritations. Diphenhydramine can also be effective in reducing itching associated with allergic reactions, such as those caused by exposure to poison ivy, poison oak, or poison sumac.

Diphenhydramine is classified as an antihistamine, it works by blocking the effects of histamine, a natural substance in the body that plays a role in allergic reactions. By inhibiting histamine, diphenhydramine helps relieve symptoms such as itching and pain caused by various skin conditions and irritations.

Uses and Dosage

Only use this medication on the skin as per your doctor’s instructions. If you’re self-administering, adhere to the guidelines provided in the product package. Seek guidance from your doctor or pharmacist for any queries. Shake certain products well before application.

Prior to use, cleanse the affected area with soap and water, gently patting it dry. Apply to the affected region as directed, typically no more than 3 to 4 times daily. Wash hands promptly unless the treated area includes the hands.

Do not apply on large body areas or exceed the recommended frequency. Faster improvement is not guaranteed, and the risk of side effects may rise.

Avoid contact with eyes, nose, ears, or mouth. If the medication comes into contact with these areas, wipe it off and rinse immediately with water.

Discontinue use and inform your doctor if your condition worsens, if symptoms persist beyond 7 days, or if they clear up and reoccur shortly. Seek immediate medical assistance if you suspect a serious medical issue.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • skin rash
  • sunburn
  • increased sensitivity to sunlamps and sunlight


  • Prior to using this product, inform your doctor or pharmacist about any allergies you have, whether it’s to diphenhydramine, any other ingredients listed on the product package, dimenhydrinate, or any other substances. Inactive ingredients in the product may trigger allergic reactions or other complications.
  • Before using this medication, disclose your medical history to your doctor or pharmacist, especially if you are self-treating and have a history of chickenpox or measles.
  • During pregnancy, use this medication only when absolutely necessary. Have a discussion with your doctor about the potential risks and benefits associated with its use.
  • This medication may pass into breast milk. Consult your doctor before breast-feeding.

Form and Strength

Benadryl Itch Spray is available in the following forms and strengths:

  • Benadryl Itch Spray spray:
    • 2 % / 0.1 %


How fast does Benadryl work for itching?

It usually takes Benadryl about 15 to 30 minutes to start working. The effects of Benadryl tend to last for 4 to 6 hours, but the medication can stick around in the body for much longer.

How often can I use Benadryl Itch Spray?

Spray on affected area not more than 3 to 4 times daily



Additional information

Generic name:

Diphenhydramine Hcl/Zinc Acetate – non Rx





Quantities Available:


Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Benadryl Itch Spray (Diphenhydramine Hcl/Zinc Acetate - non Rx). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Benadryl Itch Spray (Diphenhydramine Hcl/Zinc Acetate - non Rx).