Iopidine Eyedrops (Apraclonidine hydrochloride)

Description

Indications

Apraclonidine 0.5% eye drops are employed for the short-term treatment of glaucoma, a condition characterized by increased pressure in the eye that can cause damage to the optic nerve and lead to vision loss. This medication is specifically used in individuals who are already taking other medications for glaucoma but still experience elevated eye pressure.

Apraclonidine belongs to a class of medications known as alpha-2-adrenergic agonists. Their primary mechanism of action involves lowering the pressure in the eye by reducing the production of fluid within the eye. This can help manage glaucoma and prevent complications associated with increased eye pressure.

Uses and Dosage

Apraclonidine is available as a 0.5% solution and a 1% solution for instillation in the eye. The 0.5% solution is typically applied to the affected eye(s) three times a day. The 1% solution, on the other hand, is usually applied to the eye undergoing treatment one hour before laser eye surgery and immediately after the procedure. If you are using apraclonidine eye drops regularly, it’s recommended to use them at approximately the same times each day.

Use apraclonidine eye drops precisely as directed—do not exceed or reduce the dosage or use them more frequently than prescribed by your doctor.

Apraclonidine eye drops are specifically intended for use in the eye, and they should not be swallowed.

It’s important to note that the effectiveness of apraclonidine 0.5% eye drops may decrease after a certain period, typically less than one month. Your doctor will monitor you regularly during the use of apraclonidine 0.5% eye drops to assess their continued efficacy.

While apraclonidine 0.5% eye drops help control glaucoma for a short duration, they do not cure the condition. Even if you feel well, continue using apraclonidine 0.5% eye drops as prescribed. Do not discontinue their use without consulting your doctor.

To administer the eye drops, the following steps should be followed:

1. Thoroughly wash hands with soap and water.
2. Do not allow the dropper tip to touch the eye or any other surface, and ensure that it is kept clean.
3. Tilt the head back and pull down the lower lid of the eye using the index finger to form a pocket.
4. Hold the dropper as close to the eye as possible without making contact, and brace the remaining fingers against the face.
5. Squeeze the dropper gently to instill a single drop in the pocket created by the lower eyelid while looking upwards.
6. Remove the index finger from the lower eyelid and keep the eye closed for 2-3 minutes while tilting the head down.
7. Apply gentle pressure to the tear duct using a finger.
8. Use a tissue to wipe off any excess liquid from the face.
9. Wash hands to remove any residual medication.

Side Effects

Some side effects may occur that usually do not need medical attention:

• red, swollen, itchy, or teary eyes
• eye discomfort
• feeling that something is in the eye
• irregular, slow, or pounding heartbeat
• blurred vision
• pale eyes
• dry eyes
• widened pupils (dark circles in the center of the eyes)
• raised eyelids
• lack of usual coordination
• lack of energy
• sleepiness
• difficulty falling asleep or staying asleep
• unusual dreams
• dizziness
• headache

Inform your healthcare provider immediately if you experience any serious side effects:

• fainting
• swelling of the face, eyes, arms, hands, feet, ankles, or lower legs
• shortness of breath

Caution

• Before using apraclonidine, inform your doctor or pharmacist about any allergies you may have, including allergies to apraclonidine or clonidine, or any other substances. This product may contain inactive ingredients that could potentially cause allergic reactions or other complications.
• Share your medical history with your doctor or pharmacist before using this medication, especially if you have a history of blood vessel disease, high blood pressure, recent heart attack, kidney disease, or mental/mood disorders.
• After applying this drug, your vision may become temporarily blurred or unstable. In some cases, this medication may make you dizzy or drowsy. The consumption of alcohol or marijuana can intensify these effects. Avoid activities that require alertness or clear vision, such as driving or using machinery, until you can do so safely.
• During pregnancy, use this medication only when deemed essential. Discuss the potential risks and benefits with your doctor.
• The passage of this medication into breast milk is not well understood. Consult your doctor before breastfeeding to make an informed decision based on your specific situation.

Form and Strength

Iopidine Eyedrops is available in the following forms and strengths:

• Iopidine Eyedrops drops:
  • 0.50 %

FAQ

How long does it take Iopidine Eyedrops to work?

The onset of action of Iopidine Eyedrops can usually be noted within one hour and the maximum intraocular pressure reduction usually occurs three to five hours after application of a single dose.

Can I drink alcohol with Iopidine Eyedrops?

You should avoid or limit the use of alcohol while being treated with Iopidine Eyedrops.

Resources

1. https://www.medsafe.govt.nz/consumers/cmi/i/iopidine.pdf
2. https://www.mayoclinic.org/drugs-supplements/apraclonidine-ophthalmic-route/description/drg-20062024
3. https://www.healthlinkbc.ca/medications/apraclonidine-solution-05-ophthalmic
4. https://medlineplus.gov/druginfo/meds/a608005.html
5. https://www.webmd.com/drugs/2/drug-4493-8030/iopidine-ophthalmic-eye/apraclonidine-solution-0-5-ophthalmic/details