Compazine (Prochlorperazine) Customer Reviews


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Generic alternative for Compazine


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Prochlorperazine is a medication used for managing severe nausea and vomiting. It is available in both tablet and suppository form. Apart from its antiemetic properties, prochlorperazine tablets are also used for treating symptoms of schizophrenia, such as disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions. In addition, these tablets are prescribed for short-term treatment of anxiety that is resistant to other medications.

Prochlorperazine should not be given to children under 2 years of age or those weighing less than 20 pounds (about 9 kilograms). Prochlorperazine belongs to a class of medications known as conventional antipsychotics, which reduce abnormal excitement in the brain.

Uses and Dosage

Prochlorperazine is available as an oral tablet or rectal suppository. The tablet is typically taken by adults three to four times a day and by children once to three times a day. The suppository is usually inserted twice daily.

Take Prochlorperazine at the same time(s) every day and to follow the instructions on your prescription label carefully. Do not use prochlorperazine more or less than prescribed or more frequently than directed.

Your doctor may initiate prochlorperazine at a low dose and increase it gradually, but not more than once every 2-3 days.

If you’re using prochlorperazine to treat schizophrenia, it can help manage your symptoms but not cure the condition. Even if you feel better, continue taking prochlorperazine as prescribed by your doctor. Do not stop taking prochlorperazine without consulting your doctor. Abruptly discontinuing the medication may cause withdrawal symptoms, such as nausea, vomiting, dizziness, and tremors.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • dizziness, feeling unsteady, or having trouble keeping your balance
  • blurred vision
  • dry mouth
  • stuffed nose
  • headache
  • nausea
  • constipation
  • difficulty urinating
  • widening or narrowing of the pupils (black circles in the center of the eyes)
  • increased appetite
  • weight gain
  • agitation
  • jitteriness
  • difficulty falling asleep or staying asleep
  • blank facial expression
  • drooling
  • uncontrollable shaking of a part of the body
  • shuffling walk
  • breast enlargement
  • breast milk production
  • missed menstrual periods
  • decreased sexual ability in men

Inform your healthcare provider immediately if you experience any serious side effects:

  • fever
  • muscle stiffness
  • falling
  • confusion
  • fast or irregular heartbeat
  • sweating
  • yellowing of the skin or eyes
  • flu-like symptoms
  • sore throat, chills, and other signs of infection
  • neck cramps
  • tongue that sticks out of the mouth
  • tightness in the throat
  • difficulty breathing or swallowing
  • fine, worm-like tongue movements
  • uncontrollable, rhythmic face, mouth, or jaw movements
  • seizures
  • rash
  • hives
  • itching
  • swelling of the eyes, face, mouth, lips, tongue, throat, arms, hands, feet, ankles, or lower legs
  • vision loss, especially at night
  • seeing everything with a brown tint
  • coma (loss of consciousness for a period of time)
  • erection that lasts for hours


Before using prochlorperazine, inform your doctor or pharmacist about any allergies you may have, particularly if you are allergic to other phenothiazines like chlorpromazine, or if you have any other allergies. This medication may contain inactive ingredients that can lead to allergic reactions or other issues.

Prior to taking this medication, discuss your medical history with your doctor or pharmacist, especially if you have breathing difficulties such as asthma or chronic obstructive pulmonary disease (COPD), blood or immune system disorders such as bone marrow depression, high pressure in the eye (glaucoma), heart disease like irregular heartbeat, liver disease, kidney disease, certain brain disorders such as Reye’s syndrome or seizures, stomach or intestine problems like blockage, difficulty urinating due to an enlarged prostate, or pheochromocytoma.

This medication can cause drowsiness, dizziness, or blurred vision, and alcohol or marijuana can increase these effects. Do not drive, operate machinery, or engage in any activity that requires alertness or clear vision until you can do so safely.

This medication can increase your sensitivity to the sun. Limit your time spent in the sun, avoid tanning booths and sunlamps, use sunscreen, and wear protective clothing when outside. If you experience sunburn or skin blisters or redness, seek medical attention immediately.

Using this medication can cause you to sweat less, which may increase your risk of heat stroke. Avoid activities that may cause you to overheat, such as hard work or exercise in hot weather or using hot tubs. When it’s hot outside, drink plenty of fluids and wear light clothing. If you overheat, find a cool place to rest and seek medical attention immediately if you experience fever, mental or mood changes, headache, or dizziness.

Children may be more susceptible to the side effects of this medication, particularly uncontrolled movements, and may be at greater risk when they are sick, such as during a viral infection or dehydration.

Older adults may also be more susceptible to the side effects of this medication, particularly low blood pressure, constipation, urinary problems, and nerve/muscle problems.

During pregnancy, this medication should only be used when absolutely necessary, and it’s important to discuss the risks and benefits with your doctor. Babies born to mothers who have used this medication during the last three months of pregnancy may rarely develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn at any time during their first month, seek medical attention immediately.

It’s unknown whether prochlorperazine passes into breast milk, but similar drugs have been known to do so. Consult your doctor before breastfeeding.

Form and Strength

Compazine is available in the following forms and strengths:

  • Compazine tablet:

    • 5mg
  • prochlorperazine tablet:

    • 5mg
    • 10mg


Is Compazine an antipsychotic?

Compazine is a piperazine phenothiazine and first-generation antipsychotic drug.

Does Compazine work immediately?

Compazine starts to work in around 30 to 60 minutes.



Additional information

Generic name:





5mg, 10mg

Quantities Available:

84, 100

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Compazine (Prochlorperazine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Compazine (Prochlorperazine).