Motegrity (Prucalopride Succinate)

Description

Indications

Prucalopride is indicated for the treatment of chronic constipation, particularly in cases where prior interventions, such as the use of laxatives, have not yielded the desired outcome. Prucalopride is in a class of medications called serotonin receptor agonists and it exerts its therapeutic effect by improving how well your stomach and intestines move food through the bowels during digestion.

Uses and Dosage

The administration of this medication should be in accordance with your physician’s instructions, with or without food, typically once daily.

The dosage is determined based on your age, medical history, and therapeutic response, with a standard dose of 2 milligrams per day.

For optimal results, take this medication regularly and at the same time each day. In the event that constipation persists for 3 to 4 days despite treatment, inform your healthcare provider. Your physician may recommend the temporary use of additional medication, such as a stimulant laxative, in conjunction with prucalopride to achieve rapid relief from constipation. Adhere to your physician’s instructions for the use of any supplementary medication.

Side Effects

Some side effects may occur that usually do not need medical attention:

• headache
• stomach pain
• nausea
• diarrhea
• dizziness

Inform your healthcare provider immediately if you experience any serious side effects:

• difficulty breathing or shortness of breath
• rash
• itching
• hives
• swelling of face, lips, tongue, or throat

Caution

Prior to initiating treatment with prucalopride, inform your physician or pharmacist about any allergies you may have, including to this medication or any other substances. This product may contain inactive ingredients, such as lactose, that could trigger allergic reactions or other complications.

Apprise your physician or pharmacist of your medical history, especially if you have a history of diabetes, heart problems, kidney issues, liver disease, mental or mood disorders, or other stomach/abdominal disorders (such as intestinal perforation/obstruction, ileus, Crohn’s disease, or ulcerative colitis) prior to commencing therapy with this medication.

This medication may induce dizziness. Consumption of alcohol or marijuana may exacerbate this side effect. Avoid activities that require alertness, such as driving or operating machinery, until you can do so safely.

During pregnancy, this medication should only be used if the potential benefits outweigh the risks. Discuss the potential benefits and risks with your physician.

This medication is excreted into breast milk. Prior to breastfeeding, consult with your physician.

Form and Strength

Motegrity is available in the following forms and strengths:

• Motegrity film-coated tablet:
  • 1mg
  • 2mg
• prucalopride tablet:
  • 2mg

FAQ

How many days does it take for Motegrity to work?

While your results may vary, people who started Motegrity in clinical studies had their first complete spontaneous bowel movement within 1.4 to 4.7 days.

Is weight loss a side effect of Motegrity?

No, Motegrity isn’t expected to cause weight loss.

Resources

1. https://www.motegrity.com/what-to-expect/frequently-asked-questions#:~:text=How%20quickly%20does%20Motegrity%20work,and%20what%20to%20expect%20here
2. https://www.healthgrades.com/drugs/motegrity#:~:text=Will%20Motegrity%20cause%20weight%20loss,t%20have%20a%20known%20cause
3. https://www.mayoclinic.org/drugs-supplements/prucalopride-oral-route/side-effects/drg-20452343?p=1
4. https://www.webmd.com/drugs/2/drug-176850/motegrity-oral/details
5. https://medlineplus.gov/druginfo/meds/a619011.html
6. https://www.drugs.com/motegrity.html