Trulance (Plecanatide) Customer Reviews


Rx Prescription Required    RxFormulation : Tablet

StrengthQuantity & PriceBuy Now
Buy Now
norton image

We don't have this generic product yet!

Sign up to get exclusive coupon discounts and be the first to be notified when we have this product available.

norton image

We are Certified


What is Trulance used for?

Trulance, with the generic name Plecanatide, is a guanylate cyclase-C (GC-C) agonist that targets the gut area. It is used to treat inflammatory bowel syndrome with constipation and chronic constipation with an unknown cause. This drug can help relieve frequent straining, long-term constipation, stomach discomfort, and bloating.

How does Trulance work? 

After absorption into the bloodstream, Trulance medication works by activating GC-C protein in the stomach. It stimulates increased secretion of intestinal fluid and boosts the food movement. As a result, this medication aids in the relief of abdominal pain, the softening of stool, and the stimulation of regular bowel movements.

Best way to use Trulance 

To begin, carefully read all drug guidelines and information. Use the drug as directed. If there is anything you don’t understand that confuses you, seek medical advice from a qualified professional. 

Trulance dosage and frequency vary among individuals according to the patient’s condition and tolerance to therapy. This medicine comes in 3 mg per tablet.

As prescribed, take this medication orally once daily. It can be taken with or without regard to food or on an empty stomach. 

Consume the whole pill with a cup of water. If you are having a hard time ingesting the tablet, crush it and sprinkle entire granules on a spoonful of applesauce or dissolve it in 30 mL of water and swallow it without chewing.           

To avoid missing a dosage, take this medication orally at the same time every day. If you ever forget to take your pill, take it as soon as you remember it. If it is already late in the afternoon, skip the missed dose and return to your regular schedule. Double dosing is discouraged. 

Because of the increased risk of developing undesired side effects, altering the dosing and frequency of this pill is not recommended. If you need to make any changes, talk to your doctor.

Trulance Side Effects 

The most common reported side effects of using this medication that usually improves over time include: 

  • Diarrhea 
  • Nausea
  • Stomach pain
  • Bloated
  • Dizziness
  • Urinary tract infection
  • Flu-like symptoms: colds, runny or stuffy nose, sore throat, headache 

Stop taking this drug as soon as possible and notify your doctor immediately if these side effects exacerbate over time and if you develop any of the following adverse reactions: 

  • Severe diarrhea 
  • Bloody or black tarry stools 
  • Signs of dehydration: confusion, fainting, increased heartbeat 

Note that this list does not include all of the potential side effects of this medication. Other unwanted outcomes are possible.


Before you start using this medication, tell your doctor everything you know about your medical history, especially if you have intestinal blockage, as this drug can exacerbate your current medical condition. 

Do not use this drug if you have an allergy to Plecanatide, metformin, or other components. When taking this medication, keep an eye out for any allergic reactions such as rashes, hives, swelling of the face and lips, throat tightness, or difficulty breathing. As soon as these signs and symptoms appear, you should seek medical help. 

Inform your doctor about your medicines and vitamins to avoid drug interactions. 

Remember to keep this medication in a cold, dry location. Keep this medication, as well as all other medications, out of the reach of children.

How much does Trulance cost? 

Given its potent effect, the price of Trulance is relatively justifiable. Purchase this medication in this online drug store for fast and easy transactions.

Frequently Asked Questions 

What is the difference between Trulance vs Linzess? 

Both medications are GC-C agonists; however, the former contains plecanatide, whereas Linzess contains linaclotide as an active ingredient. Trulance is available in 3 mg tablets, while Linzess comes in 72 mcg, 145 mcg, and 290 mcg oral capsules. In addition, this prescription drug is given with or without meals, while Linzess should be administered 30 minutes before breakfast.

Is it safe to give Trulance to young children? 

Because of the higher risk of dehydration, this drug is given to individuals above 18 years of age. Consult your healthcare practitioner about the appropriate medication for your child.

How long does it take to see the benefits of Trulance? 

It differs from person to person, depending on how your body reacts to the treatment. However, studies show that those with long-term constipation noticeably improve after one week of using this medication. Call your doctor to say if your condition worsens or if no improvement has been noted.

Is it safe to use Trulance for a longer duration? 

Yes, Trulance is generally safe for long-term use. 

Additional information

Generic name:






Quantities Available:

30, 90

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Trulance (Plecanatide). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Trulance (Plecanatide).