Glucotrol XL (Glipizide XL) Customer Reviews

Glucotrol XL

Rx Prescription Required    RxFormulation : Extended Release Tablet

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Generic alternative for Glucotrol XL

Glipizide XL

Rx Prescription Required    RxFormulation : ER Tablet

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Glipizide is prescribed in conjunction with a well-balanced diet and regular exercise regime to manage elevated blood sugar levels in individuals with type 2 diabetes. By effectively controlling high blood sugar, glipizide aids in the prevention of kidney damage, vision impairment, nerve complications, amputation risks, and sexual function issues. Maintaining proper diabetes control can reduce the likelihood of experiencing heart attacks or strokes. As a member of the sulfonylureas drug class, glipizide operates by stimulating the release of your body’s natural insulin, thus lowering blood sugar levels.

Uses and Dosage

Glipizide is available in tablet and extended-release (long-acting) tablet forms, which are taken orally. The regular tablet is typically consumed one or more times a day, about 30 minutes before breakfast or meals. The extended-release tablet is taken once a day during breakfast.

For consistent usage, take glipizide at the same time(s) daily. Take glipizide exactly as prescribed, avoiding any deviations in dosage, either taking more or less or increasing the frequency beyond what your doctor has advised.

Initially, your doctor will likely initiate treatment with a low dose of glipizide, and if necessary, they may gradually adjust the dosage over time. Communicate with your doctor about how you feel and any variations in your blood sugar test results during the course of treatment.

Sometimes, glipizide’s effectiveness in controlling blood sugar may diminish over time, and in such cases, your doctor may modify the dosage to optimize the medication’s benefits for you.

When taking the extended-release tablets, remember to swallow them whole and not to chew, divide, or crush them.

Glipizide assists in managing blood sugar levels, but it does not cure diabetes. Continue taking Glipizide even if you feel well. Never discontinue its usage without consulting your doctor.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • diarrhea
  • gas
  • feeling jittery
  • dizziness
  • uncontrollable shaking of a part of the body
  • red or itchy skin
  • rash
  • hives
  • blisters

Inform your healthcare provider immediately if you experience any serious side effects:

  • yellowing of the skin or eyes
  • light-colored stools
  • dark urine
  • pain in the upper right part of the stomach
  • unusual bruising or bleeding
  • fever
  • sore throat


Before starting glipizide, inform your doctor or pharmacist about any allergies you may have, as the product may contain inactive ingredients that could trigger allergic reactions or other issues.

Prior to using this medication, share your medical history with your doctor or pharmacist, especially if you have a history of liver disease, kidney disease, thyroid disease, certain hormonal conditions, or electrolyte imbalances (hyponatremia).

Be aware that extremely low or high blood sugar levels may cause blurred vision, dizziness, or drowsiness. In such cases, refrain from driving, using machinery, or engaging in activities that require alertness or clear vision until you are confident in your ability to do so safely.

While taking this medication, limit alcohol consumption, as it can increase the risk of low blood sugar. Alcohol may rarely interact with glipizide, leading to a serious reaction known as a disulfiram-like reaction, which may manifest as facial flushing, nausea, vomiting, dizziness, or stomach pain.

Stressful conditions, such as fever, infection, injury, or surgery, can make it harder to control your blood sugar. If your body experiences stress, contact your doctor, as it may necessitate changes in your treatment plan, medications, or blood sugar testing.

This medication may heighten your sensitivity to sunlight. Minimize your time spent in the sun and avoid tanning booths and sunlamps. When outdoors, use sunscreen and wear protective clothing. If you get sunburned or notice skin blisters/redness, inform your doctor promptly.

Older adults may be more susceptible to the side effects of this drug, particularly low blood sugar.

During pregnancy, use this medication only if clearly needed, as pregnancy can cause or exacerbate diabetes. Work out a blood sugar management plan with your doctor while pregnant. Your doctor may substitute insulin for this drug during pregnancy. If glipizide is used, it may be switched to insulin at least 2 weeks before the expected delivery date due to the risk of low blood sugar in your newborn. Discuss the risks and benefits with your doctor.

It is uncertain if this medication passes into breast milk, but similar drugs have been found to do so. Consult your doctor before breastfeeding.

Form and Strength

Glucotrol XL is available in the following forms and strengths:

  • Glucotrol XL extended-release tablet:

    • 2.5mg
    • 10mg
  • glipizide XL extended-release tablet:

    • 2.5mg
    • 10mg


Does Glucotrol XL cause weight gain?

Glucotrol belongs to a class of drugs called sulfonylureas. And weight gain has been reported with other drugs in this class.

Sulfonylureas may cause weight gain because they stimulate the release of insulin in your body.

How long does it take Glucotrol XL to work?

Glucotrol helps with the release of insulin that occurs after a meal. These effects occur within 30 minutes of an oral dose, even though it takes one to three hours for peak plasma concentrations to occur.



Additional information

Generic name:

Glipizide XL, Glipizide Xl


ER Tablet, Extended Release Tablet, Tablet


2.5mg, 10mg

Quantities Available:

30, 90, 100

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Glucotrol XL (Glipizide XL). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Glucotrol XL (Glipizide XL).