Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin) Customer Reviews

Tri-Luma Cream

Rx Prescription Required    RxFormulation : Cream

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Tri-Luma Cream is a topical therapy for short-term treatment of dark spots related to moderate-to-severe facial melasma. 

This drug consists of a triple-combination of active ingredients: Fluocinolone, an anti-inflammatory and anti-swelling steroid; Hydroquinone, a bleaching agent for the skin; and Tretinoin, a kind of vitamin A that aids the skin’s natural renewal process. 

Tri-Luma cream for melasma is recommended only for short-term (up to 8 weeks) treatment of melasma of the face, in combination with sun protection like the use of sunscreen.

What is Tri-Luma cream used for?  

  • Tri-Luma for hyperpigmentation treatment is an everyday use of this medication. However, if skin darkening is caused by conditions other than melasma, consult a doctor specializing in the skin for options that are suitable for your condition. 
  • Tri-Luma is often used to treat melasma for a brief period of time and not for long-term skincare.


  • Once a day, at least 30 minutes before bedtime, this is administered. Pay attention to your doctor’s directions. 
  • Before using this drug, wash your face gently with a light cleanser. Rinse skin and pat it dry. 
  • Apply a thin layer of medication to the melasma-affected skin and roughly 1/2 inch of surrounding skin. Keep the medicine away from the lips and wrinkles of your nose. 
  • Do not use a bandage to cover the treated skin since this can increase the quantity of medication absorbed through your skin, which might have negative consequences.
  • After administering the drug, wash your hands.

Tri-Luma Cream Side Effects 

Some of the most prevalent side effects are as follows: 

  • Acne; or
  • Your skin may show signs of minor redness, burning, itching, dryness, or peeling.


  • Tell your doctor if you are allergic to fluocinolone/tretinoin/hydroquinone, other corticosteroids, vitamin A-related medicines (e.g., isotretinoin), or any other allergies before using it. Consult your doctor or pharmacist for more information. 
  • Tell your doctor your medical history, especially if you have asthma, open sores or broken skin (especially on the face), or other skin conditions (e.g., eczema, psoriasis) before taking this medication.
  • In rare situations, excessive skin bleaching may occur, resulting in an unfavorable aesthetic impact in people with darker skin.
  • Effects of too much corticosteroid medicine may be more pronounced in children. Though it is extremely unusual with corticosteroids applied to the skin, if administered for an extended length of time, this may temporarily reduce a child’s pace of growth. However, it is unlikely to have an impact on adult height. Keep track of your child’s height regularly.

Frequently Asked Questions 

-Does Tri-luma need to be refrigerated?  

This must be kept refrigerated in a colorized temperature mode, between 2 and 8 degrees Celsius. 

-How long does it take for Tri-Luma to start working? 

You can notice improvement between four to eight weeks from the use of this drug. If no result is seen, consult your doctor since this is not intended for long-term use. 

Additional information

Generic name:






Quantities Available:

30g, 60g

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin).