Transdermal patches containing rotigotine are utilized to address the symptoms of Parkinson’s disease (PD). These symptoms encompass bodily tremors, muscle rigidity, reduced movement speed, and balance complications. Rotigotine transdermal patches are additionally employed in the treatment of restless legs syndrome (RLS) or Ekbom syndrome. Rotigotine falls within the category of medications referred to as dopamine agonists. Its mechanism involves substituting dopamine, a naturally occurring brain compound essential for regulating movement.
Uses and Dosage
The transdermal rotigotine patch is designed for application onto the skin. It’s typically used once daily, ideally at the same time each day.
Your doctor will likely initiate treatment with a low rotigotine dose, gradually increasing it, typically no more frequently than once a week.
Rotigotine effectively manages the symptoms of Parkinson’s disease and restless legs syndrome, but it doesn’t provide a cure. It might take several weeks before the full benefits of rotigotine are evident. Continue using the patches even if you feel well. Avoid discontinuing their use without consulting your doctor. Sudden cessation of rotigotine patches could result in fever, confusion, muscle stiffness, changes in emotional state, anxiety, depression, fatigue, sleep disturbances, sweating, or discomfort. Your doctor will likely taper your dose gradually.
Apply the patch to areas like the stomach, thigh, hip, flank, shoulder, or upper arm. The skin should be clean, dry, and healthy. Avoid applying the patch to oily, red, irritated, or injured skin. Refrain from using creams, lotions, oils, powders, or ointments on the application site. Avoid skin folds or areas that might rub against tight clothing or waistbands. If applying to a hairy area, shave it at least 3 days prior. Vary the patch location daily, moving from one side of the body to the other or from upper to lower body. Don’t use the same spot more often than every 14 days.
While wearing the patch, keep the area away from sources of heat like heating pads, electric blankets, heated waterbeds, and direct sunlight. Avoid hot baths and saunas.
Ensure the patch stays in place during bathing or physical activity. If edges lift, secure with tape. If it falls off, replace it with a new patch in a different spot for the rest of the day. The following day, remove that patch and apply a new one as usual.
If the covered skin area becomes irritated or develops a rash, avoid direct sunlight until the skin heals to prevent changes in skin color.
Never cut or damage a rotigotine patch.
Some side effects may occur that usually do not need medical attention:
- rash, redness, swelling or itching of the skin that was covered by the patch
- loss of appetite
- difficulty falling asleep or staying asleep
- abnormal dreams
- dizziness or feeling that you or the room is moving
- weight gain
- swelling of the hands, feet, ankles, or lower legs
- increased sweating
- dry mouth
- loss of energy
- joint pain
- abnormal vision
- sudden movements of legs or worsening of symptoms of PD or RLS
- rapid or irregular heartbeat
Inform your healthcare provider immediately if you experience any serious side effects:
- difficulty breathing or swallowing
- seeing things or hearing voices that do not exist (hallucinating)
- feeling unusually suspicious of others
- aggressive or unfriendly behavior
- having strange thoughts or beliefs that have no basis in reality
- frenzied or abnormally excited mood
Before initiating rotigotine, inform your doctor or pharmacist about any allergic reactions you may have, whether to this medication or other allergens. This product might consist of inactive ingredients like sulfites that could trigger allergic reactions or other issues.
Prior to using this medication, share your medical history with your doctor or pharmacist, particularly if you have asthma, sleep disorders such as sleep apnea or narcolepsy, high or low blood pressure, heart conditions like heart failure, kidney disease, or mental/mood disorders like schizophrenia.
This medication may induce dizziness or drowsiness. Alcohol or marijuana can intensify these effects. Avoid driving, operating machinery, or engaging in activities requiring alertness until you can do so safely.
While wearing the patch, refrain from exposing it to direct heat sources like heating pads, electric blankets, heat lamps, saunas, hot tubs, heated waterbeds, or prolonged sunlight. Heat exposure could lead to increased drug release into your body, heightening the risk of side effects.
If you’re scheduled for an MRI test or cardioversion, inform the healthcare provider about your patch usage. Some patches may contain metals that pose a burn risk during MRI or cardioversion procedures. Consult your doctor to determine whether you should remove the patch before the procedure and how to reapply it properly afterward.
Elderly individuals may exhibit heightened sensitivity to the drug’s side effects, particularly mental/mood changes such as hallucinations.
During pregnancy, use this medication only if clearly necessary. Discuss the potential risks and benefits with your doctor.
It’s unclear whether this drug passes into breast milk. Additionally, it might decrease the amount of breast milk produced. Consult your doctor before breastfeeding.
Form and Strength
Neupro is available in the following forms and strengths:
How long can you use a single Neupro patch?
The patch remains on the skin for 24 hours and will then be replaced by a new one at a different site of application.
How long does it take for the Neupro patch to start working?
It may take several weeks before you reach the dose that controls your symptoms best.