Vetoryl (Trilostane) Customer Reviews


Rx Prescription Required    RxFormulation : Capsule

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Trilostane is a prescribed medication utilized in the management of hyperadrenocorticism, also known as Cushing’s Disease, in dogs and cats. Hyperadrenocorticism occurs when an animal’s adrenal glands overproduce cortisol, a naturally occurring steroid produced by the body. Trilostane is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex.

Uses and Dosage

Trilostane is administered orally, in capsule form, and should be given with a meal. It is recommended to administer it in the morning if you’re using a once-daily dosing schedule.

Typically, you can expect this medication to take effect within 1 to 2 days.

Do not open, split, or divide the capsules. For dogs or puppies weighing between 3.8-10 lbs, provide one 5 mg or 10 mg capsule daily. Dogs weighing between 10-22 lbs should receive one 30 mg capsule daily. If your dog falls within the 22-44 lbs range, administer one 60 mg capsule daily. For dogs weighing 44-88 lbs, one 120 mg capsule is appropriate. Dogs between 88-132 lbs should receive one 120 mg capsule and one 60 mg capsule daily (totaling 180 mg). If your dog weighs over 132 lbs, consult your veterinarian for the correct dosage based on their weight.

Remember to wash your hands after handling the medication.

If you are pregnant or planning to become pregnant, avoid handling this medication.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • lethargy
  • vomiting
  • diarrhea
  • lack of appetite

Inform your healthcare provider immediately if you experience any serious side effects:

  • weakness
  • bloody diarrhea
  • collapse


Trilostane should not be administered to pets that have shown hypersensitivity or allergies to it.

Pregnant animals should also avoid this medication.

Caution is advised when using trilostane in pets with kidney or liver impairments, as well as in nursing animals.

The safe use of trilostane has not been evaluated in male dogs used for breeding purposes.

Form and Strength

Vetoryl is available in the following forms and strengths:

  • Vetoryl capsule:

    • 30mg


How long does it take Vetoryl to work in dogs?

Vetoryl starts working within 1-2 days. However, observable effects of the medication may take a few weeks.

How does Vetoryl work?

Vetoryl controls the adrenal glands excess production of cortisol, a hormone released into the bloodstream when a dog is stressed.



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Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Vetoryl (Trilostane). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Vetoryl (Trilostane).