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Formulation : 
Description
Indications
The combination of enalapril and hydrochlorothiazide is employed in the treatment of high blood pressure. Enalapril belongs to the class of medications known as angiotensin-converting enzyme (ACE) inhibitors. Its mechanism of action involves the reduction of specific chemicals that constrict blood vessels, promoting smoother blood flow.
Hydrochlorothiazide, on the other hand, falls under the category of diuretics, commonly referred to as ‘water pills.’ It operates by prompting the kidneys to eliminate excess water and salt from the body, facilitating their excretion through urine. The synergistic effect of enalapril and hydrochlorothiazide helps manage high blood pressure by addressing different aspects of blood vessel constriction and fluid balance.
Uses and Dosage
Take this medication orally, with or without food, as directed by your doctor, usually once daily. If taken too close to bedtime, it may lead to an increased need to wake up for urination. For optimal results, it’s recommended to take this medication at least 4 hours before bedtime.
If you are concurrently using cholestyramine or colestipol, ensure a time gap of at least 4 hours before or after taking enalapril/hydrochlorothiazide in relation to these medications.
The dosage is determined by your medical condition and response to treatment. Take this medication consistently at the same time each day to maximize its benefits. It may take several weeks before experiencing the full advantages of this medication. Continue taking it even if you feel well, as high blood pressure often presents no noticeable symptoms.
Keep your doctor informed if your condition does not improve or worsens, indicated by sustained or increased blood pressure readings. Regular communication with your healthcare provider is essential for optimal management of your health.
Side Effects
Some side effects may occur that usually do not need medical attention:
- cough
- dizziness
- headache
- excessive tiredness
- muscle cramps
- decrease in sexual ability
Inform your healthcare provider immediately if you experience any serious side effects:
- lightheadedness
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- hoarseness
- difficulty breathing or swallowing
- fever, sore throat, chills, and other signs of infection
- yellowing of the skin or eyes
- dry mouth
- thirst
- weakness
- infrequent urination
- upset stomach
- vomiting
- fainting
- chest pain
- fast or irregular heartbeat
Caution
- Before taking this product, inform your doctor or pharmacist if you are allergic to enalapril, hydrochlorothiazide, other ACE inhibitors (such as captopril, lisinopril), other thiazides (such as chlorothiazide), or if you have any other allergies. Inactive ingredients in the product may cause allergic reactions or other complications.
- Before using this medication, disclose your medical history to your doctor or pharmacist, especially if you have a history of an allergic reaction involving swelling of the face/lips/tongue/throat (angioedema), kidney disease, liver disease, lupus, gout, untreated salt imbalance, dehydration, or if you have undergone blood filtering procedures (such as LDL apheresis, dialysis), or have a history of skin cancer.
- This medication may cause dizziness. Alcohol or marijuana can enhance this effect. Refrain from driving, using machinery, or engaging in activities requiring alertness until you can do so safely.
- Severe sweating, diarrhea, or vomiting can lead to dehydration and lightheadedness. Inform your doctor if you experience severe diarrhea or vomiting. To prevent dehydration, ensure you drink plenty of fluids unless advised otherwise by your doctor.
- Enalapril/hydrochlorothiazide may increase your sensitivity to the sun and raise the risk of skin cancer, particularly with prolonged use. Limit sun exposure, avoid tanning booths and sunlamps, and use sunscreen and protective clothing outdoors. Notify your doctor promptly if you experience sunburn, skin blisters/redness, or observe new or changed moles/skin lesions.
- This product may affect potassium levels. Consult your doctor before using potassium supplements or salt substitutes containing potassium.
- For individuals with diabetes, this product may impact blood sugar levels. Monitor your blood sugar regularly as directed and share the results with your doctor. Inform your doctor promptly if you experience symptoms of high or low blood sugar.
- Adjustments to your diabetes medication, exercise program, or diet may be necessary.
- Older adults may be more sensitive to side effects, particularly dizziness and changes in urine output (indicative of kidney problems).
- Notify your doctor if you are pregnant or planning to become pregnant. Avoid becoming pregnant while using enalapril/hydrochlorothiazide, as it may harm an unborn baby. In case of pregnancy, discuss the risks and benefits with your doctor promptly.
- This product passes into breast milk, but it is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.
Form and Strength
Vaseretic is available in the following forms and strengths:
- Vaseretic tablet:
- 10 / 25 mg
- hydrochlorothiazide and enalapril tablet:
- 5 /12.5 mg
- 10 / 25 mg
FAQ
How long does it take for Vaseretic to work?
Vaseretic starts to kick in within 1 hour, but it can take 4 to 6 hours for the medication to be fully absorbed by the body. It can take a few weeks of using Vaseretic for it to fully kick in and give consistent results.
Does Vaseretic cause weight loss?
Vaseretic is not a weight loss medication. The hydrochlorothiazide (water pill) that is in this combo medication causes you to urinate more to get rid of extra fluid in your body. This can cause weight loss, but this is water weight and not fat loss.
Resources
- https://www.goodrx.com/vaseretic/what-is#faqs
- https://www.mayoclinic.org/drugs-supplements/enalapril-and-hydrochlorothiazide-oral-route/description/drg-20069149
- https://www.webmd.com/drugs/2/drug-7120/vaseretic-oral/details
- https://medlineplus.gov/druginfo/meds/a601047.html
- https://www.drugs.com/mtm/vaseretic-10-25.html
