The combination of linagliptin and metformin is prescribed to treat elevated blood sugar levels resulting from type 2 diabetes. Linagliptin aids in regulating blood sugar levels by increasing substances in the body that stimulate the pancreas to release more insulin. It additionally signals the liver to halt sugar production when blood sugar levels are excessively high. Metformin reduces the absorption of sugar from the stomach, diminishes the release of stored sugar from the liver, and improves the body’s utilization of sugar. Together, these medications work synergistically to help manage and control blood sugar levels in patients with type 2 diabetes.
Uses and Dosage
Administer this medication orally according to your doctor’s instructions, typically twice daily with meals. While taking this medication, ensure an adequate intake of fluids, unless your doctor advises otherwise.
The dosage of this medication is determined based on your medical condition, response to treatment, and any other medications you may be taking. To minimize the risk of side effects, such as upset stomach, your doctor may recommend starting with a low dose and gradually increasing it. Follow your doctor’s instructions carefully in this regard.
For optimal benefits, maintain a regular dosing schedule and take the medication at the same times each day. Utilize reminders to help you remember the dosing times. Diligently adhere to the medication treatment plan, meal plan, and exercise program prescribed by your doctor.
If you notice that your condition does not improve or worsens, such as experiencing excessively high or low blood sugar levels, promptly inform your doctor.
Some side effects may occur that usually do not need medical attention:
- excess air or gas in the stomach or intestines
- feeling of fullness
- lack or loss of strength
- muscle aches
- passing gas
- sore throat
- stuffy or runny nose
Inform your healthcare provider immediately if you experience any serious side effects:
- blurred vision
- cold sweats
- cool, pale skin
- fast heartbeat
- increased hunger
- loss of consciousness
- slurred speech
- unusual tiredness or weakness
Before starting this medication, inform your doctor or pharmacist if you have any allergies, particularly to linagliptin or metformin, or if you have any other allergies. This product may contain inactive ingredients that can trigger allergic reactions or other complications.
Prior to using this medication, discuss your medical history with your doctor or pharmacist, especially if you have kidney disease, severe breathing problems, liver disease, pancreatitis, gallstones, or blood problems like anemia or vitamin B12 deficiency.
Be cautious about activities that demand alertness or clear vision, as you may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Avoid driving, using machinery, or any other task that requires full attention until you are certain you can do so safely.
While taking this medication, limit alcohol consumption, as it can increase the risk of developing lactic acidosis, pancreatitis, and low blood sugar.
Certain conditions like high fever, using “water pills” (diuretics such as hydrochlorothiazide), excessive sweating, diarrhea, or vomiting may cause dehydration and increase the risk of lactic acidosis. If you experience prolonged diarrhea or vomiting, stop taking the medication and promptly inform your doctor. Make sure to drink enough fluids to prevent dehydration, unless your doctor advises otherwise.
During periods of stress on your body (e.g., due to fever, infection, injury, or surgery), it may be more challenging to control your blood sugar levels. In such cases, consult your doctor, as it may necessitate alterations to your treatment plan, medications, or blood sugar testing.
Older adults may be more susceptible to the side effects of this drug, particularly low blood sugar or lactic acidosis.
Metformin can affect the menstrual cycle by promoting ovulation and increasing the risk of becoming pregnant. If you are using this medication, consult your doctor or pharmacist about the use of reliable birth control methods.
During pregnancy, use this medication only when clearly needed, and discuss the potential risks and benefits with your doctor.
Pregnancy can cause or worsen diabetes. Develop a management plan with your doctor for controlling your blood sugar levels while pregnant. Your diabetes treatment, including diet and medications, may require adjustments during pregnancy.
Metformin passes into breast milk, while it is uncertain if linagliptin does. Consult your doctor before breastfeeding to make an informed decision.
Form and Strength
Jentadueto is available in the following forms and strengths:
Can I use insulin if I’m taking Jentadueto?
It’s possible that your provider might prescribe Jentadueto and insulin for you at the same time. Be mindful that taking Jentadueto with insulin or other medications that lower your blood sugar level puts you at risk for having dangerously low blood sugar levels.
Should Jentadueto be taken before or after food?
Jentadueto should be taken twice daily with meals to reduce the gastrointestinal adverse reactions associated with metformin.