Etiricoxib, classified as a non-steroidal anti-inflammatory drug (NSAID), exhibits analgesic and anti-inflammatory properties. It effectively mitigates pain and reduces swelling associated with conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and, on occasion, gout during short-term treatment periods.
The mechanism of action of etoricoxib involves the inhibition of cyclo-oxygenase-2 (COX-2), a naturally occurring enzyme in the body. This particular enzyme plays a crucial role in the synthesis of prostaglandins, a group of chemicals involved in the body’s inflammatory response. By impeding the activity of COX-2 enzymes, the production of prostaglandins is reduced, leading to alleviation of pain and inflammation.
Uses and Dosage
Adhere to the prescribed dosage of etoricoxib provided by your doctor, taking it once daily. Etoricoxib is available in four different tablet strengths: 30 mg, 60 mg, 90 mg, and 120 mg. The appropriate strength will be determined based on your specific medical condition.
Typically, individuals with osteoarthritis are prescribed a once-daily dose of 30 mg, with the option to increase to 60 mg if necessary. For those with rheumatoid arthritis or ankylosing spondylitis, the usual dose is 60 mg once daily, but it may be raised to 90 mg if required. In the case of gout, a short-term course of 120 mg strength tablets will be prescribed for daily use, lasting up to eight days.
When taking the tablet, swallow it with water. It can be taken with or without food; however, taking it without food may result in faster absorption.
Take your daily doses at the same time each day to establish a routine and facilitate better adherence.
If you happen to forget taking the tablet at the usual time, take it as soon as you remember. If you only recall the next day, omit the missed dose from the previous day and resume with the regular dose. Do not double the dose to compensate for a missed one.
Some side effects may occur that usually do not need medical attention:
- heartburn, uncomfortable feeling in the stomach
- mouth ulcers
- changes in taste
- swelling of the legs, ankles or feet
- high/increase in blood pressure
- headache, dizziness
- unusual tiredness or weakness
- difficulty sleeping
- signs of urinary tract infection, including painful burning when passing urine
- high levels of potassium in your blood
- signs of an infection of the breathing passages, including runny nose, sore throat, cough
- feeling anxious
- seeing, feeling or hearing things that are not there
- blurred vision
Inform your healthcare provider immediately if you experience any serious side effects:
- skin rash or itchiness
- pinkish, itchy swellings on the skin
- redness of the skin
- severe stomach pain
- passing little or no urine
- yellowing of the skin and/or eyes, also called jaundice
- a feeling of pain, tightness, pressure or heaviness in the chest (angina)
- increased tendency to bleed/bruise, or tendency to bleed for a longer period of time – these may be symptoms of reduced platelets in your body
- severe pain and swelling following a dental extraction, “dry socket”
- gout pain
Arcoxia should not be taken in certain situations. Firstly, if you have an allergy to Arcoxia or any of its listed ingredients. Additionally, if you have previously experienced asthma, hives, runny nose, or other allergic reactions due to aspirin or other NSAIDs, Arcoxia should be avoided. If you have a history of heart failure, heart attack, angina, peripheral arterial disease, stroke, or mini-stroke, or if you have recently undergone major surgery on your heart or arteries, Arcoxia is contraindicated.
In cases where your high blood pressure is not effectively controlled, it is necessary to consult your doctor or nurse to determine if Arcoxia is appropriate for you.
Serious liver disease, current stomach ulcer or bleeding in the stomach or intestines, and serious kidney disease are all conditions that preclude the use of Arcoxia.
Do not take Arcoxia if the packaging is torn or shows signs of tampering, or if the expiration date on the pack has passed. The medicine may not work properly if taken after the expiry date.
Prior to initiating treatment, have a discussion with your doctor about the signs and symptoms of serious cardiovascular risks and the appropriate steps to take if they occur.
Inform your doctor if you are pregnant or planning to become pregnant. Arcoxia should not be used from the 20th week of pregnancy onwards due to potential harm to the fetus. If the need arises to consider using Arcoxia during pregnancy, your doctor will discuss the benefits and risks with you.
If you are breastfeeding or plan to breastfeed, discuss with your doctor as it is uncertain whether Arcoxia passes into breast milk. Your doctor will provide guidance on whether you should discontinue breastfeeding or avoid taking Arcoxia.
Form and Strength
Arcoxia is available in the following forms and strengths:
How quickly does Arcoxia work?
Pain relief was observed as early as four hours after initiation of treatment.
Does Arcoxia make you sleepy?
Dizziness and sleepiness have been reported in some patients taking Arcoxia.