Prescription Required 
Formulation : 
Description
Indications
Linaclotide is indicated for the management of specific gastrointestinal disorders, including Irritable Bowel Syndrome Constipation and Chronic Idiopathic Constipation. It functions by augmenting fluid levels within the intestines and facilitating the transit of waste products within the body. As a result, linaclotide may enhance stool consistency and alleviate symptoms such as abdominal bloating, discomfort, straining, and a sense of incomplete evacuation.
Uses and Dosage
Linaclotide is administered orally in the form of a capsule and is typically taken once daily, on an empty stomach, at least thirty minutes prior to the first meal of the day.
Adhere to a consistent dosing schedule and to follow the instructions provided on the prescription label closely. In case of any confusion, seek clarification from your healthcare provider or pharmacist. Take Linaclotide exactly as directed by your doctor and to not alter the dose or frequency of administration without prior medical consultation.
The capsules should be swallowed whole and should not be broken, chewed, or crushed.
Linaclotide effectively manages the symptoms of Irritable Bowel Syndrome Constipation (IBS-C) and Chronic Idiopathic Constipation (CIC); it does not cure these conditions. Improvements in constipation symptoms may occur within one week of starting treatment, with longer duration for improvement in abdominal pain. Continue taking linaclotide as prescribed, even if you are feeling well.
Side Effects
Some side effects may occur that usually do not need medical attention:
- body aches or pain
- chills
- ear congestion
- excess air or gas in the stomach or intestines
- fever
- full or bloated feeling
- headache
- loss of voice
- passing gas
- sneezing
- sore throat
- stuffy or runny nose
Inform your healthcare provider immediately if you experience any serious side effects:
- severe diarrhea
- stomach pain
- heartburn
- loss of appetite
- nausea
- vomiting
- weakness
Caution
Inform your healthcare provider or pharmacist prior to starting treatment with linaclotide if you have a history of hypersensitivity to the drug or any other allergies. The product may contain inactive ingredients that may elicit allergic reactions or other adverse effects.
Your medical history, particularly any history of gastrointestinal obstruction, should be disclosed to your healthcare provider or pharmacist prior to starting treatment with linaclotide.
During pregnancy, the use of linaclotide should only be considered when the potential benefits outweigh the potential risks.
Form and Strength
Linzess is available in the following forms and strengths:
-
Linzess capsule:
- 72 mcg
- 145 mcg
- 290 mcg
FAQ
How long does it take for Linzess to work?
Constipation relief is typically felt in about 1 week. IBS-C patients may begin to experience relief of belly pain and overall abdominal symptoms* (pain, discomfort, and bloating) in about 1 week, with symptoms typically improving over 12 weeks.
What type of laxative is linaclotide?
Linaclotide is not a laxative.
Resources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638410/
- https://www.mayoclinic.org/drugs-supplements/linaclotide-oral-route/side-effects/drg-20075770?p=1
- https://www.drugs.com/linzess.html#warnings
- https://www.webmd.com/drugs/2/drug-162895/linzess-oral/details
- https://medlineplus.gov/druginfo/meds/a613007.html
