Prescription Required 
Formulation : 
Description
Indications
Didanosine, when combined with other drugs, is utilized in the treatment of human immunodeficiency virus (HIV) infection.
It belongs to a group of medications known as nucleoside reverse transcriptase inhibitors (NRTIs). Its mechanism involves reducing HIV levels in the bloodstream. While it doesn’t eradicate HIV, it can lower the likelihood of acquiring acquired immunodeficiency syndrome (AIDS) and HIV-associated ailments like severe infections or cancer.
Uses and Dosage
Didanosine is available in extended-release capsules and oral solution form for oral administration. The oral solution is typically taken once or twice daily, either 30 minutes before or 2 hours after meals. Extended-release capsules are usually taken once daily on an empty stomach.
Consistency in timing is crucial, so aim to take didanosine at the same time(s) every day.
Avoid deviating from the prescribed dosage; taking more or less frequently than directed can be harmful.
For extended-release capsules, swallow them whole without splitting, chewing, or crushing. Notify your doctor if you encounter difficulty swallowing the capsules whole.
If using the oral solution, ensure thorough shaking before each use to ensure even distribution of the medication. Employ a dose-measuring spoon or cup for precise measurement, avoiding household spoons.
Remember, didanosine manages HIV infection but does not eradicate it. Consistently take the medication even if you feel well. Ceasing treatment without consulting your doctor can exacerbate your condition or make it harder to treat if doses are missed or discontinued.
Side Effects
Some side effects may occur that usually do not need medical attention:
- diarrhea
- dry eyes
- dryness of mouth
- gas
- headache
- heartburn
- loss of appetite
- nausea
- rash
- vomiting
Inform your healthcare provider immediately if you experience any serious side effects:
- abdominal pain
- fever and chills
- increased fat on the upper back, neck, breasts, and around the trunk; and loss of fat from the legs, arms, and face
- muscle aches
- blood in stools
- blood in urine
- bloody nose
- coughing blood
- cuts that don’t stop bleeding
- dark urine
- diarrhea
- loss of appetite
- nausea
- pale stools
- vomiting
- weight loss
- yellowing of the skin or whites of the eyes
- tingling, burning, or numbness and pain in the hands or feet
- vision changes
Caution
- Before initiating didanosine treatment, inform your doctor or pharmacist about any known allergies, as this product may contain inactive ingredients that could trigger allergic reactions or other complications.
- Prior to using this medication, disclose your medical history to your healthcare provider, particularly if you have a history of pancreatitis, kidney or liver issues, nerve problems like peripheral neuropathy, alcohol consumption, elevated blood triglyceride levels, gallbladder problems such as gallstones, or gout.
- Refrain from consuming alcoholic beverages as they might heighten the risk of liver problems and pancreatitis.
- Didanosine may elevate the risk of heart attacks. Have a discussion with your doctor about the potential risks and benefits of treatment, as well as strategies to mitigate your risk of heart disease. Inform your doctor if you have existing heart problems, smoke, or have other conditions that predispose you to heart disease, such as hypertension, diabetes, or elevated cholesterol levels.
- Older adults may face an increased risk of pancreatitis while using this medication.
- During pregnancy, this medication should only be used when absolutely necessary. Treatment can reduce the risk of transmitting HIV to your baby, and didanosine might be a component of that regimen. Have a thorough discussion with your doctor regarding the risks and benefits.
- It’s uncertain whether this medication passes into breast milk. Since breast milk could potentially transmit HIV, consult your doctor before breastfeeding.
Form and Strength
Videx EC is available in the following forms and strengths:
- didanosine extended-release capsule:
- 250 mg
- 400 mg
FAQ
Does Videx EC prevent me from transferring HIV to others?
No. Videx EC will help manage your infection and prevent further serious complications, but it is not a cure and doesn’t stop you from spreading HIV.
Should I take this medication with or without food?
You should take Videx EC on an empty stomach, as it seems to make the medication more effective.
Resources
- https://www.mayoclinic.org/drugs-supplements/didanosine-oral-route/description/drg-20068638
- https://www.medbroadcast.com/drug/getdrug/videx-ec
- https://www.rxlist.com/videx-ec-drug.htm
- https://www.webmd.com/drugs/2/drug-20080/videx-ec-oral/details
- https://medlineplus.gov/druginfo/meds/a691006.html
- https://www.drugs.com/pro/videx-ec.html
