This medication is a combination of two active ingredients: dapagliflozin and metformin. It is prescribed alongside a balanced diet and exercise regimen to manage elevated blood sugar levels in individuals diagnosed with type 2 diabetes. Maintaining proper blood sugar control is crucial in preventing complications such as kidney damage, vision impairment, nerve disorders, limb amputations, and sexual function issues. The mechanism of action involves aiding the restoration of your body’s natural response to insulin, increasing the elimination of sugar by your kidneys, reducing sugar production in your liver, and limiting sugar absorption from your stomach and intestines.
Uses and Dosage
Follow your doctor’s instructions when taking this medication by mouth, typically once daily in the morning with a meal. Make sure to swallow the tablets whole and avoid crushing or chewing them, as this could lead to an excessive release of the drug all at once, elevating the risk of side effects.
The prescribed dosage hinges on your medical condition, response to treatment, and any other medications you may be using. Inform your doctor and pharmacist about all the products you are currently using, encompassing prescription drugs, over-the-counter medications, and herbal supplements.
To mitigate the chances of experiencing side effects like diarrhea, nausea, and vomiting, your doctor might recommend initiating treatment with a lower dose and gradually increasing it. Adhere closely to your doctor’s instructions.
Consistency in taking this medication is key to reaping its full benefits. To help you remember, establish a routine of taking it at the same time every day.
Keep your doctor informed if your condition does not show signs of improvement or deteriorates, such as experiencing excessively high or low blood sugar levels.
Some side effects may occur that usually do not need medical attention:
- muscle aches
- sore throat
- stuffy or runny nose
- back pain
- body aches or pain
- difficulty having a bowel movement
- tender, swollen glands in the neck
- voice changes
Inform your healthcare provider immediately if you experience any serious side effects:
- bladder pain
- bloody or cloudy urine
- change in the color, amount, or odor of vaginal discharge
- difficult, burning, or painful urination
- frequent urge to urinate
- lower back or side pain
Before commencing this medication, please inform your doctor or pharmacist if you are allergic to dapagliflozin or metformin or if you have any other allergies. This product may contain inactive ingredients capable of causing allergic reactions or other complications.
Share your medical history with your doctor or pharmacist before using this medication, particularly if you have a history of breathing problems, kidney disease, liver disease, alcohol use or abuse, yeast infections in the vagina or penis, dehydration, or blood problems.
Extreme low or high blood sugar levels may lead to blurred vision, dizziness, or drowsiness. Do not engage in activities that require alertness or clear vision, such as driving or operating machinery, until you are certain you can do so safely.
Refrain from excessive alcohol consumption while taking this medication, as it can heighten your risk of developing lactic acidosis, low blood sugar, and elevated ketone levels.
Dehydration may occur due to various factors, including high fever, the use of diuretics (“water pills” like hydrochlorothiazide), profuse sweating, diarrhea, or vomiting, and it can increase your risk of lactic acidosis. If you experience prolonged diarrhea or vomiting, discontinue the medication and promptly inform your doctor. Unless otherwise directed by your doctor, ensure you maintain adequate fluid intake to prevent dehydration.
Stressful situations, such as fever, infection, injury, or surgery, can make it more challenging to control your blood sugar levels. If you are eating less or unable to eat due to illness or other conditions, this may result in elevated ketone levels while taking this medication. Consult your doctor, as this may necessitate modifications to your treatment plan, medications, or blood sugar and ketone testing.
Older adults may be more susceptible to the side effects of this drug, including low blood sugar, dehydration, lactic acidosis, kidney problems, and low blood pressure.
During pregnancy, this medication should be employed only when absolutely essential. Discuss the risks and benefits with your doctor.
Pregnancy can induce or exacerbate diabetes, so it is important to collaborate with your doctor on a blood sugar management plan during pregnancy. Your diabetes treatment may require adjustments during this period, such as dietary changes and alterations to medications, including insulin.
Metformin can influence the menstrual cycle by promoting ovulation and increasing the likelihood of pregnancy. Seek advice from your doctor or pharmacist regarding the use of reliable birth control methods while taking this medication.
While metformin passes into breast milk in small amounts, it remains uncertain whether dapagliflozin does the same. Consult your doctor before breastfeeding.
Form and Strength
Xigduo XR is available in the following forms and strengths:
Xigduo XR extended-release tablet:
Can Xigduo XR help with weight loss?
Although Xigduo XR is not a weight loss or blood pressure medication, AstraZeneca claims that it may help people lose weight — on average 3%.
Can I use insulin if I’m taking Xigduo XR?
It’s possible that your provider might prescribe Xigduo XR and insulin for you at the same time.