Synjardy (Empagliflozin/metformin hcl) Customer Reviews


Rx Prescription Required    RxFormulation : Film Coated Tablet

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This medication contains a combination of empagliflozin and metformin. Its primary purpose is to assist individuals with type 2 diabetes in managing their high blood sugar levels along with proper diet and exercise. This medication’s efficacy in controlling high blood sugar helps prevent various complications such as kidney damage, nerve problems, blindness, loss of limbs, and sexual function issues.

Empagliflozin works in the kidneys to prevent absorption of glucose (blood sugar). This helps lower the blood sugar level. Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. By regulating diabetes, the risk of heart attacks and strokes may also decrease.

Uses and Dosage

Follow your doctor’s instructions and take this medication orally, usually twice a day with meals. The dosage will be determined by your medical condition, response to treatment, and any other medications you are currently taking.

Your doctor may recommend starting this medication at a low dose and gradually increasing it to reduce the risk of side effects like diarrhea, nausea, and vomiting. Adhere to your doctor’s instructions and take the medication regularly to reap the maximum benefits. To help you remember, take it at the same time each day.

Contact your doctor if your condition does not improve or worsens, such as experiencing high or low blood sugar levels.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • bloated or feeling of fullness
  • diarrhea
  • excess air or gas in stomach or bowels
  • indigestion
  • passing gas
  • stomach discomfort

Inform your healthcare provider immediately if you experience any serious side effects:

  • bladder pain
  • bloody or cloudy urine
  • blurred vision
  • chills
  • confusion
  • cool, pale skin
  • decreased appetite
  • difficult, burning, or painful urination
  • discouragement
  • dizziness
  • fast heartbeat
  • fast, shallow breathing
  • feeling sad or empty
  • frequent urge to urinate
  • general feeling of discomfort
  • headache
  • increased hunger
  • irritability
  • lack of appetite
  • loss of consciousness
  • loss of interest or pleasure
  • lower back or side pain
  • muscle pain or cramping
  • nausea
  • nightmares
  • seizures
  • shakiness
  • sleepiness
  • slurred speech
  • stomach discomfort
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • unusual tiredness or weakness


Prior to taking this medication, inform your doctor or pharmacist if you have allergies to empagliflozin or metformin or any other allergies. This medication may contain inactive components that can cause an allergic reaction or other issues.

Before using this medication, notify your doctor or pharmacist of your medical history, specifically of breathing problems like asthma, obstructive lung disease, kidney or liver disease, alcohol use/abuse, yeast infections in the vagina or penis, dehydration, heart disease like heart failure or recent heart attack, or blood problems like anemia or vitamin B12 deficiency.

Low or high blood sugar can cause blurred vision, dizziness, or drowsiness. Therefore, until you are confident you can perform activities safely, avoid driving, using machinery, or any other activities that require alertness or clear vision.

While taking this medication, limit your alcohol intake as it increases your risk of developing lactic acidosis, low blood sugar, and a high ketone level.

Dehydration resulting from high fever, “water pills” (diuretics like hydrochlorothiazide), too much sweating, diarrhea, or vomiting can increase your risk of lactic acidosis. In case of prolonged diarrhea or vomiting, discontinue this medication and inform your doctor immediately. Unless your doctor advises otherwise, drink sufficient fluids to prevent dehydration.

During illness, stress, injury, or surgery, it may become difficult to control your blood sugar, leading to a high ketone level. Consult your doctor as this may necessitate a change in your treatment plan, medications, or blood sugar or ketone testing.

Older adults are more susceptible to the side effects of this medication, particularly low blood sugar, dehydration, lactic acidosis, kidney issues, and low blood pressure.

Use this medication during pregnancy only when needed. Consult your doctor to weigh the risks and benefits.

Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar during pregnancy, which may include altering your diabetes treatment (such as insulin and diet).

Metformin can alter the menstrual cycle, promote ovulation, and increase the chances of becoming pregnant. Consult your doctor or pharmacist about reliable birth control while using this medication.

Metformin passes into breast milk in small quantities. The amount of empagliflozin that passes into breast milk is unknown. Consult your doctor before breastfeeding.

Form and Strength

Synjardy is available in the following forms and strengths:

  • Synjardy tablet:

    • 5/500mg
    • 12.5/500mg
    • 5/1000mg
    • 12.5/1000mg


Does Synjardy cause frequent urination?

Synjardy can cause frequent urination as a side effect.

How long does it take for Synjardy to start working?

The beneficial effect of Synjardy on your blood sugar levels may begin quickly, within the first 1 to 2 weeks.



Additional information

Generic name:

Empagliflozin/Metformin hcl, Empagliflozin/metformin hcl


Film Coated Tablet, Tablet


5/500mg, 5/1000mg, 12.5/500mg, 12.5/1000mg

Quantities Available:

60, 120, 180

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Synjardy (Empagliflozin/metformin hcl). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Synjardy (Empagliflozin/metformin hcl).