Synjardy XR (Empagliflozin/Metfromin hcl) Customer Reviews

Synjardy XR

Rx Prescription Required    RxFormulation : ER Tablet

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This medicine contains two active ingredients – empagliflozin and metformin. In conjunction with a well-regulated dietary and exercise regimen, it serves as an integral component in the management of elevated blood glucose levels among individuals diagnosed with type 2 diabetes. Control of hyperglycemia contributes significantly to the prevention of complications such as renal impairment, visual impairment, neuropathy, extremity amputations, and sexual dysfunction.

Empagliflozin and metformin are also useful in the treatment of heart failure within the subset of type 2 diabetes patients. It performs the dual role of mitigating the risk of mortality attributed to heart disease and reducing the necessity for hospitalization due to heart failure exacerbations. The mechanism of action of this medication primarily revolves around the restoration of the body’s innate responsiveness to natural insulin secretion.

Uses and Dosage

Administer this medication orally in accordance with your healthcare provider’s instructions, typically once daily during your morning meal. Ingest the tablets whole, avoiding any crushing, dissolving, or chewing, as such actions could lead to a rapid release of the entire drug dose, thereby elevating the potential for adverse effects.

Consistency in taking this medication is pivotal for optimizing its therapeutic benefits, adhere to a consistent daily schedule.

Ensure adequate fluid intake unless otherwise specified by your healthcare provider.

The prescribed dosage is contingent upon your specific medical condition, individual response to treatment, and concurrent medication usage. In order to mitigate the likelihood of side effects such as diarrhea or nausea, your doctor may advise commencing treatment with a lower dose and gradually escalating it. Be meticulous in following your doctor’s directives in this regard.

Should your condition fail to exhibit improvement or deteriorate, characterized by either elevated or diminished blood sugar levels, promptly inform your doctor.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • headache
  • stomach pain
  • gas
  • indigestion
  • nausea
  • vomiting
  • diarrhea
  • weakness
  • runny nose
  • sore throat

Inform your healthcare provider immediately if you experience any serious side effects:

  • difficulty breathing
  • swelling of your face, lips, tongue, or throat
  • fever
  • feeling unwell
  • little or no urination
  • dizziness
  • weakness
  • lightheadedness
  • nausea
  • vomiting
  • stomach pain
  • confusion
  • unusual drowsiness
  • unusual muscle pain
  • trouble breathing
  • stomach pain
  • irregular heart rate
  • feeling cold
  • tiredness
  • pain or burning when you urination
  • increased urination
  • blood in your urine
  • pain in your pelvis or back


Prior to initiating this medication, inform your healthcare provider or pharmacist of any known allergies you have, particularly if you are allergic to empagliflozin or metformin, or if you have any other known allergies. This product may contain inactive components that can potentially trigger allergic reactions or other adverse effects.

Before commencing treatment with this medication, provide your doctor or pharmacist with a comprehensive account of your medical history, with special attention to any history of respiratory issues, blood-related disorders, dehydration, cardiac conditions, kidney impairments, liver complications, as well as any history of alcohol use or abuse, and past episodes of yeast infections in the genital area.

You may encounter instances of blurred vision, dizziness, or drowsiness attributed to severely low or high blood sugar levels. During such episodes, refrain from operating machinery, driving, or engaging in activities necessitating alertness or clear vision until you are certain of your ability to do so safely.

While utilizing this medication, restrict alcohol consumption, as it may elevate the risk of developing lactic acidosis, low blood sugar, or a high level of ketones.

Dehydration can potentially result from circumstances such as a high fever, use of diuretics (like hydrochlorothiazide), excessive perspiration, diarrhea, or vomiting, thereby increasing the likelihood of lactic acidosis. In the event of persistent diarrhea or vomiting, discontinue medication use and promptly notify your doctor. Ensure adequate fluid intake to prevent dehydration, unless otherwise instructed by your healthcare provider.

Stressful situations, including fever, infections, injuries, or surgical procedures, may hinder blood sugar control. Likewise, reduced food intake due to illness or such circumstances can lead to elevated ketone levels while taking this medication. Consult your doctor in such cases, as they may necessitate adjustments to your treatment plan, medications, or blood sugar and ketone monitoring.

Older adults may be more susceptible to side effects, including low blood sugar, dehydration, lactic acidosis, kidney issues, and low blood pressure.

During pregnancy, the use of this medication should only occur when it is essential. Discuss the potential risks and benefits with your healthcare provider.

Pregnancy can either induce or exacerbate diabetes. Collaborate with your doctor to establish a comprehensive strategy for managing blood sugar levels during pregnancy. Your diabetes treatment plan may necessitate modifications during this period, encompassing dietary adjustments and alterations to medications, including insulin.

Metformin has the capacity to influence the menstrual cycle, promoting ovulation and increasing the likelihood of pregnancy. Seek guidance from your doctor or pharmacist regarding the implementation of reliable birth control methods while using this medication.

Metformin can be excreted into breast milk in minimal amounts, while the passage of empagliflozin into breast milk remains uncertain. Consult your healthcare provider prior to commencing breastfeeding.

Form and Strength

Synjardy XR is available in the following forms and strengths:

  • Synjardy XR extended-release tablet:

    • 12.5/1000mg
    • 25/1000mg


Can I take Synjardy XR if I’m over 65 years old?

There are no restrictions on taking Synjardy if you’re 65 years and older, but people in this age group might need to have their kidneys monitored more often while on treatment.

What is the difference between Synjardy and Synjardy XR?

Synjardy is an immediate-release form of the medication that is taken twice daily. Synjardy XR is an extended-release form that slowly releases the medication into your body throughout the day, so it’s taken once daily.



Additional information

Generic name:

Empagliflozin/Metfromin hcl


ER Tablet


12.5/1000mg, 25/1000mg

Quantities Available:


Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Synjardy XR (Empagliflozin/Metfromin hcl). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Synjardy XR (Empagliflozin/Metfromin hcl).