Prescription Required 
Formulation : 
Description
Indications
This medication is an extended-release formulation of flupentixol, utilized in the treatment of mental and mood disorders such as schizophrenia and psychosis. Flupentixol decanoate is typically prescribed for patients who have previously been administered regular doses of flupentixol orally and may benefit from less frequent dosing for long-term maintenance treatment. Flupentixol aids in improving cognitive clarity, reducing hallucinations and negative thoughts, and enhancing daily functioning.
Belonging to the thioxanthenes class of medications, flupentixol is also categorized as a neuroleptic. Its mechanism of action involves influencing the balance of natural substances, known as neurotransmitters, in the brain.
Uses and Dosage
This medication is administered via injection into a muscle by a healthcare professional, following your doctor’s instructions, typically every 2 to 3 weeks. It should not be injected into a vein.
The dosage is determined based on your medical condition and response to treatment. Your doctor will adjust your dose to find the optimal amount for you. Initially, your first injection may be at a lower dose than your regular dose, with a possible second dose given 4 to 10 days later. Your doctor may also advise taking the oral form of this medication until the injected form takes effect.
Consistent use of this medication is crucial to maximize its benefits. It may be helpful to mark your calendar to remember when to receive your next dose. Ensure you keep all your medical appointments.
Do not discontinue using this medication without consulting your doctor, as stopping suddenly could worsen your condition. Your doctor may need to gradually decrease your dose.
Inform your doctor if your symptoms do not improve or if they worsen.
Side Effects
Some side effects may occur that usually do not need medical attention:
- changes in menstrual periods
- constipation
- decreased interest in sexual activity
- decreased sexual ability
- dizziness
- dry mouth
- fatigue
- increased production of saliva
- increased sensitivity of the skin to sunlight
- increased sweating
- swelling of breasts (in men and women)
- unusual secretion of milk
- weight changes
Inform your healthcare provider immediately if you experience any serious side effects:
- blurred vision or other eye problems
- circular eye movement
- decreased blood pressure (fainting, dizziness, lightheadedness)
- difficult urination
- fast, pounding, or irregular heartbeat
- mask-like face
- muscle spasms, especially of the neck and back
- new or worsening constipation
- severe restlessness or need to keep moving
- shuffling walk
- yellowing of skin or whites of eyes
- abdominal pain
- dark urine
- light-coloured stools
- skin rash
- stiffness of arms and legs
- trembling and shaking of fingers and hands
- uncontrolled body movements
- long-lasting (more than 4 hours) and painful erection
- seizures
Caution
- Before using flupentixol, it’s important to inform your doctor or pharmacist about any allergies you have, including allergies to other thioxanthenes like thiothixene or zuclopenthixol, or any other substances. This medication may contain inactive ingredients that could trigger allergic reactions or other issues.
- Disclose your medical history to your doctor or pharmacist before using this medication, especially if you have a history of blood disorders, high or low blood pressure, brain disorders, circulation issues, breast cancer, glaucoma, slowed gut movement, kidney problems, liver problems, Parkinson’s disease, pheochromocytoma, seizures, difficulty urinating, or substance dependency.
- This medication may cause dizziness or drowsiness. Alcohol or marijuana can exacerbate these effects. Avoid driving, operating machinery, or engaging in tasks requiring alertness until you can do so safely.
- This medication may increase sensitivity to sunlight. Limit sun exposure, avoid tanning booths and sunlamps, and use sunscreen and protective clothing when outdoors. Notify your doctor if you experience sunburn or skin blisters/redness.
- Flupentixol may reduce sweating, increasing the risk of heat stroke. Avoid overheating, especially in hot weather or when exercising vigorously. Stay hydrated and dress appropriately for the weather. Seek medical help if you experience persistent fever, changes in mental state, headache, or dizziness due to overheating.
- Avoid contact with certain insecticides (organophosphates) while using this medication.
- Flupentixol may prolong the QT interval, which can lead to serious irregular heartbeats. Inform your doctor about all medications you’re taking and any medical conditions you have, as they may increase the risk of QT prolongation.
- Elderly individuals may be more sensitive to the side effects of this medication, such as drowsiness, dizziness, muscle stiffness, uncontrolled movements, and QT prolongation. These effects can increase the risk of falls.
- During pregnancy, use this medication only if clearly necessary, as it may rarely cause symptoms in newborns if used during the last 3 months of pregnancy. If you notice any symptoms in your newborn, especially during the first month, inform your doctor promptly.
- Untreated mental/mood disorders can be serious, so do not stop taking this medication unless directed by your doctor. If you’re planning pregnancy, become pregnant, or suspect you’re pregnant, discuss the risks and benefits of using this medication with your doctor.
- Flupentixol passes into breast milk and may harm nursing infants. Breastfeeding while using this medication is not recommended.
Form and Strength
Fluanxol Depot is available in the following forms and strengths:
- Fluanxol Depot vial:
- 20 mg/mL
FAQ
How long does Fluanxol Depot take to work?
It may take several weeks to feel the full benefit of this medication.
Does Fluanxol Depot cause weight gain?
Weight is a potential side effect of taking Fluanxol Depot, especially with prolonged use.
Resources
- https://www.rxhealthmed.ca/medication_search/fluanxol-depot/
- https://www.news-medical.net/drugs/Fluanxol.aspx#:~:text=Fluanxol%20belongs%20to%20a%20group,has%20been%20prescribed%20for%20you
- https://www.medbroadcast.com/drug/getdrug/fluanxol-depot#adverseeffects
- https://www.healthlinkbc.ca/medications/flupentixol-decanoate-injection
