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Formulation : 
Description
Indications
Colchicine serves as a preventive measure against gout attacks in adult patients. It is also used as a means to alleviate the pain associated with gout attacks when they occur. Colchicine is additionally utilized in the treatment of familial Mediterranean fever (FMF), an innate condition characterized by intermittent episodes of fever, abdominal, pulmonary, and joint pain and swelling, in both adult and pediatric patients aged four and above. As an anti-gout agent, colchicine functions by inhibiting the natural processes responsible for the manifestation of swelling and other symptoms associated with gout and FMF.
Uses and Dosage
Colchicine is available in tablet form and as a solution for oral administration, with or without food. The dosing regimen for colchicine varies depending on its purpose. When used for the prevention of gout attacks or the treatment of FMF, it is typically taken once or twice daily.
When colchicine is used specifically to alleviate the pain of a gout attack, a single dose is usually taken at the initial onset of pain, followed by a smaller dose one hour later. If relief is not experienced or if another attack occurs within several days after treatment, consult your doctor before taking additional doses of the medication.
Take colchicine exactly as directed, without altering the dosage or frequency unless advised by your doctor.
To ensure accurate measurement of the liquid dosage, utilize an oral syringe, a specialized measuring device, rather than a household spoon.
For individuals taking colchicine to treat FMF, the initial dosage may be low and gradually increased by your doctor. Your doctor may also adjust the dosage if you experience any side effects.
If you are using colchicine to prevent gout attacks and you encounter a gout attack during your treatment, promptly contact your doctor. Your doctor may instruct you to take an additional dose of colchicine, followed by a smaller dose after one hour. If extra doses of colchicine are taken to manage a gout attack, refrain from taking the next scheduled dose until at least 12 hours have passed since the extra doses were administered.
Colchicine can only prevent gout attacks and control FMF as long as you continue to take the medication. Even if you feel well, maintain your colchicine regimen and avoid discontinuing its use without consulting your doctor.
Side Effects
Some side effects may occur that usually do not need medical attention:
- nausea
- vomiting
- diarrhea
- stomach cramps or pain
Inform your healthcare provider immediately if you experience any serious side effects:
- muscle pain or weakness
- numbness or tingling in the fingers or toes
- unusual bruising or bleeding
- sore throat, fever, chills, and other signs of infection
- weakness or tiredness
- paleness or grayness of the lips, tongue, or palms
Caution
Prior to initiating this medication, inform your doctor or pharmacist about any known allergies you may have, including allergies to the medication itself or other substances. This product may contain inactive ingredients that can potentially trigger allergic reactions or other complications.
Before commencing the use of this medication, disclose your medical history, particularly if you have kidney problems or liver problems such as cirrhosis, to your doctor or pharmacist.
Consuming alcohol while taking this medication can diminish its effectiveness. Limit alcohol intake during the course of treatment.
This medication may impact the absorption of certain foods and nutrients, such as vitamin B12, in your body.
Elderly individuals may be more susceptible to the side effects of this medication, particularly experiencing muscle weakness/pain and numbness/tingling in the fingers or toes.
Colchicine has the potential to reduce sperm production, which can affect male fertility.
During pregnancy, this medication should only be used if absolutely necessary. Discuss the potential risks and benefits with your doctor.
This medication passes into breast milk. Consult your doctor before breastfeeding. Your doctor may suggest separating the time(s) you take the medication from the breastfeeding sessions.
Form and Strength
Colcrys is available in the following forms and strengths:
-
colchicine tablet:
- 0.5mg
- 0.6mg
FAQ
How quickly does Colcrys work?
Colcrys starts to work after around 30 minutes to 2 hours, but it may take a day or two for your pain to start to get better.
Does Colcrys lower uric acid?
Colcrys lowers the ability of urate crystals to cause inflammation. It doesn’t lower uric acid levels in your blood, though.
Resources
- https://www.nhs.uk/medicines/colchicine/about-colchicine/#:~:text=Key%20facts,more%20can%20be%20very%20serious
- https://medlineplus.gov/druginfo/meds/a682711.html
- https://www.webmd.com/drugs/2/drug-152819/colcrys-oral/details
- https://www.mayoclinic.org/drugs-supplements/colchicine-oral-route/description/drg-20067653
- https://www.drugs.com/colcrys.html
