Prescription Required 
Formulation : 
Description
Indications
Valproic acid is prescribed either alone or in combination with other medications to address specific types of seizures.
It is also employed to manage episodes of mania in individuals with bipolar disorder. Valproic acid can additionally be utilized for the prevention of migraine headaches, but it is not intended to relieve headaches that have already started.
This medication falls into the category of anticonvulsants, and it functions by augmenting the levels of a particular natural substance in the brain.
Uses and Dosage
Valproic acid is available in various forms, including capsules, extended-release tablets, delayed-release tablets, sprinkle capsules, and syrup, all taken orally. The syrup, capsules, delayed-release tablets, and sprinkle capsules are typically taken two or more times a day, while the extended-release tablets are usually taken once daily. To prevent stomach upset, it is advisable to take valproic acid with food, at the same time(s) every day.
Take valproic acid exactly as prescribed—avoid taking more or less or altering the frequency without your doctor’s approval.
Swallow regular capsules, delayed-release capsules, and extended-release tablets whole; do not split, chew, or crush them.
For sprinkle capsules, you can either swallow them whole or open them to sprinkle the beads on a teaspoonful of soft food, such as applesauce or pudding. Consume the mixture promptly without chewing the beads, and do not store any unused mixtures of food and medication.
Do not mix the syrup with any carbonated drink.
Divalproex sodium, valproate sodium, and valproic acid products are absorbed differently by the body and cannot be substituted for one another. If you need to switch products, your doctor may need to adjust your dose.
Your doctor may initiate treatment with a low dose and gradually increase it. Valproic acid may help control your condition but will not cure it. Continue taking it even if you feel well. Do not stop without consulting your doctor, especially if you experience side effects or discover you are pregnant. Abruptly stopping valproic acid may lead to severe, prolonged, and potentially life-threatening seizures. Your doctor will likely taper your dose gradually.
Side Effects
Some side effects may occur that usually do not need medical attention:
- drowsiness
- dizziness
- headache
- diarrhea
- constipation
- changes in appetite
- weight changes
- back pain
- agitation
- mood swings
- abnormal thinking
- uncontrollable shaking of a part of the body
- problems with walking or coordination
- uncontrollable movements of the eyes
- blurred or double vision
- ringing in the ears
- hair loss
Inform your healthcare provider immediately if you experience any serious side effects:
- unusual bruising or bleeding
- tiny purple or red spots on the skin
- fever
- rash
- bruising
- hives
- difficulty breathing or swallowing
- swollen glands
- swelling of face, eyes, lips, tongue, or throat
- peeling or blistering skin
- confusion
- tiredness
- vomiting
- drop in body temperature
- weakness or swelling in the joints
Caution
- Prior to initiating valproic acid treatment, inform your doctor or pharmacist about any known allergies you may have, including allergies to valproic acid, divalproex, valproate sodium, or any other substances. This medication may contain inactive ingredients, such as peanut oil, that could trigger allergic reactions or other complications.
- Before using this medication, disclose your medical history to your doctor or pharmacist, particularly if you have a history of liver disease, pancreatitis, certain metabolic disorders, alcohol abuse, bleeding disorders, brain disease (dementia), kidney disease, dehydration, or poor nutrition.
- To minimize the risk of cuts, bruises, or injuries, exercise caution when handling sharp objects like razors and nail cutters, and avoid participating in activities that involve contact sports.
- This medication may cause dizziness, drowsiness, or blurred vision. Consumption of alcohol or marijuana can intensify these effects. Refrain from driving, operating machinery, or engaging in tasks that require alertness or clear vision until you can safely do so.
- Children under the age of 6 may face a higher risk of liver problems and pancreatitis.
- Older adults may be more susceptible to the side effects of this medication, particularly drowsiness, dizziness, unsteadiness, or tremors. These effects can increase the risk of falls.
- Inform your doctor if you are pregnant or planning to become pregnant. You should not become pregnant while using valproic acid, as it may harm an unborn baby. If you become pregnant, promptly consult your doctor regarding the risks and benefits associated with this medication.
- This medication passes into breast milk. Although no harm to nursing infants has been reported, consult your doctor before breastfeeding.
Form and Strength
Depakene Oral Solution is available in the following forms and strengths:
- Depakene Oral Solution syrup:
- 250 mg / 5 mL
- valproic acid syrup:
- 250 mg / 5 mL
FAQ
Does Depakene help with anxiety?
Depakene is only FDA-approved to treat certain types of seizures. There was one small study that showed that it might help with social anxiety disorder, but more research is needed.
How quickly does Depakene work?
While it only takes a few hours for your body to fully absorb Depakene, it can take a few weeks before you start to notice a difference in your symptoms.
Resources
- https://www.goodrx.com/valproic-acid/what-is
- https://www.mayoclinic.org/drugs-supplements/valproic-acid-oral-route/description/drg-20072931
- https://www.webmd.com/drugs/2/drug-9702-9019/depakene-oral/valproate-sodium-syrup-oral/details
- https://medlineplus.gov/druginfo/meds/a682412.html
- https://www.drugs.com/cons/depakene.html
