Combigan (Brimonidine Tartrate/Timolol Maleate) Customer Reviews


Rx Prescription Required    RxFormulation : Eye Drops

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Generic alternative for Combigan

Brimonidine Tartrate/Timolol Maleate

Rx Prescription Required    RxFormulation : Eye Drops

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This combination medication is used for the treatment of elevated eye pressure caused by glaucoma (specifically, open-angle type) or other eye diseases, such as ocular hypertension. This medication comprises two active ingredients, brimonidine and timolol, which are co-administered when a single agent is insufficient in controlling intraocular pressure.

Brimonidine works by allowing better fluid drainage. It is classified as an alpha agonist. Timolol is thought to work by decreasing the amount of fluid formed in the eye and is categorized as a beta blocker.

Uses and Dosage

The ophthalmic formulation of brimonidine is a liquid solution intended for administration by instillation into the eyes. Typically, the affected eye(s) are treated three times daily, with efforts made to ensure an approximately 8-hour interval between each of the three daily doses.

Follow the instructions provided on the prescription label meticulously, and in case of any confusion, consult with the prescribing doctor or pharmacist. The use of brimonidine eye drops should adhere strictly to the prescribed regimen, with no deviations in dosage frequency or quantity.

While brimonidine eye drops can manage the underlying condition, they do not effect a cure. As such, continue using the medication even if symptoms appear to subside. The cessation of brimonidine eye drops should only be done under the guidance of a medical professional.

To administer the eye drops, the following steps should be followed:

  1. Thoroughly wash hands with soap and water.
  2. Do not allow the dropper tip to touch the eye or any other surface, and ensure that it is kept clean.
  3. Tilt the head back and pull down the lower lid of the eye using the index finger to form a pocket.
  4. Hold the dropper as close to the eye as possible without making contact, and brace the remaining fingers against the face.
  5. Squeeze the dropper gently to instill a single drop in the pocket created by the lower eyelid while looking upwards.
  6. Remove the index finger from the lower eyelid and keep the eye closed for 2-3 minutes while tilting the head down.
  7. Apply gentle pressure to the tear duct using a finger.
  8. Use a tissue to wipe off any excess liquid from the face.
  9. Wash hands to remove any residual medication.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • itchy, irritated, red, stinging, or burning eyes
  • dry eyes
  • watery or runny eyes
  • red or swollen eyelids
  • sensitivity to light
  • blurred vision
  • headache
  • drowsiness
  • difficulty falling asleep or staying asleep
  • dry mouth
  • runny nose and other cold symptoms
  • cough
  • sore throat
  • flu-like symptoms
  • pain or pressure in the face
  • heartburn

Inform your healthcare provider immediately if you experience any serious side effects:

  • rash
  • difficulty breathing
  • seeing specks or flashes of light
  • blind spots
  • fainting
  • dizziness
  • nausea


Prior to using this product, inform your doctor or pharmacist of any known allergies to brimonidine or timolol, or to apraclonidine, as well as any other allergies. Inactive ingredients present in the product may also elicit allergic reactions or other complications.

Before commencing use of this medication, disclose your medical history to your doctor or pharmacist, particularly if you have a history of lung disease, certain types of irregular heartbeats, heart disease, kidney disease, liver disease, blood vessel disease, blood circulation disorders, dizziness after standing, diabetes, depression, overactive thyroid (hyperthyroidism), muscle weakness disorders (such as myasthenia gravis), or severe allergies.

In the event of an eye infection or injury, or following eye surgery, consult with your doctor regarding the continued use of your current bottle of medication. You may be instructed to start using a new bottle.

For individuals with diabetes, this product may prevent the fast or pounding heartbeat typically experienced during hypoglycemia. Other symptoms of low blood sugar, such as dizziness and sweating, are not affected by this medication.

This medication may cause temporary vision blurring, dizziness, or drowsiness. The consumption of alcohol or marijuanamay intensify these effects. Refrain from driving, operating machinery, or engaging in activities requiring clear vision or alertness until you can do so safely.

This medication should only be used during pregnancy when necessary, after discussion with your doctor regarding the risks and benefits.

While this medication can pass into breast milk, it is unlikely to cause harm to nursing infants. Consult with your doctor before breastfeeding.

Form and Strength

Combigan is available in the following forms and strengths:

  • Combigan eye drops:

    • 5ml
    • 10ml
  • brimonidine and timolol ophthalmic eye drops:

    • 5ml


How long does Combigan take to work?

Combigan starts to work pretty quickly, within 1 to 2 hours.

Does Combigan cause tiredness?

Drowsiness is a possible side effect from Combigan eye drops.



Additional information

Generic name:

Brimonidine Tartrate/Timolol Maleate


Eye Drops



Quantities Available:

5mL, 10mL, 15mL

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Combigan (Brimonidine Tartrate/Timolol Maleate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Combigan (Brimonidine Tartrate/Timolol Maleate).