This medication combination is prescribed to manage high blood sugar levels in patients with type 2 diabetes. Along with a suitable diet and exercise program, it may be used in conjunction with other medications.
Sitagliptin functions by boosting levels of natural substances known as incretins, which aid in regulating blood sugar by stimulating insulin release, particularly after a meal. Metformin helps to restore your body’s natural insulin response and reduces the amount of sugar produced by your liver, as well as absorbed by your stomach/intestines. Properly controlling high blood sugar can help prevent complications such as kidney damage, blindness, nerve problems, loss of limbs, and sexual function issues.
Uses and Dosage
Follow your doctor’s instructions and take this medication orally, typically twice daily with meals. Unless otherwise advised by your doctor, drink plenty of fluids while taking the medication.
Do not break or cut the tablet before ingestion. Inform your doctor if you experience difficulty swallowing the tablet whole.
Your dose of the medication will be determined based on your medical condition, response to treatment, and other drugs you are taking. To minimize the risk of side effects like an upset stomach, your doctor may instruct you to begin with a low dose and gradually increase it. Follow your doctor’s instructions carefully.
Consistent use of this medication is essential for maximum benefit. Use it at the same times every day. If you are taking another diabetes medication like pioglitazone, closely adhere to your doctor’s advice on stopping/continuing the old medication and starting this one. Abide by your doctor’s recommendations regarding the medication treatment plan, meal plan, and exercise program.
Regularly check your blood sugar levels as instructed by your doctor. Record the readings and share them with your doctor. Inform your doctor if your blood sugar measurements are too high or too low, as your dosage or treatment may need adjustment.
Some side effects may occur that usually do not need medical attention:
- rm, back, or leg pain
- joint or muscle pain
- loss of appetite
- metallic taste in mouth
- passing of gas
- sore throat
- stomach upset
- stuffy or runny nose
Inform your healthcare provider immediately if you experience any serious side effects:
- fever, nausea, vomiting, loss of appetite, ongoing pain that begins in the upper left or middle of the stomach but may spread to the back
- shortness of breath, rapid weight gain, or swelling of feet or ankles
- itchy skin, skin blistering or peeling
- joint pain
- swelling of the face, lips, tongue, and throat
- difficulty in breathing or swallowing
Inform your doctor or pharmacist if you are allergic to sitagliptin or metformin, or if you have any other allergies before taking this medication. Inactive ingredients in the product may cause allergic reactions or other issues.
Before using this medication, tell your doctor or pharmacist about your medical history, especially if you have severe breathing problems, blood problems such as anemia or vitamin B12 deficiency, kidney disease, liver disease, pancreatitis, or gallstones.
You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Therefore, avoid driving, operating machinery, or engaging in activities that require alertness or clear vision until you are sure you can perform them safely.
While using this medication, limit your alcohol intake since it can raise the risk of lactic acidosis and developing low blood sugar.
Dehydration due to high fever, diuretics such as hydrochlorothiazide, too much sweating, diarrhea, or vomiting may increase the risk of lactic acidosis. Stop taking this medication and contact your doctor if you experience prolonged diarrhea or vomiting, and ensure you drink enough fluids to avoid dehydration.
When your body is stressed due to fever, infection, injury, or surgery, it may be harder to manage your blood sugar. Talk to your doctor because increased stress may necessitate a change in your treatment plan, medications, or blood sugar testing.
Older adults may have a higher risk of side effects, such as low blood sugar or lactic acidosis.
During pregnancy, only use this medication when necessary, and discuss the risks and benefits with your doctor. Your doctor may recommend insulin instead of this product during pregnancy, so follow their instructions carefully.
Metformin may cause changes in menstrual cycles (promote ovulation) and increase the risk of pregnancy. Consult your doctor or pharmacist about reliable birth control methods while using this medication.
Metformin passes into breast milk in small amounts, and it is uncertain whether sitagliptin does the same. Talk to your doctor before breast-feeding.
Form and Strength
Janumet is available in the following forms and strengths:
Is Janumet hard on kidneys?
Janumet may cause kidney problems as a side effect. Due to these risks, your doctor may not prescribe Janumet if you have kidney problems.
Does Janumet lower blood sugar immediately?
Depending on the dose, the medication starts working within 4 to 5 days, but the full effects of Janumet can take up to a few weeks in lowering your blood sugar.