Trintellix (Vortioxetine) Customer Reviews


Rx Prescription Required    RxFormulation : Film Coated Tablet

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Generic alternative for Trintellix


Rx Prescription Required    RxFormulation : Film Coated Tablet

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Vortioxetine is indicated for the treatment of depression. Its mechanism of action involves facilitating the restoration of a specific naturally occurring neurotransmitter (serotonin) balance in the brain.

Vortioxetine functions as a selective serotonin reuptake inhibitor (SSRI) and a serotonin receptor modulator. This medication has the potential to enhance mood, sleep, appetite, and energy levels, and may aid in the rekindling of interest in daily activities.

Uses and Dosage

Vortioxetine is administered orally in tablet form and is typically taken once daily, with or without food, at the same time each day. Follow the instructions on the prescription label precisely, and to seek clarification from your physician or pharmacist on any unclear aspects.

Vortioxetine should be taken exactly as prescribed and the dose should not be increased or decreased, nor the frequency of administration altered, without consulting your physician.

The dose of vortioxetine may be adjusted by your doctor depending on your response to treatment and any associated side effects.

The full benefits of vortioxetine may take up to 2-4 weeks or longer to manifest. Continue taking vortioxetine even if you feel better, and to not discontinue its use without first consulting with your doctor.

Your doctor will typically reduce your dose gradually to minimize the risk of withdrawal symptoms, which may include headache, mood changes, irritability, agitation, nausea, dizziness, burning, numbness, or tingling in the hands or feet, anxiety, confusion, sweating, shaking, frenzied or abnormally excited mood, ringing in the ears, tiredness, difficulty falling asleep or staying asleep, and seizures. Any such symptoms experienced while reducing your dose of vortioxetine or shortly after discontinuation should be reported to your doctor.

Side Effects

Vortioxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • diarrhea
  • constipation
  • gas
  • dry mouth
  • dizziness
  • unusual dreams
  • sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation
  • sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm

Inform your healthcare provider immediately if you experience any serious side effects:

  • rash
  • hives
  • itching
  • swelling of the eyes, face, lips, tongue, or throat
  • hoarseness
  • difficulty breathing or swallowing
  • unusual bruising or bleeding
  • fever, sweating, confusion, fast or irregular heartbeat, severe muscle stiffness or twitching, agitation, hallucinations, loss of coordination, nausea, vomiting, or diarrhea
  • nosebleed
  • headache
  • difficulty concentrating
  • memory problems
  • confusion
  • weakness
  • unsteadiness
  • hallucinations
  • fainting
  • seizures
  • loss of consciousness


Prior to initiating treatment with vortioxetine, inform your healthcare provider or pharmacist of any known allergies to the medication or other substances. The product may contain inactive ingredients that have the potential to cause an allergic reaction or other adverse effects.

Disclose your medical history, particularly if you have a personal or family history of bipolar/manic-depressive disorder, suicide attempts, seizures, low blood sodium levels, intestinal ulcers/bleeding, bleeding disorders, or glaucoma of the angle-closure type, to your healthcare provider or pharmacist before commencing this medication.

This drug may cause dizziness, which can be exacerbated by the use of alcohol or marijuana. To avoid any potential danger, do not drive, operate machinery, or engage in activities requiring mental alertness until it is safe to do so.

Elderly individuals may be more susceptible to the side effects of this drug, particularly bleeding, and may be more likely to develop hyponatremia, a type of salt imbalance, particularly if they are taking diuretics (water pills) alongside this medication.

During pregnancy, this medication should be used only when necessary, as it may harm an unborn baby. Infants born to mothers who have used this medication in the last three months of pregnancy may experience withdrawal symptoms such as feeding or breathing difficulties, seizures, muscle stiffness, or persistent crying. If you observe any of these symptoms in your newborn, inform your doctor immediately.

As untreated mental/mood conditions such as depression can have severe consequences, it is crucial not to stop taking this medication unless directed by your healthcare provider. If you are contemplating pregnancy, currently pregnant, or think you might be pregnant, it is advisable to discuss the benefits and risks of using this medication during pregnancy with your doctor.

It is unknown if this drug passes into breast milk. Consult with your doctor before breastfeeding.

Form and Strength

Trintellix is available in the following forms and strengths:

  • Trintellix film-coated tablet:

    • 5mg
    • 10mg
    • 15mg
    • 20mg


Do you feel Trintellix immediately?

Trintellix does not start working immediately. While it may take 2 weeks to start feeling the benefits of Trintellix, it can often take 4 weeks or longer to feel the full effects of the drug.

Does Trintellix have a calming effect?

Overall, it has proven to be effective at reducing anxiety and depression symptoms for people with major depressive disorder or high levels of anxiety.



Additional information

Generic name:



Film Coated Tablet


5mg, 10mg, 15mg, 20mg

Quantities Available:

28, 56, 84, 100

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Trintellix (Vortioxetine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Trintellix (Vortioxetine).