Xerese (Acyclovir/Hydrocortisone) Customer Reviews


Rx Prescription Required    RxFormulation : Cream

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This medication combines two active ingredients: acyclovir and hydrocortisone. It is primarily used to treat cold sores or fever blisters caused by the herpes simplex virus. Acyclovir, an antiviral medication, works by inhibiting the growth of the virus. Hydrocortisone, a corticosteroid, aids in relieving symptoms such as itching, pain, and burning.

Uses and Dosage

To use this medication effectively, apply it at the first sign of a cold sore outbreak. Before and after application, wash your hands thoroughly with soap and water. Ensure the affected area is clean and dry before applying the medication.

Follow your doctor’s instructions and apply a thin layer of the cream on the affected area, typically 5 times a day (every 3 to 4 hours) for a duration of 5 days. Apply enough cream to cover all affected areas, but avoid rubbing the area to prevent spreading to other areas around your mouth or exacerbating the cold sore.

Refrain from using other skin products, including makeup, sunscreen, or lip balm, and avoid covering the affected area with a bandage.

To ensure the medication stays in place, refrain from bathing, showering, or swimming for at least 30 minutes after application. Do not apply this medication in the eyes or nose, inside the mouth, or on the genitals.

Remember that cold sores caused by herpes can easily spread. While acyclovir/hydrocortisone cream can help alleviate symptoms, it does not prevent the spread of herpes. Avoid sharing eating utensils, cups, razors, or towels during an outbreak. Additionally, try to refrain from touching the cold sore, including kissing, and wash your hands if you inadvertently touch it.

Consistent use of this product is essential to derive the maximum benefit. If your condition persists or worsens after 2 weeks, inform your doctor promptly.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • drying or flaking of the skin
  • burning or tingling following application
  • skin redness
  • changes in skin color
  • inflammation at the application site
  • bitter taste in your mouth after applying the medicine

Inform your healthcare provider immediately if you experience any serious side effects:

  • hives
  • difficulty breathing
  • swelling of your face, lips, tongue, or throat
  • burning, stinging, or irritation of treated skin


  • Before using this product, communicate with your doctor or pharmacist about any allergies you may have, especially if you are allergic to acyclovir or hydrocortisone, or any other components present in the medication. Inactive ingredients could potentially cause allergic reactions or other complications.
  • Discuss your medical history with your doctor or pharmacist before using this medication.
  • If you are pregnant, inform your doctor before using this medication.
  • While this product may pass into breast milk in small amounts, it is unlikely to harm a nursing infant. Consult your doctor before breastfeeding to ensure the safety of the medication for both you and your baby.

Form and Strength

Xerese is available in the following forms and strengths:

  • Xerese cream:
    • 5 / 1 %


Can Xerese only be used on my lips?

Xerese is used for cold sores on the lips or mouth. It can’t be used for any other type of infection or lesion located anywhere else on the body.

How well does Xerese work?

During clinical trials, people who used Xerese had less worsening of their cold sores and had a healing time that was 1.5 days shorter.


  1. https://www.goodrx.com/xerese/what-is
  2. https://www.mayoclinic.org/drugs-supplements/acyclovir-and-hydrocortisone-topical-application-route/description/drg-20074300
  3. https://www.rxlist.com/xerese-drug.htm
  4. https://www.webmd.com/drugs/2/drug-154490/xerese-topical/details
  5. https://www.drugs.com/xerese.html

Additional information

Generic name:






Quantities Available:

5g, 10g, 15g

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Xerese (Acyclovir/Hydrocortisone). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Xerese (Acyclovir/Hydrocortisone).