Prescription Required 
Formulation : 
Description
Indications
Hyaluronic acid injections are employed to alleviate knee discomfort stemming from osteoarthritis (OA) in individuals who have previously tried conventional pain relievers (e.g., acetaminophen) and other therapies with limited success.
Hyaluronic acid closely mimics a naturally occurring substance within the joints. Its mechanism involves functioning as a lubricant and cushion within the joints, facilitating proper joint functionality.
Uses and Dosage
This medication is administered via injection into the affected joint by a healthcare professional, following your doctor’s instructions, typically once a week.
The dosage is tailored to your medical condition and response to treatment.
Prior to injection, excess fluid may be extracted from the joint.
Avoid using skin disinfectants containing ammonium salts, like benzalkonium chloride, for preparing the injection site. Hyaluronic acid should not be injected into a vein or artery to prevent heightened side effects.
Following hyaluronic acid injection, refrain from activities stressing the knee (e.g., jogging, tennis, heavy lifting, prolonged standing) for 48 hours. Initially, you may experience heightened pain and swelling at the injection site. If these symptoms persist or worsen, promptly consult your doctor.
Adhering to the injection schedule is vital for optimal results, often requiring up to 3 injections before experiencing the full benefits.
Inform your doctor if your condition persists or worsens.
Side Effects
Some side effects may occur that usually do not need medical attention:
- warmth, pain, redness, stiffness, bruising, or puffiness where the medicine was injected
- nausea, stomach pain
- trouble walking
- swelling in your hands or feet
- back pain, joint pain, muscle pain
- numbness or tingly feeling
- headache
- dizziness
Inform your healthcare provider immediately if you experience any serious side effects:
- severe pain or swelling around the knee after the injection
- difficulty with moving
- muscle pain or stiffness
- pain in the joints
Caution
- Before using hyaluronate, inform your doctor or pharmacist about any allergies you have, including allergies to hyaluronate itself or other substances. For certain brands, also disclose any allergies to bird proteins, feathers, or egg products, as some formulations may contain these components. Be aware that inactive ingredients in the product, such as latex present in the rubber syringe cap of certain brands, could trigger allergic reactions or other complications.
- Prior to using this medication, discuss your medical history with your doctor or pharmacist, particularly if you have a history of knee joint infections, skin infections or problems in the injection site area, or circulation issues in the legs.
- During pregnancy, only use this medication if clearly necessary. Discuss the potential risks and benefits with your doctor.
- It’s uncertain whether this drug passes into breast milk. Consult your doctor before breastfeeding.
Form and Strength
Durolane is available in the following forms and strengths:
- Durolane injection:
- 60 mg / 3 mL
FAQ
Can I walk immediately after receiving a Durolane injection?
Yes, patients can generally walk immediately after receiving a Durolane injection. However, it is important to follow the advice of your healthcare professional, who may recommend taking it easy for a day or two after the treatment.
Is Durolane classified as a gel-type injection?
Yes, Durolane is classified as a gel-type injection. It is a purified form of hyaluronic acid used to lubricate and act as a shock absorber in the joints, providing symptomatic relief for mild to moderate osteoarthritis.
Resources
- https://mymskclinic.co.uk/durolane-injection/
- https://my.clevelandclinic.org/health/articles/22915-hyaluronic-acid
- https://www.mayoclinic.org/drugs-supplements/hyaluronic-acid-injection-route/side-effects/drg-20074557
- https://www.webmd.com/osteoarthritis/hyaluronic-acid-injections-for-osteoarthritis
- https://www.webmd.com/vitamins/ai/ingredientmono-1062/hyaluronic-acid
- https://www.drugs.com/mtm/durolane-injection.html#uses
