Prescription Required 
Formulation : 
Description
Indications
Indinavir is employed in conjunction with other medications to address human immunodeficiency virus (HIV) infection.
Classified as a protease inhibitor, indinavir functions by reducing the quantity of HIV in the blood. While indinavir does not offer a cure for HIV, it may diminish the likelihood of developing acquired immunodeficiency syndrome (AIDS) and HIV-related conditions like severe infections or cancer.
Uses and Dosage
Indinavir is available in capsule form for oral administration. Typically, it is taken every 8 hours (three times a day).
Follow a consistent schedule by taking indinavir around the same times each day. Take indinavir precisely as directed—avoid taking more or less than prescribed or altering the frequency without consulting your doctor.
Consume indinavir on an empty stomach, either 1 hour before meals or 2 hours after meals, with water, skim or nonfat milk, juice, coffee, or tea. However, if indinavir causes stomach upset, it can be taken with a light meal, such as dry toast or cornflakes with skim or nonfat milk. Discuss with your doctor or pharmacist regarding suitable foods to be taken with indinavir.
Do not crush or chew the capsule, although it can be opened and mixed with fruit puree (such as banana).
Continue taking indinavir even if you feel well. Do not discontinue the medication without consulting your doctor.
In case you experience certain side effects, your doctor may need to interrupt your treatment. Ensure to communicate how you are feeling during your indinavir treatment.
Side Effects
Some side effects may occur that usually do not need medical attention:
- change in sense of taste
Inform your healthcare provider immediately if you experience any serious side effects:
- rash
- hives
- itching
- peeling or blistering skin
- back pain
- pain in the side of your body
- middle to lower stomach pain
- blood in urine
- muscle pain or weakness
- nausea
- excessive tiredness
- unusual bleeding or bruising
- loss of appetite
- pain in the upper right part of your stomach
- flu-like symptoms
- dark yellow or brown urine
- yellowing of the skin or eyes
- shortness of breath
- fast heartbeat
- confusion
Caution
- Prior to taking indinavir, inform your doctor or pharmacist if you are allergic to it or if you have any other allergies. Inactive ingredients in the product may lead to allergic reactions or other complications.
- Before initiating this medication, communicate your medical history to your doctor or pharmacist, particularly if you have a history of high blood fat levels, diabetes, hemophilia, kidney problems, heart problems, or liver problems.
- Inform your doctor if you are pregnant before using this medication, as treatment can reduce the risk of transmitting HIV infection to your baby. Discuss the potential risks and benefits with your doctor.
- It is not known whether this medication passes into breast milk. Given that breast milk may transmit HIV, consult your doctor before breastfeeding.
Form and Strength
Crixivan is available in the following forms and strengths:
- indinavir capsule:
- 400 mg
FAQ
How does Crixivan work?
Indinavir binds to the protease active site and inhibits the activity of the enzyme, lowering viral production.
Resources
- https://www.hiv.uw.edu/page/treatment/drugs/indinavir#:~:text=Microbiology%20Section-,Mechanism%20of%20Action%3A,the%20activity%20of%20the%20enzyme
- https://www.medbroadcast.com/drug/getdrug/crixivan#google_vignette
- https://www.webmd.com/drugs/2/drug-12337/crixivan-oral/details
- https://medlineplus.gov/druginfo/meds/a696028.html
- https://www.drugs.com/cdi/crixivan.html
