Prescription Required 
Formulation : 
Description
Indications
This medication is prescribed for the alleviation of knee pain in individuals suffering from joint inflammation, specifically osteoarthritis. It is usually administered to patients who have exhibited an inadequate response to alternative therapeutic approaches, such as acetaminophen, exercise regimens, or physical therapy. Hyaluronate, also known as hyaluronan, bears a resemblance to a naturally occurring substance within the joints. Its mechanism of action involves serving as a lubricating agent and shock absorber within the joint, facilitating smoother knee movement and diminishing discomfort.
Uses and Dosage
This medication is administered via injection into the affected joint under the supervision of a healthcare professional. The administration follows your doctor’s specific guidelines, typically on a once-weekly basis.
The dosage is determined based on your medical condition and your response to the treatment. In some cases, it may be necessary to remove excess fluid from the joint prior to injecting the medication.
Skin disinfectants containing ammonium salts, such as benzalkonium chloride, should not be employed for preparing the injection site. Hyaluronate must never be injected into a vein or artery, as doing so may result in an increased risk of adverse effects.
Following the administration of hyaluronate, abstain from activities that place undue stress on the treated knee, such as jogging, tennis, heavy lifting, or standing for extended periods exceeding an hour, for a duration of 48 hours.
Anticipate some initial post-injection pain and swelling in the knee. Should these symptoms persist or worsen, promptly consult your doctor.
Maintaining the prescribed injection schedule is of utmost importance, as it may take up to three injections before the full therapeutic benefits of this medication become evident.
Keep your doctor informed if your condition persists or deteriorates over time.
Side Effects
Some side effects may occur that usually do not need medical attention:
- mild pain, redness, heat, or swelling around the area of injection
Inform your healthcare provider immediately if you experience any serious side effects:
- burning, prickling, or tingling sensations in the hands or feet
- continued pain, swelling, redness of the affected joint with or without a fever
- dizziness
- fever or chills
- flushing or swelling of the face
- headache
- muscle cramps
- nausea
- swelling of the hands, feet, or ankles
- tiredness
Caution
Prior to initiating treatment with hyaluronate, communicate with your doctor or pharmacist regarding any known allergies you may have. This includes potential hypersensitivity to hyaluronate itself or any other allergens. For certain brands, apprise your healthcare provider or pharmacist if you have allergies to avian proteins, feathers, or egg-derived products. Some formulations of this product may incorporate inactive constituents, such as latex present in the rubber syringe cap of select brands, which have the potential to induce allergic reactions or other adverse responses.
Before commencing the use of this medication, furnish your doctor or pharmacist with a comprehensive overview of your medical history, with specific emphasis on any instances of knee joint infections, skin infections or issues in the vicinity of the intended injection site, as well as any preexisting circulatory problems in the lower extremities.
During pregnancy, the administration of this medication should be contemplated only when it is essential. Engage in a thorough discussion with your doctor concerning the associated risks and benefits.
The extent to which this drug may pass into breast milk remains undetermined. Seek counsel from your doctor before embarking on breastfeeding while undergoing treatment with this medication.
Form and Strength
Synvisc One is available in the following forms and strengths:
- Synvisc One (form)
- hylan GF 20 (form)
FAQ
How long does it take for Synvisc One to take effect?
Although everyone responds differently, most patients feel the greatest relief 8 to 12 weeks after the first injection.
How long after a knee injection can I exercise?
You can resume normal activities but avoid anything strenuous that puts excess strain on the joint for 48 hours.
Resources
- https://patient.uwhealth.org/healthfacts/8207
- https://www.mayoclinic.org/drugs-supplements/hyaluronic-acid-injection-route/precautions/drg-20074557#:~:text=Do%20not%20strain%20your%20knee,after%20receiving%20hyaluronic%20acid%20injection
- https://www.medbroadcast.com/drug/getdrug/synvisc-one
- https://www.webmd.com/drugs/2/drug-151941/synvisc-one-intra-articular/details
- https://www.everydayhealth.com/drugs/synvisc-one
- https://www.drugs.com/synvisc-one.html
