Synjardy (Empagliflozin/metformin hcl) Customer Reviews


Rx Prescription Required    RxFormulation : Film Coated Tablet

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This prescription medicine is a drug that combines empagliflozin and metformin and is prescribed to improve blood sugar levels in people with type 2 diabetes. This is best taken in combination with diet and exercise. Empagliflozin aids in the removal of glucose from the circulation via the kidneys. Metformin reduces glucose synthesis in the liver and decreases glucose absorption in the intestines. 

What is Synjardy used for?  

  • With diet and exercise, this medication can help people with type 2 diabetes better manage their blood sugar levels. 
  • In individuals with type 2 diabetes and heart disease, this medicine is also used to reduce the risk of mortality from a heart attack, stroke, or heart failure. 

Synjardy Dosing

This oral tablet comes in four dosing strengths: Synjardy 12.5 mg 1000 mg (two tablets once daily), 12.5 mg 500 mg (one tablet twice daily), 5 mg 500 mg (one tablet twice daily), 5 mg 1000 mg (two tablets twice daily). 


  • The dosage should be tailored to the patient’s existing regimen, efficacy, and tolerability, utilizing the recommended daily dose of empagliflozin of 10 mg or 25 mg, while not exceeding the maximum recommended daily dose of metformin. 
  • To decrease the gastrointestinal side effects of metformin, Synjardy should be taken twice daily with meals. 
  • A patient who is overweight should stick to their energy-restricted diet. 

Synjardy Side Effects

The following are some of the most common side effects: 

  • Blood sugar levels are low 
  • Indigestion, stomach discomfort, gas, nausea, vomiting, and diarrhea are all symptoms of indigestion. 
  • Bladder infection  
  • Women’s yeast infection; 
  • Headaches, exhaustion; or 
  • Sore throat, runny or stuffy nose


  • Lactic acidosis is a dangerous disease induced by this prescription drug. If you have even moderate symptoms like muscle pain or weakness, numbness or coldness in your arms and legs, difficulties breathing, stomach discomfort, nausea, vomiting, irregular heartbeats, dizziness, or feeling of weakness or exhaustion, get emergency medical attention. 
  • This drug can cause significant infections in the genital area in rare situations. If you have burning, itching, odor, discharge, discomfort, tenderness, redness, or swelling of the vaginal or rectal area, fever, or don’t feel well, seek medical attention immediately. 

Frequently Asked Questions

-What is Synjardy XR?  

Synjardy XR carries the same combination of drugs as Synjardy, but with an extended-release coating. This is taken once daily, in the mornings with food to lower the chance of an upset stomach. 

Is one of the side effects of Synjardy, weight loss? 

People using the combination of empagliflozin and metformin lost 2-3 percent of their body weight on average in trials of patients with type 2 diabetes. 

-What are Synjardy alternatives? 

If the 5 mg/500 mg is temporarily unavailable, switching patients to metformin 500 mg twice daily and Jardiance 10 mg once daily is an alternative. 


Additional information

Generic name:

Empagliflozin/Metformin hcl, Empagliflozin/metformin hcl


Film Coated Tablet, Tablet


5/500mg, 5/1000mg, 12.5/500mg, 12.5/1000mg

Quantities Available:

60, 120, 180

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Synjardy (Empagliflozin/metformin hcl). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Synjardy (Empagliflozin/metformin hcl).