Prescription Required 
Formulation : 
Description
Indications
Ophthalmic lifitegrast is prescribed for alleviating the signs and symptoms associated with dry eye disease. Classified as a lymphocyte function-associated antigen-1 (LFA-1) antagonist, lifitegrast operates by diminishing inflammation in the tissues of the eye.
Uses and Dosage
Ophthalmic lifitegrast is provided in liquid form as a solution for instillation into the eyes. Typically, it is administered twice daily, with each application spaced approximately 12 hours apart. It’s essential to instill lifitegrast consistently at around the same times every day.
Follow the prescribed dosage precisely; avoid using more or less than instructed or using it more frequently than directed by your doctor.
Lifitegrast eye drops are packaged in single-use containers, designed for one dose each. Use the liquid from the container immediately upon opening, and discard the container along with any remaining liquid once the application is complete. Do not retain the leftover liquid in the container for the next dose.
To administer the eye drops, the following steps should be followed:
- Thoroughly wash hands with soap and water.
- Do not allow the dropper tip to touch the eye or any other surface, and ensure that it is kept clean.
- Tilt the head back and pull down the lower lid of the eye using the index finger to form a pocket.
- Hold the dropper as close to the eye as possible without making contact, and brace the remaining fingers against the face.
- Squeeze the dropper gently to instill a single drop in the pocket created by the lower eyelid while looking upwards.
- Remove the index finger from the lower eyelid and keep the eye closed for 2-3 minutes while tilting the head down.
- Apply gentle pressure to the tear duct using a finger.
- Use a tissue to wipe off any excess liquid from the face.
- Wash hands to remove any residual medication.
Side Effects
Some side effects may occur that usually do not need medical attention:
- change in taste
- loss of taste
- cough
- discomfort or itching of the eyes
- drainage from the eyes
- fever
- headache
- pain or tenderness around the eyes and cheekbones
Inform your healthcare provider immediately if you experience any serious side effects:
- shanges in vision
- severe eye irritation or discomfort
- blurred vision
- redness of the white part of the eyes or inside of the eyelids
Caution
- Prior to using lifitegrast, inform your doctor or pharmacist about any known allergies to this medication or if you have any other allergies. The product may contain inactive ingredients that could trigger allergic reactions or other complications.
- Discuss your medical history with your doctor or pharmacist before initiating the use of this medication.
- After applying this drug, be aware that your vision may experience temporary blurring. Refrain from driving, operating machinery, or engaging in activities that demand clear vision until you can do so safely.
- If you are pregnant, use this medication only if it is deemed necessary after thorough discussion of the risks and benefits with your doctor.
- The passage of this drug into breast milk is not well-established. Prior to breastfeeding, consult with your doctor for guidance.
Form and Strength
Xiidra Ophthalmic Solution is available in the following forms and strengths:
- Xiidra Ophthalmic Solution eyedrops:
- 5 %
FAQ
How long does it take for Xiidra to start working?
In clinical studies, Xiidra was shown to provide relief of symptoms of eye dryness for some patients in as little as 2 weeks of use. Many patients observed improvements in symptoms at 6 weeks or 12 weeks.
Does Xiidra need to be refrigerated?
You should store Xiidra eye drops at room temperature.
Resources
- https://www.xiidra.com/time-to-efficacy#:~:text=In%20clinical%20studies%2C%20Xiidra%20was,6%20weeks%20or%2012%20weeks
- https://www.healthline.com/health/drugs/xiidra#fa-qs
- https://www.mayoclinic.org/drugs-supplements/lifitegrast-ophthalmic-route/side-effects/drg-20312356
- https://www.webmd.com/drugs/2/drug-172164/xiidra-ophthalmic-eye/details
- https://medlineplus.gov/druginfo/meds/a616039.html
- https://www.drugs.com/xiidra.html
