Ziac (Bisoprolol/Hctz) Customer Reviews


Rx Prescription Required    RxFormulation : Tablet

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This combination medication is prescribed for the management of high blood pressure, a condition that can increase the risk of strokes, heart attacks, and kidney issues. This product comprises two distinct medications: Bisoprolol and Hydrochlorothiazide. Bisoprolol, classified as a beta blocker, exerts its effects by inhibiting the action of specific natural substances like epinephrine on the heart and blood vessels. Hydrochlorothiazide is categorized as a “water pill” or diuretic. It functions by increasing the volume of urine produced by your body. This process leads to the elimination of excess salt and water, which is likely to relax blood vessels, facilitating smoother blood flow.

Uses and Dosage

Take this medication by mouth as instructed by your doctor, either with or without food, usually once daily. The appropriate dosage will be determined based on your medical condition and your response to the treatment.

To avoid the need to urinate during the night, do not take this medication within 4 hours of your bedtime. If you have any questions regarding your dosing schedule, don’t hesitate to consult your doctor or pharmacist.

If you are also using cholestyramine or colestipol, time your bisoprolol/hydrochlorothiazide dose at least 4 hours before or 4 to 6 hours after taking either of those medications.

Consistency is key when taking this medication to derive the maximum benefit. To aid in remembering, take it at the same time each day. Continue taking this medication even if you’re feeling well, as high blood pressure often presents no noticeable symptoms. It may take up to 3 weeks to experience the full therapeutic effect of this medication.

Keep your doctor informed if your condition deteriorates, such as an increase in your routine blood pressure readings.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • belching
  • decreased interest in sexual intercourse
  • diarrhea
  • difficulty with moving
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • joint pain
  • loss in sexual ability, desire, drive, or performance
  • muscle aching or stiffness
  • sleepiness
  • stomach discomfort, upset, or pain
  • swollen joints

Inform your healthcare provider immediately if you experience any serious side effects:

  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • chest pain or discomfort
  • lightheadedness, dizziness, or fainting
  • rapid weight gain
  • slow or irregular heartbeat
  • tingling of the hands or feet
  • trouble breathing
  • unusual tiredness or weakness
  • unusual weight gain or loss


Before starting this medication, inform your doctor or pharmacist of any allergies you may have, whether it’s to bisoprolol, hydrochlorothiazide, other beta blockers like metoprolol or atenolol, thiazide diuretics such as chlorothiazide, or any other allergens. Inactive ingredients present in the product can also potentially trigger allergic reactions or other adverse effects.

Share your medical history with your doctor or pharmacist, particularly if you have a history of kidney disease, liver disease, specific types of heart rhythm issues, heart failure, lung conditions, hyperthyroidism, diabetes, gout, untreated imbalances in salts, dehydration, circulatory problems, certain muscle disorders, lupus, recent nerve surgeries, or a history of skin cancer.

This medication may cause dizziness or drowsiness, which can be exacerbated by alcohol or marijuana. Avoid activities requiring alertness, like driving or operating machinery, when taking this drug.

To prevent dizziness, stay well-hydrated while on this medication, especially in hot weather or during heavy exercise. Prolonged diarrhea or vomiting should be reported to your doctor.

The medication may mask the typical fast or pounding heartbeat associated with low blood sugar levels (hypoglycemia). This risk is more significant for individuals with diabetes, those who are vomiting, fasting, or not eating regularly. Other symptoms of low blood sugar, such as dizziness and sweating, are unaffected by this medication.

If you have diabetes, this drug may make blood sugar level control more challenging. Regularly check your blood sugar levels as directed by your physician and report symptoms of high blood sugar, such as increased thirst and urination, promptly. Adjustments to your diabetes treatment, exercise regimen, or diet may be necessary.

This medication might reduce potassium levels in your bloodstream. Consult your doctor regarding potassium supplementation. They may prescribe a potassium supplement.

The drug may increase your sensitivity to sunlight and potentially elevate the risk of skin cancer, especially with long-term use. Minimize sun exposure, avoid tanning beds and sunlamps, and wear protective clothing and sunscreen when outdoors. Notify your doctor if you experience sunburn or observe skin blisters, redness, or changes in moles or skin lesions.

During pregnancy, use this medication only when the benefits outweigh the risks, and consult with your doctor about the best course of action.

This drug passes into breast milk and may have adverse effects on nursing infants. Consult your doctor before breastfeeding.

Form and Strength

Ziac is available in the following forms and strengths:

  • Ziac tablet:

    • 5/6.25mg


How long does it take for Ziac to work?

Ziac starts to kick in within about 4 hours. However, it can take up to 3 weeks of taking Ziac regularly before you can see the maximum effect on your blood pressure.

What is the best time of day to take Ziac?

Because this medication contains a diuretic, it’s usually better to take it earlier during the day to avoid waking up in the middle of the night to use the bathroom.


  1. https://www.goodrx.com/ziac/what-is#faqs
  2. https://www.mayoclinic.org/drugs-supplements/bisoprolol-and-hydrochlorothiazide-oral-route/side-effects/drg-20071051?p=1
  3. https://www.webmd.com/drugs/2/drug-16200/ziac-oral/details
  4. https://www.rxlist.com/ziac-drug.htm
  5. https://www.drugs.com/ziac.html

Additional information

Generic name:






Quantities Available:

30, 90

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Ziac (Bisoprolol/Hctz). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Ziac (Bisoprolol/Hctz).