Zonegran (Zonisamide) Customer Reviews


Rx Prescription Required    RxFormulation : Capsule

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Generic alternative for Zonegran


Rx Prescription Required    RxFormulation : Capsule

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Zonisamide is utilized in conjunction with other medications to manage specific types of seizures. Categorized as an anticonvulsant medication, zonisamide functions by mitigating aberrant electrical activity within the brain.

Uses and Dosage

Zonisamide is administered orally in the form of capsules. It is typically taken once or twice a day, with or without food.

To ensure consistency, take zonisamide at approximately the same time(s) every day. Take zonisamide precisely as directed, and do not exceed or diminish the dosage or frequency without the guidance of your physician.

The capsules should be swallowed whole, without splitting, chewing, or crushing them.

Your doctor may initiate your treatment with a low dosage of zonisamide and gradually increase it, not exceeding once every two weeks.

Zonisamide may regulate your condition, but it does not cure it. It may take up to two weeks or longer before the full benefits of zonisamide become apparent. Continue taking zonisamide, even if you feel better.

Do not discontinue the medication without consulting your doctor, even if you encounter side effects such as abnormal alterations in mood or behavior. Abruptly ceasing zonisamide may worsen your seizures, and your physician will likely reduce your dose gradually.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • nausea
  • vomiting
  • weight loss
  • changes in taste
  • diarrhea
  • constipation
  • heartburn
  • dry mouth
  • headache
  • dizziness
  • confusion
  • irritability
  • difficulty falling asleep or staying asleep
  • difficulty with memory
  • pain, burning, numbness, or tingling in the hands or feet
  • uncontrollable eye movements
  • double vision

Inform your healthcare provider immediately if you experience any serious side effects:

  • rash
  • blistering or peeling of skin
  • worsening or longer-lasting seizures
  • sudden back pain
  • stomach pain
  • pain when urinating
  • bloody or dark urine
  • fever, sore throat, chills, cough, and other signs of infection
  • sores in mouth
  • easy bruising
  • difficulty thinking of words or trouble speaking
  • difficulty thinking or concentrating
  • lack of coordination
  • difficulty walking
  • severe weakness
  • severe muscle pain
  • extreme tiredness
  • loss of appetite
  • fast, shallow breathing
  • irregular heartbeat
  • loss of consciousness


Prior to commencing zonisamide, inform your healthcare provider or pharmacist if you have an allergy to it, or if you are hypersensitive to other substances. This product may comprise inactive components that can elicit allergic reactions or other medical complications.

Before utilizing this medication, relay your medical history to your physician or pharmacist, particularly if you have a history of liver disease, kidney disease, lung/breathing problems, long-term diarrhea, metabolic imbalance (metabolic acidosis), adherence to a specialized diet (ketogenic diet), or mental/mood problems.

This medication may cause dizziness or drowsiness. Alcohol or marijuana may exacerbate these symptoms. Refrain from operating machinery, driving, or engaging in activities that necessitate alertness until you can do so safely.

This medication may cause reduced sweating, increasing the likelihood of heat stroke. Avoid activities that may cause overheating, such as strenuous labor or exercise in hot weather, or using hot tubs. During warm weather, drink ample fluids and dress appropriately. If you overheat, promptly seek a cool environment and rest. Seek medical attention immediately if you experience an unrelenting fever, alterations in mood/mental state, headache, or dizziness.

Older adults may be more susceptible to the side effects of this medication, particularly dizziness, lightheadedness, or loss of coordination. These side effects can raise the risk of falling.

Children may be more vulnerable to the side effects of this medication, such as decreased sweating, heat stroke, or metabolic imbalance.

During pregnancy, this medication should only be used when absolutely necessary. It may harm an unborn baby. Inquire about dependable birth control methods while taking this medication and for one month following the final dose.

Since untreated seizures can pose a serious threat to both a pregnant woman and her unborn baby, do not discontinue this medication without your physician’s advice. If you plan to become pregnant, are currently pregnant, or suspect you may be pregnant, discuss the potential benefits and risks of utilizing this medication with your doctor.

This medication is excreted into breast milk. Consult your physician before nursing your infant.

Form and Strength

Zonegran is available in the following forms and strengths:

  • zonisamide capsule:

    • 25mg
    • 50mg
    • 100mg


What does Zonegran do to the brain?

It’s not exactly clear how Zonegran works, but it’s thought to block the nerves in your brain from sending electrical signals that cause seizures.

How long does it take to adjust to Zonegran?

It may take 2 weeks or longer before you feel the full benefit of Zonegran.



Additional information

Generic name:





25mg, 50mg, 100mg

Quantities Available:

56, 100, 112

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Zonegran (Zonisamide). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Zonegran (Zonisamide).