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Formulation : 
Description
Indications
Sitagliptin is indicated for the management of elevated blood sugar levels in individuals with type 2 diabetes in conjunction with a suitable diet and exercise regimen, and potentially in combination with other medications. The management of high blood sugar levels assists in mitigating the risk of adverse health consequences such as kidney damage, loss of vision, neuropathies, amputations, and sexual dysfunction, while also reducing the likelihood of experiencing a heart attack or stroke.
Sitagliptin is classified as an antidiabetic medication that operates by augmenting the concentration of endogenous incretin hormones. Incretins act by stimulating the release of insulin, particularly following meals, thereby moderating blood glucose levels. They also exert an inhibitory effect on hepatic glucose production, leading to a reduction in overall blood glucose levels.
Uses and Dosage
Sitagliptin is administered orally in the form of a tablet. Typically, it is taken once daily, either with or without food, at approximately the same time every day. Adhere to the prescribed dosage and frequency of intake, as directed on the medication label, and consult with your doctor or pharmacist for clarification if needed. Take sitagliptin exactly as directed, without altering the dosage or frequency, unless advised to do so by your physician.
While sitagliptin is effective in regulating high blood sugar levels, it does not serve as a cure for diabetes. Continue taking the medication even if you feel healthy. Abrupt cessation of sitagliptin must be avoided, and any changes in medication should only be made in consultation with your doctor.
Side Effects
Some side effects may occur that usually do not need medical attention:
- stuffed or runny nose
- sore throat
- headache
- diarrhea
- nausea
Inform your healthcare provider immediately if you experience any serious side effects:
- fever
- nausea
- vomiting
- loss of appetite
- ongoing pain that begins in the upper left or middle of the stomach but may spread to the back
- shortness of breath
- rapid weight gain, or swelling of feet or ankles
- itchy skin, skin blistering or peeling
- joint pain
- rash
- hives
- swelling of the face, lips, tongue, and throat
- difficulty in breathing or swallowing
Caution
Prior to initiating treatment with sitagliptin, inform your doctor or pharmacist of any allergies you may have, including allergies to the medication itself or any of its inactive components. These inactive components have the potential to trigger allergic reactions or other adverse effects, and therefore require careful consideration.
Provide your doctor or pharmacist with your medical history, particularly if you have a history of kidney disease, heart failure, pancreatitis, or gallstones.
In some instances, you may experience blurred vision, dizziness, or drowsiness as a result of extremely high or low blood sugar levels. Refrain from activities that require alertness or clear vision, such as driving or operating machinery, until you are confident that you can perform them safely.
Limiting alcohol intake is advised while taking sitagliptin, as it can increase your risk of developing low blood sugar.
Stressful situations such as fever, infection, injury, or surgery may make it more difficult to regulate your blood sugar levels. In such cases, consult with your doctor, as increased stress may require modifications to your treatment plan, medication regimen, or blood sugar testing.
During pregnancy, sitagliptin should only be used when absolutely necessary. Pregnancy can cause or exacerbate diabetes. Discuss a management plan with your doctor to regulate blood sugar levels while pregnant. Your doctor may alter your diabetes treatment during pregnancy, and it is necessary to discuss the advantages and disadvantages of various treatments, such as diet, exercise, and medications including insulin.
The transfer of this medication into breast milk is unknown. Consult with your doctor before breastfeeding while taking sitagliptin.
Form and Strength
Januvia is available in the following forms and strengths:
-
Januvia film-coated tablet:
- 25mg
- 50mg
- 100mg
-
sitagliptin tablet:
- 25mg
- 50mg
- 100mg
FAQ
Is it better to take Januvia in the morning or at night?
Januvia is generally well-tolerated, but it’s best to be consistent with the time of day you take Januvia. It doesn’t matter if you prefer to take it in the morning or at night.
How quickly does Januvia lower blood sugar?
Januvia works quickly to lower blood sugar, probably within the first one to two weeks. However, the full beneficial effect with Januvia may take several months.
Resources
- https://www.goodrx.com/januvia/best-time-to-take-januvia
- https://www.drugs.com/medical-answers/long-januvia-work-3541314/#:~:text=Januvia%20works%20quickly%20to%20lower,as%20prescribed%20by%20your%20doctor
- https://www.medbroadcast.com/drug/getdrug/januvia#adverseeffects
- https://www.webmd.com/drugs/2/drug-145704/januvia-oral/details
- https://medlineplus.gov/druginfo/meds/a606023.html
- https://www.drugs.com/januvia.html
