Budesonide-glycopyrrolate-formoterol is a medication combination that is utilized to alleviate the symptoms of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
Budesonide is classified as a corticosteroid and operates by decreasing inflammation in the lungs, as well as reducing swelling and irritation in the small air passages within the lungs. This results in the maintenance of open airways and improvement in breathing.
Glycopyrrolate belongs to the category of long-acting muscarinic antagonists (LAMAs), while formoterol is a long-acting beta2-agonist (LABA). These two medications operate in different ways to open up the airways, thereby facilitating easier breathing.
Uses and Dosage
The recommended dosage for budesonide-glycopyrrolate-formoterol is two inhalations taken twice daily. For optimal benefits and to assist with remembering to use the inhaler, use it at the same time each day.
Have your doctor or pharmacist explain how to use the inhaler and to carefully read the instructions before using it. Should you have any questions regarding the usage of the inhaler, consult your healthcare professional.
After inhaling the medication dose, rinse your mouth with water and spit it out to decrease the possibility of developing thrush.
Several factors, including body weight, other medical conditions, and other medications, can influence the required dosage of medication for an individual. Therefore, if your physician prescribes a different dosage from the ones listed, do not alter your medication usage without consulting your doctor.
Take this medication precisely as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular dosing schedule. In the event that it is almost time for the subsequent dose, skip the missed one and continue with your regular schedule. Avoid taking a double dose to compensate for the missed one.
Ensure to keep the inhaler in its sealed foil pouch until it is ready for use. Store the medication at room temperature, keep it protected from light and moisture, and away from the reach of children.
Some side effects may occur that usually do not need medical attention:
- back pain
- muscle spasms
- throat irritation
Inform your healthcare provider immediately if you experience any serious side effects:
- bladder pain
- bloody or cloudy urine
- blurred vision
- chest pain or tightness
- darkening of the skin
- decrease in urine volume and frequency of urination
- difficult, burning, or painful urination
- difficulty breathing
- dry mouth
- fast, pounding, or irregular heartbeat or pulse
- flushed, dry skin
- fruit-like breath odor
- general feeling of discomfort or illness
- hives, itching, skin rash
- increased hunger
- increased thirst
- increased urination
- joint pain, stiffness, or swelling
- loss of appetite
- lower back or side pain
- mental depression
- muscle aches and pains
- noisy breathing
- pain or tenderness around the eyes and cheekbones
- redness of the skin
- sore mouth, throat, or tongue
- stomach pain
- stuffy or runny nose
- swelling of the eyelids, face, lips, hands, or feet
- trouble sleeping
- trouble swallowing
- unexplained weight loss
- unusual tiredness or weakness
- white patches in the mouth or on the tongue
Prior to using this product, inform your doctor or pharmacist of any known allergies to budesonide, glycopyrrolate, formoterol, or arformoterol, as well as any other allergies that may exist. Inactive ingredients contained in the product may also cause allergic reactions or other issues.
Disclose your medical history, particularly any current or past infections such as tuberculosis or herpes, heart problems like irregular heartbeat or chest pain, high blood pressure, seizures, bone loss, eye problems such as cataracts or glaucoma, overactive thyroid, diabetes, difficulty in urinating due to an enlarged prostate, or liver disease.
This product may cause QT prolongation, which affects heart rhythm. In rare cases, QT prolongation may lead to serious, life-threatening symptoms like fast or irregular heartbeat, severe dizziness, or fainting that require immediate medical attention.
The medication may also mask signs of infection or increase the risk of infections. Avoid contact with individuals who have infections that can spread, such as chickenpox, measles, or flu.
If you have switched from a corticosteroid taken orally to this inhaler within the last 12 months or have been using this product in higher-than-usual doses for an extended period, it may be more difficult for your body to respond to physical stress. Inform your doctor or dentist before having surgery, emergency treatment, or if you get a serious illness/injury.
This medication may temporarily slow down the growth of children if used for a prolonged period. Poorly controlled asthma can also cause slow growth. Have your child’s height checked regularly by a doctor.
Older adults may be more susceptible to the drug’s side effects, especially QT prolongation.
During pregnancy, use this medication only if it is clearly necessary. Discuss the benefits and risks with your doctor.
Budesonide passes into breast milk. It is unknown if glycopyrrolate or formoterol also passes into breast milk. Please consult your doctor before breast-feeding.
Form and Strength
Breztri Aerosphere is available in the following forms and strengths:
Breztri Aerosphere aerosol inhaler:
Is Breztri Aerosphere inhaler a steroid?
Breztri Aerosphere contains budesonide, which is an inhaled corticosteroid (or steroid).
Does Breztri Aerosphere improve lung function?
Breztri Aerosphere works to make it easier for you to breathe. It does this by keeping your airways open and reducing inflammation (swelling) in your lungs.