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Formulation : 
Description
Indications
This product is designed to manage and prevent symptoms, such as wheezing and shortness of breath, associated with ongoing lung diseases like chronic obstructive pulmonary disease (COPD). Effectively controlling these breathing-related symptoms enables individuals to maintain an active lifestyle.
Comprising two medications, aclidinium and formoterol, this inhaler works by inducing relaxation in the muscles surrounding the airways, facilitating their opening and promoting easier breathing. Aclidinium falls into the category of anticholinergics, while formoterol is classified as a long-acting beta agonist (LABA). Both medications are effective bronchodilators.
Uses and Dosage
Inhale this medication orally as directed by your doctor, typically twice daily – once in the morning and once in the evening. You may or may not detect the taste of the drug during inhalation. Avoid exhaling into the device and prevent any contact with your eyes.
Consistently use this medication to derive the maximum benefit. To facilitate adherence, administer it at the same times each day.
Do not alter your dosage, increase the frequency of use, or discontinue the medication without consulting your doctor first. Such adjustments will not expedite improvement, and they may heighten the risk of side effects.
If you are concurrently using other inhalers, ensure a minimum interval of 1 minute between the usage of each medication.
If you have been following a regular daily schedule with a quick-relief inhaler (e.g., albuterol or salbutamol), such as using it four times daily, you must discontinue this schedule. Use the quick-relief inhaler only as needed for sudden shortness of breath, and consult your doctor for guidance.
Understand which inhalers to use on a daily basis and which to use if your breathing suddenly worsens (quick-relief drugs). Seek advice from your doctor in advance on what steps to take if you experience a new or worsening cough, shortness of breath, wheezing, increased sputum, or difficulty breathing at night. Be aware of when to self-manage sudden breathing problems and when to seek immediate medical assistance.
Side Effects
Some side effects may occur that usually do not need medical attention:
- bone pain
- difficulty in moving
- dry mouth
- mouth or throat pain
- muscle stiffness
- toothache
Inform your healthcare provider immediately if you experience any serious side effects:
- chills
- cough
- difficulty in breathing
- ear congestion
- fever
- headache
- loss of voice
- runny or stuffy nose
- sneezing
- sore throat
- unusual tiredness or weakness
- bladder pain
- bloody or cloudy urine
- diarrhea
- difficult, burning, or painful urination
- frequent urge to urinate
Caution
- Before using aclidinium/formoterol, inform your doctor or pharmacist about any allergies you may have to either drug or any other substances. This product may include inactive ingredients, such as milk proteins, which can potentially trigger allergic reactions or other complications.
- Share your medical history with your doctor or pharmacist, especially if you have a history of heart problems, high blood pressure, seizures, overactive thyroid, diabetes, personal or family history of glaucoma, difficulty urinating, or a certain adrenal gland tumor (pheochromocytoma).
- Aclidinium/formoterol may lead to a condition affecting heart rhythm (QT prolongation), which can rarely result in serious (and rarely fatal) fast/irregular heartbeat and other symptoms, such as severe dizziness or fainting, requiring immediate medical attention.
- The risk of QT prolongation may be elevated if you have specific medical conditions or are taking other drugs that may cause QT prolongation. Before using aclidinium/formoterol, inform your doctor or pharmacist about all the drugs you are taking and if you have any of the following conditions: certain heart problems, or a family history of certain heart problems.
- Low levels of potassium or magnesium in the blood may also increase the risk of QT prolongation. This risk may rise if you use certain drugs (such as diuretics/”water pills”) or if you have conditions like severe sweating, diarrhea, or vomiting. Discuss the safe use of aclidinium/formoterol with your doctor.
- Older adults may be more sensitive to the side effects of this drug, especially QT prolongation.
- During pregnancy, use this medication only when clearly necessary. Discuss the associated risks and benefits with your doctor.
- The passage of this medication into breast milk is unknown. Consult your doctor before breastfeeding.
Form and Strength
Duaklir Pressair is available in the following forms and strengths:
- Duaklir Pressair inhalation powder:
- 400 / 12 mcg
FAQ
How quickly does Duaklir Pressair work?
Duaklir Pressair reaches peak levels in your body within 5 minutes after the first dose. You can feel your lungs work better and breathe easier for up to 12 hours.
When is the best time to use Duaklir Pressair?
Duaklir Pressair should be used twice daily for long-term treatment. It’s recommended to use 1 puff in the morning and 1 puff in the evening around the same time every day.
Resources
- https://www.goodrx.com/duaklir-pressair/what-is#faqs
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210595lbl.pdf
- https://www.mayoclinic.org/drugs-supplements/aclidinium-and-formoterol-inhalation-route/side-effects/drg-20461317?
- https://www.webmd.com/drugs/2/drug-178032/duaklir-pressair-inhalation/details
- https://www.drugs.com/duaklir-pressair.html
