Pristiq (Desvenlafaxine) Customer Reviews


Rx Prescription Required    RxFormulation : Extended Release Tablet

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Generic alternative for Pristiq


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Desvenlafaxine is an antidepressant medication belonging to the class of selective serotonin and norepinephrine reuptake inhibitors (SNRIs). Its mechanism of action involves elevating the levels of serotonin and norepinephrine, which are natural neurotransmitters in the brain responsible for regulating mood and emotions, and promoting mental balance.

Uses and Dosage

Please take this medication orally as instructed by your physician, usually once daily, with or without food. The dosage is based on your medical condition and response to treatment.

Do not chew, crush, or dissolve this medication in water, as doing so can cause the entire dose to be released at once, increasing the risk of side effects. Swallow the tablets whole.

To minimize the risk of side effects, your doctor may advise you to start with a low dose and gradually increase your dosage. Carefully follow your doctor’s directions. Do not increase your dose or take this medication more frequently or for longer than prescribed. Doing so will not improve your condition any faster and may increase your risk of side effects.

Use this medication regularly to achieve the best possible outcome. Take it at the same time every day to help you remember.

Continue taking this medication even if you feel well. Do not stop taking it without consulting your doctor. Suddenly discontinuing this drug can exacerbate certain conditions, leading to symptoms such as mood swings, headache, blurred vision, tiredness, sleep disturbances, and brief sensations similar to electric shock. To avoid these symptoms during the withdrawal process, your doctor may gradually lower your dose.

If you are switching from another antidepressant to desvenlafaxine, your doctor should gradually reduce the dosage of your previous antidepressant to prevent withdrawal symptoms. Consult your doctor or pharmacist for more information.

It may take several weeks before you feel the full therapeutic effects of this medication. If your condition does not improve or worsens, inform your doctor.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • constipation
  • loss of appetite
  • dry mouth
  • dizziness
  • sleepiness
  • extreme tiredness
  • unusual dreams
  • yawning
  • difficulty falling asleep or staying asleep
  • sweating
  • uncontrollable shaking of a part of the body
  • pain, burning, numbness, or tingling in part of the body
  • enlarged pupils
  • sexual problems in males: decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation
  • sexual problems in females: decreased sex drive, or delayed orgasm or unable to have an orgasm
  • difficulty urinating

Inform your healthcare provider immediately if you experience any serious side effects:

  • rash
  • hives
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • difficulty swallowing or breathing
  • fast heartbeat
  • cough
  • chest, arm, back, neck, or jaw pain
  • fever
  • coma (loss of consciousness for a period of time)
  • seizures
  • fever, sweating, confusion, fast or irregular heartbeat, severe muscle stiffness or twitching, agitation, hallucinations, loss of coordination, nausea, vomiting, or diarrhea
  • unusual bleeding or bruising
  • nosebleeds
  • small red or purple dots on the skin
  • headache
  • difficulty concentrating
  • memory problems
  • confusion
  • weakness
  • increased falls
  • fainting


Prior to taking desvenlafaxine, inform your doctor or pharmacist if you have any allergies to desvenlafaxine, venlafaxine, or any other medications. This product may include inactive components that can provoke allergic reactions or other issues.

Prior to taking this medication, inform your doctor or pharmacist of your medical history, particularly if you have a personal or family history of psychiatric conditions, suicide attempts, bleeding disorders, glaucoma (angle-closure type), high blood pressure, heart issues, a history of stroke, high cholesterol, kidney disease, liver disease, seizure disorder, or low sodium in the blood (hyponatremia).

This medication may cause dizziness, drowsiness, or blurred vision. Alcohol or marijuana may intensify these effects. Do not operate heavy machinery, drive, or engage in activities requiring alertness or clear vision until it is safe to do so.

Older adults may experience increased sensitivity to the side effects of this medication, especially dizziness when standing. Older adults may also be more likely to experience a type of salt imbalance (hyponatremia), particularly if they are taking diuretics (water pills). Dizziness and salt imbalances can increase the likelihood of falls. Older adults may also be at greater risk of bleeding when using this medication.

Based on data for a similar medication (venlafaxine), children may be more vulnerable to the side effects of this drug, especially loss of appetite and weight loss. Children taking this medication should have their height and weight monitored.

During pregnancy, this medication should only be used if it is clearly needed, as it may be harmful to an unborn baby. Newborns born to mothers who used this drug during the last three months of pregnancy may rarely develop withdrawal symptoms such as breathing/feeding difficulties, muscle stiffness, seizures, or constant crying. Notify your doctor immediately if you observe any of these symptoms in your newborn.

Since untreated mental/mood problems can be a serious condition, do not discontinue taking this medication unless directed to do so by your doctor. If you are contemplating pregnancy, become pregnant, or believe you may be pregnant, discuss the benefits and hazards of using this medication during pregnancy with your doctor right away.

This medication passes into breast milk and may have unwanted effects on a nursing infant. Consult with your doctor before breastfeeding.

Form and Strength

Pristiq is available in the following forms and strengths:

  • Pristiq extended-release tablet:

    • 50mg
    • 100mg
  • desvenlafaxine extended-release tablet:

    • 50mg


Is Pristiq a strong antidepressant?

Pristiq is an antidepressant medication that works by increasing the absorption of norepinephrine and serotonin in the brain. Pristiq is very powerful.

Do you gain weight on Pristiq?

While weight gain is possible from Pristiq, it’s very unlikely. In studies, people taking Pristiq for depression generally didn’t have notable changes in their weight.



Additional information

Generic name:



Extended Release Tablet


25mg, 50mg, 100mg

Quantities Available:

28, 30, 84, 90, 100

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Pristiq (Desvenlafaxine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Pristiq (Desvenlafaxine).