Frontline Plus for Small Dogs (Fipronil/methoprene) Customer Reviews

Frontline Plus for Small Dogs

Rx Prescription Required    RxFormulation : Pipettes

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Generic alternative for Frontline Plus for Small Dogs


Rx Prescription Required    RxFormulation : Pipettes

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(up to 22 lbs or 10kg)
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The combination of fipronil and methoprene is employed for managing and addressing all phases of flea infestations and tick infestations in both dogs and cats. Fipronil serves as a phenylpyrazole antiparasitic agent, while methoprene acts as an insect growth regulator. Together, fipronil and methoprene exhibit efficacy in eliminating both adult and larval fleas, as well as flea eggs. The medication is also effective against all life stages of ticks. The mechanism of action involves interference with the central nervous system of insects, leading to their demise.

Uses and Dosage

Fipronil and methoprene are administered once a month, ideally as close to every 30 days as possible between doses.

Adhere to the guidelines provided on the drug label specific to the species or follow the instructions given by your veterinarian.

Apply these topical products to the skin after parting the fur. Administer the entire contents of the product applicator to a single location on the skin—between the shoulder blades in dogs and at the base of the neck in cats.

Wait for 24 hours after applying fipronil and methoprene before bathing your pet. If you plan to bathe your pet before application, ensure your pet is fully dried before applying the medication.

Be absolutely sure that your pet does not ingest this medication.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • temporary irritation at the site of application

Inform your veterinarian immediately if your pet experiences any serious side effects:

  • tremors
  • lack of coordination
  • seizures
  • lethargy
  • drooling
  • vomiting
  • loss of appetite


  • Avoid using fipronil and methoprene in animals with a known hypersensitivity or allergy to the drug.
  • As a topical agent, temporary irritation at the application site is possible.
  • This product is not advisable for use in debilitated or geriatric animals.
  • It is not recommended for use in puppies or kittens less than 8 weeks of age.
  • Spotted areas may appear wet or oily for up to 24 hours after application.
  • Overdose is rare, and no adverse effects have been reported, even at doses up to 5 times the standard dose.

Form and Strength

Frontline Plus for Small Dogs is available in the following forms and strengths:

  • fipronil and methoprene pipettes:
    • for dogs up to 10 kg


Why am I seeing more fleas on my dog or in my home after applying Frontline Plus For Dogs?

On the dog, the fleas that come into contact with Frontline Plus rise to the top of the haircoat as they die. In terms of the home, those fleas were likely eggs before you started using the medication.

Is Frontline Plus safe for puppies?

Frontline Plus for Dogs is safe for use on dogs 8 weeks and older.



Additional information

Generic name:





(up to 22 lbs or 10kg)

Quantities Available:


Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Frontline Plus for Small Dogs (Fipronil/methoprene). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Frontline Plus for Small Dogs (Fipronil/methoprene).