Description
Indications
Finerenone is indicated for the management of chronic kidney disease in adult patients who have type 2 diabetes. Chronic kidney disease is a condition that results in kidney damage, which may progressively worsen and eventually lead to kidney failure. This medication is intended to mitigate the risk of deteriorating kidney function, hospitalization due to heart failure, as well as life-threatening heart and blood vessel diseases or a heart attack.
Finerenone is classified as a mineralocorticoid receptor (MR) antagonist and functions by impeding the action of specific steroids produced in the body that may be harmful to the heart and kidneys.
Uses and Dosage
Administer this medication orally as per your doctor’s instructions, either with or without food, typically once daily.
To mitigate the risk of side effects, your physician may advise commencing treatment with a low dose and gradually increasing the dosage. Comply with your doctor’s instructions.
In the event that swallowing the tablets whole is difficult, you can crush the tablet and mix it with soft foods (such as applesauce) or water. Consume the entire mixture immediately, without preparing a supply for future use.
The prescribed dosage is contingent on your medical condition and response to therapy.
In order to derive maximum benefit from this medication, use it consistently. To facilitate adherence, take it at the same time each day.
Do not exceed the prescribed dose or use this medication more frequently or for an extended duration than directed by your doctor. Doing so will not expedite improvement in your condition, but it will increase the likelihood of side effects.
Unless otherwise instructed by your doctor or pharmacist, avoid consuming grapefruit or grapefruit juice while using this medication. Grapefruit can heighten the possibility of adverse effects with this drug.
Side Effects
Some side effects may occur that usually do not need medical attention:
- confusion
- irregular heartbeat
- nausea or vomiting
- nervousness
- numbness or tingling in the hands, feet, or lips
- stomach pain
- trouble breathing
- weakness or heaviness of the legs
Inform your healthcare provider immediately if you experience any serious side effects:
- blurred vision
- decreased urine output
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast heartbeat
- headache
- increase thirst
- muscle pain or cramps
- seizures
- sweating
- swelling of the face, ankles, or hands
- unusual tiredness or weakness
Caution
Prior to initiating treatment with finerenone, notify your physician or pharmacist of any allergies you may have, including hypersensitivity to this drug, or other allergens. Inactive ingredients in the product can cause allergic reactions or other complications.
Before using this medication, inform your doctor or pharmacist of your medical history, particularly if you have a history of high levels of potassium in your blood (hyperkalemia), reduced adrenal gland function, or liver disease.
This medication can raise your potassium levels. If you are considering using potassium supplements or salt substitutes that contain potassium, consult your physician or pharmacist first.
This medication can induce dizziness. The use of alcohol or marijuana can exacerbate the dizziness. Refrain from driving, operating machinery, or engaging in activities that require alertness until you can do so safely.
During pregnancy, use this medication only if deemed necessary by your doctor. Discuss the potential risks and benefits with your physician.
It is unclear whether this medication passes into breast milk. Due to the possible hazards to the infant, breastfeeding should be avoided while taking this drug and for 24 hours following cessation of treatment. Consult your physician before breastfeeding.
Form and Strength
Kerendia is available in the following forms and strengths:
-
Kerendia film-coated tablet:
- 10mg
- 20mg
FAQ
How long does it take for Kerendia to start working?
Kerendia will begin working as soon as you take your first dose of medication.
What foods should you avoid when taking Kerendia?
You should avoid grapefruit and grapefruit juice during treatment with this medication.
Resources
- https://www.medicalnewstoday.com/articles/drugs-kerendia#how-it-works
- https://www.drugs.com/food-interactions/finerenone,kerendia.html#:~:text=Finerenone%20may%20be%20taken%20with,levels%20and%20effects%20of%20finerenone
- https://medlineplus.gov/druginfo/meds/a621038.html
- https://www.webmd.com/drugs/2/drug-181913/kerendia-oral/details
- https://www.mayoclinic.org/drugs-supplements/finerenone-oral-route/before-using/drg-20518736?p=1
- https://www.drugs.com/kerendia.html