Janumet XR (Sitagliptin/Metformin HCI XR) Customer Reviews

Janumet XR

Rx Prescription Required    RxFormulation : Extended Release Tablet

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The combination of metformin and sitagliptin is prescribed to treat elevated blood sugar levels associated with type 2 diabetes. Metformin exerts its effects by diminishing the absorption of sugar from the stomach, reducing the release of stored sugar from the liver, and enhancing the body’s utilization of sugar. Sitagliptin works by regulating blood sugar levels through an increase in substances that stimulate the pancreas to release more insulin. Additionally, it signals the liver to cease the production of sugar when blood sugar levels become excessive.

Uses and Dosage

Administer this medication orally according to your doctor’s instructions, typically once daily with a meal, preferably in the evening. Swallow the tablets whole; do not crush or chew them, as doing so can lead to the rapid release of the entire drug, increasing the risk of side effects.

Ensure an ample intake of fluids while taking this medication unless otherwise directed by your doctor.

The dosage is determined based on your medical condition, response to treatment, and concurrent use of other medications. To minimize the likelihood of side effects, such as an upset stomach, your doctor may advise you to start with a low dose and gradually increase it. Carefully follow your doctor’s instructions in this regard.

Consistency in taking this medication is vital to derive the maximum benefit from it. To aid in remembrance, take it at the same time each day. Diligently adhere to the medication treatment plan, meal plan, and exercise program recommended by your doctor.

Inform your doctor if your condition fails to improve or worsens, such as experiencing excessively high or low blood sugar levels.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • bloated or feeling of fullness
  • excess air or gas in the stomach or intestines
  • indigestion
  • lack or loss of strength
  • muscle aches
  • passing gas
  • sore throat
  • stuffy or runny nose
  • vomiting

Inform your healthcare provider immediately if you experience any serious side effects:

  • blurred vision
  • chills
  • cold sweats
  • confusion
  • cool, pale skin
  • depression
  • dizziness
  • fast heartbeat
  • headache
  • increased hunger
  • loss of consciousness
  • mental cloudiness
  • nausea
  • nightmares
  • not thinking clearly
  • seizures
  • shakiness
  • slurred speech
  • unusual tiredness or weakness


Before initiating this medication, inform your doctor or pharmacist if you have any allergies, especially to sitagliptin or metformin, or if you have any other allergies. This product may contain inactive ingredients that can trigger allergic reactions or other complications.

Prior to using this medication, discuss your medical history with your doctor or pharmacist, particularly if you have kidney disease, severe breathing problems, liver disease, pancreatitis, gallstones, or blood problems like anemia or vitamin B12 deficiency.

Be cautious about activities that demand alertness or clear vision as you may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Avoid driving, using machinery, or any other task that requires full attention until you are certain you can do so safely.

While taking this medication, limit alcohol consumption, as it can increase the risk of developing lactic acidosis, pancreatitis, and low blood sugar.

Certain conditions like high fever, using “water pills” (diuretics such as hydrochlorothiazide), excessive sweating, diarrhea, or vomiting may cause dehydration and increase the risk of lactic acidosis. If you experience prolonged diarrhea or vomiting, stop taking the medication and promptly inform your doctor. Make sure to drink enough fluids to prevent dehydration, unless your doctor advises otherwise.

During periods of stress on your body (e.g., due to fever, infection, injury, or surgery), it may be more challenging to control your blood sugar levels. In such cases, consult your doctor, as it may necessitate alterations to your treatment plan, medications, or blood sugar testing.

Older adults may be more susceptible to the side effects of this medication, particularly low blood sugar or lactic acidosis.

Metformin can affect the menstrual cycle by promoting ovulation and increasing the risk of becoming pregnant. If you are using this medication, consult your doctor or pharmacist about the use of reliable birth control methods.

During pregnancy, use this medication only when clearly needed, and discuss the potential risks and benefits with your doctor.

Pregnancy can cause or worsen diabetes. Develop a management plan with your doctor for controlling your blood sugar levels while pregnant. Your diabetes treatment, including diet and medications (including insulin), may require adjustments during pregnancy.

Metformin passes into breast milk, while it is uncertain if sitagliptin does. Consult your doctor before breastfeeding to make an informed decision.

Form and Strength

Janumet XR is available in the following forms and strengths:

  • Janumet XR extended-release tablet:

    • 50/500mg
    • 50/1000mg
    • 100/1000mg


Should Janumet XR be taken in the morning or at night?

It is better to take Janumet XR with your evening meal. Take Janumet XR one time each day by mouth with a meal to help lower your chance of having an upset stomach.

How quickly does Janumet XR work?

Depending on the dose, the medication starts working within 4 to 5 days, but the full effects of Janumet XR can take up to a few weeks in lowering your blood sugar and improving your A1c level.


  1. https://www.janumetxr.com/how-to-take-janumet-xr/#:~:text=It%20is%20better%20to%20take,as%20your%20doctor%20tells%20you
  2. https://www.goodrx.com/janumet/what-is#faqs
  3. https://www.medbroadcast.com/drug/getdrug/janumet-xr
  4. https://www.webmd.com/drugs/2/drug-159466/janumet-xr-oral/details
  5. https://www.mayoclinic.org/drugs-supplements/sitagliptin-and-metformin-oral-route/proper-use/drg-20070903?p=1
  6. https://www.drugs.com/mtm/janumet-xr.html

Additional information

Generic name:

Sitagliptin/Metformin HCI XR


Extended Release Tablet


50/500mg, 50/1000mg, 100/1000mg

Quantities Available:

28, 56, 60, 84, 112, 120, 168, 180

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Janumet XR (Sitagliptin/Metformin HCI XR). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Janumet XR (Sitagliptin/Metformin HCI XR).