Elagolix is utilized for the management of pain associated with endometriosis, a gynecological condition characterized by the presence of endometrial tissue outside the uterus, leading to symptoms such as infertility, dysmenorrhea, dyspareunia, and abnormal uterine bleeding.
Elagolix belongs to the class of gonadotropin-releasing hormone (GnRH) receptor antagonists, and exerts its therapeutic effects by reducing the levels of specific hormones in the body.
Uses and Dosage
Prior to initiating this medication, your physician may conduct a pregnancy test or instruct you to commence treatment within 7 days of the onset of your menstrual period to confirm that you are not pregnant.
Follow your doctor’s instructions regarding the timing and administration of this medication.
Take this medication orally, with or without food, as prescribed by your physician, usually once or twice daily. The dosage and duration of treatment will be determined based on your medical condition, response to treatment, and concurrent use of other medications.
Inform your doctor and pharmacist about all products you are using, including prescription drugs, over-the-counter drugs, and herbal products.
To mitigate the risk of bone loss, this medication is typically prescribed for a duration of up to 6 months or up to 24 months, as advised by your doctor.
Adhere to a regular dosing schedule to maximize the therapeutic benefits of this medication, taking it at the same time(s) each day to aid in remembering.
Notify your doctor if your condition does not improve or worsens despite treatment.
Some side effects may occur that usually do not need medical attention:
- hot flashes
- night sweats
- stomach pain
- weight gain
- difficulty falling sleeping or staying asleep
- changes in menstrual periods
- joint pain
- changes in sexual desire
Inform your healthcare provider immediately if you experience any serious side effects:
- yellow of skin or eyes
- dark colored urine
- extreme tiredness
- nausea and vomiting
- right upper abdomen pain
- unusual bleeding or bruising
Prior to initiating elagolix, disclose to your doctor or pharmacist any known allergies you may have, including allergies to elagolix or other inactive ingredients present in the product that could potentially cause allergic reactions or other adverse effects.
Before using this medication, provide your doctor or pharmacist with your complete medical history, particularly if you have a history of liver problems, bone loss (osteoporosis), or mental/mood disorders such as depression.
Elagolix must not be used during pregnancy as it may pose harm to an unborn baby. Inquire about reliable non-hormonal methods of birth control, such as condoms or spermicide, while using this medication and for 4 weeks after discontinuing treatment.
Due to the potential impact of this medication on menstruation, it may be more challenging to discern if you are pregnant. If you suspect that you may be pregnant or become pregnant while on this medication, promptly notify your doctor.
The passage of this medication into breast milk is not well understood. Consult your doctor before breastfeeding while taking elagolix.
Form and Strength
Orilissa is available in the following forms and strengths:
How long does it take to adjust to Orilissa?
Orilissa starts working in the body to lower estrogen after about 24 hours; however, pain relief will take longer. It may take 3 months to experience the full benefits of endometriosis pain relief.
Do you still ovulate on Orilissa?
Studies show that women using Orilissa have lower ovulation rates but may still ovulate.