Zaroxolyn (Metolazone) Customer Reviews


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Generic alternative for Zaroxolyn


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Metolazone is employed to alleviate swelling and fluid retention stemming from conditions like heart failure or kidney disease. It may also be prescribed as a standalone treatment or in conjunction with other medications to manage high blood pressure. Metolazone belongs to a category of drugs known as diuretics, commonly referred to as “water pills.” These medications prompt the kidneys to decrease the levels of water and salt in the body by augmenting urine production.

Uses and Dosage

Take this medication orally, with or without food, following your doctor’s instructions, typically once daily. The prescribed dosage depends on your medical condition and how you respond to the treatment.

If you ingest this medication too close to bedtime, you might need to wake up during the night to urinate. Take this medication at least 4 hours before your bedtime.

To derive the maximum benefit from this medication, use it consistently and at the same time each day, as directed. Even if you start feeling better, continue taking this medication. Most individuals with high blood pressure don’t experience noticeable symptoms.

Refrain from discontinuing this medication without consulting your doctor, as it may take anywhere from 3 to 6 weeks to observe a reduction in your blood pressure.

Cholestyramine and colestipol can interfere with the absorption of metolazone. If you are using any of these drugs, ensure you separate metolazone from cholestyramine by at least 4 hours and from colestipol by at least 2 hours.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • dizziness
  • weakness
  • restlessness
  • headache
  • muscle cramps
  • joint pain or swelling
  • constipation
  • diarrhea

Inform your healthcare provider immediately if you experience any serious side effects:

  • chest pain
  • rapid, irregular, or pounding heartbeats
  • hives
  • rash
  • itching
  • blistering or peeling skin
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • hoarseness
  • difficulty swallowing or breathing
  • sore throat with fever
  • unusual bleeding or bruising
  • upset stomach
  • extreme tiredness
  • loss of appetite
  • pain in the upper right part of the stomach
  • yellowing of the skin or eyes


Before you begin taking metolazone, inform your doctor or pharmacist about any allergies you may have. This product could contain inactive components that may cause allergic reactions or other complications.

Before using this medication, it’s important to share your medical history with your doctor or pharmacist, particularly if you have a history of kidney disease, liver disease, untreated mineral imbalances, gout, or lupus.

For individuals with diabetes, metolazone may impact blood sugar levels. Regularly monitor your blood sugar as instructed and share the results with your doctor. Promptly inform your doctor if you experience symptoms of high blood sugar, such as increased thirst or urination. Your doctor may need to adjust your diabetes medication, exercise regimen, or dietary plan.

This medication may lower potassium levels in your bloodstream. Consult your doctor about incorporating more potassium into your diet, and if necessary, your doctor may prescribe a potassium supplement.

Metolazone might increase your sensitivity to sunlight. Limit your exposure to the sun, avoid tanning beds and sunlamps, and when outdoors, use sunscreen and wear protective clothing. Notify your doctor immediately if you experience sunburn or skin blistering/redness.

This drug could induce dizziness or blurred vision. Alcohol or marijuana can exacerbate these effects. Refrain from driving, operating machinery, or engaging in tasks that require alertness or clear vision until you can do so safely.

To reduce the risk of dizziness and lightheadedness, rise slowly when transitioning from sitting or lying down, especially for older adults who may be more susceptible to these side effects.

During pregnancy, metolazone should only be used when absolutely necessary. Discuss the potential risks and benefits with your doctor.

This drug can pass into breast milk. Consult your doctor before breastfeeding.

Form and Strength

Zaroxolyn is available in the following forms and strengths:

  • metolazone tablet:

    • 2.5mg


How long does it take for Zaroxolyn to start working?

It usually takes 3 to 4 days for Zaroxolyn to start reducing edema, and 3 to 6 weeks to start reducing blood pressure.

Should Zaroxolyn be taken in the morning or at night?

It is best to take this medication at least 4 hours before your bedtime.



Additional information

Generic name:





2.5mg, 5mg

Quantities Available:

90, 100

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Zaroxolyn (Metolazone). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Zaroxolyn (Metolazone).