Delestrogen (Estradiol) Customer Reviews


Rx Prescription Required    RxFormulation : Vial

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The estradiol cypionate and estradiol valerate formulations of estrogen injection are prescribed for the management of hot flushes and/or symptoms of vaginal dryness, itching, and burning in women undergoing menopause. For women seeking treatment solely for vaginal dryness, itching, or burning, alternative therapeutic options should be considered. The estradiol valerate form of estrogen injection is occasionally employed for alleviating symptoms associated with specific forms of prostate cancer. Estrogen injection belongs to a class of pharmaceuticals known as hormones, functioning by replenishing the natural production of estrogen in the body.

Uses and Dosage

The long-acting estrogen injections, specifically estradiol cypionate and estradiol valerate, are administered in liquid form via intramuscular injection. These medications are typically administered by a healthcare professional at intervals of approximately 3 to 4 weeks. In cases where estradiol valerate is utilized for the treatment of prostate cancer symptoms, healthcare professionals generally administer the injection at intervals of 1 to 2 weeks.

On the other hand, the estrogen injection in the form of conjugated estrogens is provided as a powder, which is mixed with sterile water and then injected into a muscle or vein. This method of administration is typically carried out by a healthcare professional as a single dose. If necessary to control vaginal bleeding, a second dose may be administered 6 to 12 hours after the initial dose.

For individuals utilizing estrogen injection to alleviate hot flushes, it is expected that symptom improvement will occur within 1 to 5 days following the injection. If no improvement is observed during this timeframe, inform your doctor.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • breast pain or tenderness
  • upset stomach
  • vomiting
  • weight gain or loss
  • dizziness
  • nervousness
  • depression
  • irritability
  • changes in sexual desire
  • hair loss
  • unwanted hair growth
  • spotty darkening of the skin on the face
  • difficulty wearing contact lenses
  • leg cramps
  • swelling, redness, burning, itching, or irritation of the vagina
  • vaginal discharge

Inform your healthcare provider immediately if you experience any serious side effects:

  • bulging eyes
  • pain, swelling, or tenderness in the stomach
  • loss of appetite
  • weakness
  • yellowing of the skin or eyes
  • joint pain
  • movements that are difficult to control
  • rash or blisters
  • hives
  • itching
  • swelling of the eyes, face, tongue, throat, hands, arms, feet, ankles, or lower legs
  • hoarseness
  • difficulty breathing or swallowing


Prior to initiating treatment with estradiol valerate, inform your healthcare provider or pharmacist about any known allergies to the medication or other substances. This product may contain inactive ingredients that can potentially trigger allergic reactions or other adverse effects.

Before commencing the use of this medication, disclose your complete medical history to your doctor or pharmacist, especially if you have a history of vaginal bleeding of unknown origin, certain types of cancers, blood clotting disorders, stroke, heart disease, liver disease, kidney disease, a family history of breast abnormalities, cancer, or blood clots, a personal or family history of a specific swelling disorder known as angioedema, blood clotting disorders such as protein C or protein S deficiency, high blood pressure, diabetes, elevated levels of blood cholesterol or triglycerides, obesity, lupus, underactive thyroid (hypothyroidism), imbalances in mineral levels, a particular hormone disorder called hypoparathyroidism, uterus-related issues, gallbladder disease, asthma, seizures, migraine headaches, a specific blood disorder known as porphyria, or mental/mood disorders.

Refrain from smoking or using tobacco products while using this medication. Combining estrogens with smoking further escalates the risk of stroke, blood clot formation, high blood pressure, and heart attack, particularly in women aged 35 years or older.

Inform your doctor if you have recently undergone surgery or if you will be immobile for an extended period, such as during a long plane flight or bed rest. These conditions heighten the likelihood of developing blood clots, particularly when using estrogen-based products. It may be necessary to discontinue this medication temporarily or take special precautions as advised by your healthcare provider.

This medication may cause the development of patchy, dark areas on the face and skin known as melasma. Sunlight exposure can exacerbate this effect. Limit your time in the sun, avoid tanning booths and sunlamps, and ensure the use of sunscreen and protective clothing when outdoors.

Individuals who are nearsighted or wear contact lenses may experience vision problems or difficulties wearing their lenses while using this medication. In the event of such issues, consult an eye doctor.

Children may exhibit increased sensitivity to the side effects of this medication, which can potentially affect their growth and development. Discuss the potential effects of this medication with the doctor and regularly monitor your child’s growth.

This medication should not be used during pregnancy. If you become pregnant or suspect that you may be pregnant, promptly inform your doctor.

This medication is excreted into breast milk and may reduce the quality and quantity of breast milk produced. Consult your doctor before breastfeeding while using this medication.

Form and Strength

Delestrogen is available in the following forms and strengths:

  • Delestrogen vial:

    • 20mg/ml


What is Delestrogen used for in men?

Some forms of estradiol injection are used in men to treat the symptoms of prostate cancer.

Do Delestrogen injections make you tired?

You may feel more tired when you are taking hormone therapy.



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Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Delestrogen (Estradiol). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Delestrogen (Estradiol).