Arthrotec (Diclofenac/Misoprostal) Customer Reviews


Rx Prescription Required    RxFormulation : Tablet

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This combination product contains two medications used to treat rheumatoid arthritis and osteoarthritis. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) utilized for the alleviation of pain, inflammation, and joint stiffness associated with arthritis. To mitigate diclofenac’s potential stomach irritations, misoprostol is employed to safeguard the gastrointestinal tract. This combined medication is specifically employed for managing arthritis in individuals deemed at high risk for developing stomach or intestinal ulcers, as well as complications stemming from such ulcers, including bleeding.

Uses and Dosage

Administer this medication orally, accompanied by a full glass of water (8 ounces/240 milliliters), unless otherwise instructed by your physician. Refrain from reclining for a minimum of 10 minutes after consuming the medication.

Ingest the tablets whole, without crushing, chewing, or dissolving them, as doing so can heighten the likelihood of experiencing adverse effects. Avoid using broken tablets.

To prevent stomach discomfort and reduce the risk of diarrhea, take this medication with food. Refrain from using antacids containing magnesium concurrently with this medication, as they may exacerbate diarrhea. If an antacid is necessary, consult your healthcare provider or pharmacist for guidance in selecting an appropriate product.

The dosage of this medication is contingent upon your medical condition, response to treatment, and concurrent medication usage.

To minimize the potential for stomach bleeding and other side effects, consume this medication at the lowest effective dose for the shortest duration possible. Avoid escalating the dosage or using the drug more frequently or for a longer duration than prescribed. For chronic conditions like arthritis, adhere to the prescribed regimen of this medication.

Consistently utilize this medication to derive maximum benefit. Establish a routine by taking it at the same time each day to aid in remembering. It may take up to 2 weeks of regular usage before experiencing the medication’s full efficacy.

Notify your doctor if your condition fails to improve or worsens.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • diarrhea
  • constipation
  • gas or bloating
  • headache
  • dizziness
  • ringing in the ears

Inform your healthcare provider immediately if you experience any serious side effects:

  • unexplained weight gain
  • shortness of breath or difficulty breathing
  • swelling of the abdomen, feet, ankles, or lower legs
  • excessive tiredness
  • lack of energy
  • nausea
  • loss of appetite
  • itching
  • pain in the upper right part of the stomach
  • yellowing of the skin or eyes
  • flu-like symptoms
  • fever
  • blisters
  • rash
  • hives
  • swelling of the eyes, face, tongue, lips, throat, arms, or hands
  • difficulty breathing or swallowing
  • hoarseness
  • pale skin
  • fast heartbeat
  • cloudy, discolored, or bloody urine
  • back pain
  • difficult or painful urination


Prior to initiating this medication, inform your healthcare provider or pharmacist about any known allergies to diclofenac, misoprostol, aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, or celecoxib, or any other substances. This product may contain inactive ingredients that could provoke allergic reactions or other complications.

Before using this medication, disclose your medical history to your doctor or pharmacist, particularly if you have a history of liver disease, gastrointestinal issues, heart disease, high blood pressure, stroke, swelling (edema) or fluid retention, blood disorders, bleeding or clotting disorders, asthma aggravated by aspirin or other NSAIDs, or nasal polyps.

Kidney problems can occasionally occur with the use of NSAID medications, including diclofenac. The likelihood of experiencing such problems is heightened if you are dehydrated, have heart failure or kidney disease, are an older adult, or are taking certain medications. Adequate fluid intake as directed by your doctor is crucial to prevent dehydration. Notify your doctor promptly if there is a change in your urine output.

This medication may induce dizziness or drowsiness. The consumption of alcohol or marijuana can intensify these effects. Refrain from driving, operating machinery, or engaging in activities requiring alertness until you can safely do so.

Diclofenac has the potential to cause stomach bleeding. Regular alcohol consumption and tobacco use, especially in combination with this medication, may heighten the risk of stomach bleeding. Limit alcohol intake and cease smoking.

This medication may increase sensitivity to sunlight. Limit sun exposure, avoid tanning booths and sunlamps, and utilize sunscreen and protective clothing when outdoors. Promptly inform your doctor if you experience sunburn or develop skin blisters or redness.

Older adults may face an elevated risk of stomach or intestinal bleeding, kidney problems, heart attack, and stroke while using this medication.

This medication must not be used during pregnancy as it may pose harm to both the mother and unborn baby. Reliable methods of contraception should be employed to prevent pregnancy while taking this medication and for at least one month or one complete menstrual cycle after treatment cessation. If you become pregnant or suspect you may be pregnant, notify your doctor without delay.

Although this medication passes into breast milk, it is unlikely to cause harm to a nursing infant. Consult your doctor before breastfeeding.

Form and Strength

Arthrotec is available in the following forms and strengths:

  • Arthrotec tablet:

    • 50mg/200mcg
    • 75mg/200mcg


Is Arthrotec a painkiller?

The diclofenac component of Arthrotec helps reduce pain along with swelling and joint stiffness that’s associated with arthritis.

Does Arthrotec make you tired?

Drowsiness is a possible side effect of this medication.



Additional information

Generic name:





50mg/200mcg, 75mg/200mcg

Quantities Available:


Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Arthrotec (Diclofenac/Misoprostal). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Arthrotec (Diclofenac/Misoprostal).