Janumet (sitagliptin/metformin hydrochloride) is an oral prescription drug indicated for type-2 diabetes patients. This medication is used to control high blood sugar levels, together with proper diet and regular exercise.
This oral tablet contains the combination of two potent antihyperglycemic agents, namely sitagliptin and metformin hydrochloride. Sitagliptin is a DPP-4 inhibitor that can slow down the inactivation of incretin hormones. If active incretin levels are prolonged, it could increase insulin release and decrease the levels of glucagon in the system in a glucose-dependent manner. Moreover, metformin hydrochloride is a biguanide that could improve glucose tolerance. It efficiently decreases the production of hepatic glucose and absorption of glucose in the intestine. It could also boost sensitivity to insulin by increasing peripheral glucose uptake and utilization.
Carefully read the prescription guide for Janumet before taking this medication. Follow the instructions given by your doctor and tell your doctor about any medical condition or medical history that may affect your treatment.
Janumet dosage depends on your condition, response to treatment, and if you are taking any other drugs. Take this oral antihyperglycemic regularly and precisely. Do not stop abruptly or change your dose without your doctor’s advice.
Take this medication orally with meals. Drink a lot of water while taking this medication unless contraindicated in your condition. Swallow the tablet and avoid chewing, cutting, or crushing it.
As Janumet may not entirely dissolve in your system, it is normal to see part of the tablet in your stool. Note that it doesn’t make the drug less effective.
Be sure to follow a diet plan and a regular exercise schedule. This medication is only a part of your program to control your blood sugar levels.
Some of the common side effects you may experience are:
-stomach upset or diarrhea
-metallic taste in the mouth
Some side effects usually resolve on their own. But, conversely, there are some severe side effects you should watch out for. Contact your doctor or any healthcare provider if you experience any signs of kidney problem (change in urine output), signs of heart failure (difficulty breathing, extreme fatigue, swelling of extremities), and signs of hypoglycemia (thirst, frequent urination, confusion).
Avoid taking Janumet if you have a known allergy to sitagliptin, metformin hydrochloride, or any active ingredients this medication may have. Signs of an allergic reaction include skin rash, itchiness, swelling, and difficulty breathing.
Talk to your doctor about your medical history or any medical condition you currently have. Janumet is contraindicated for patients who have a hepatic disease. Also, tell your doctor if you have a history of pancreatitis, gallstones, kidney disease, liver disease, or lung disease.
Drinking alcohol should be limited while on Janumet medication as alcohol may increase the risk of lactic acidosis and hypoglycemia.
In case of infection, injury, surgery, or any form of stress, controlling your blood sugar levels might be more challenging. Consult your physician as your dose might be increased during these circumstances.
If pregnant and breastfeeding, Janumet should only be used if highly needed. It is still unknown if this medication could affect the unborn child. However, studies show that this medication passes into the breastmilk in small amounts.
Frequently Asked Questions?
What are the available doses of Janumet?
It is available in Janumet 50/500 mg and Janumet 50/1000 mg. Follow the dose prescribed by your physician.
Janumet vs Janumet XR – What is the difference?
Both are prescription medications for type-2 diabetes. Janumet is usually taken twice a day, whereas Janumet XR (extended-release) is only taken once a day.
Is Janumet expensive?
You can check Janumet pricing at the top of this page. You may contact us for more information.
Can I cut Janumet in half?
It is recommended to swallow this tablet whole.
What if I miss a dose?
In case of missing a dose, take Janumet with food as soon as possible. If it is close to your next dose, skip the missed dose and go back to your regular schedule. Do not take two doses of Janumet simultaneously as this may lead to hypoglycemia.