Aklief Cream (Trifarotene) Customer Reviews

Aklief Cream

Rx Prescription Required    RxFormulation : Cream

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Trifarotene is indicated for the treatment of acne. It possesses the ability to reduce the quantity and severity of acne lesions, whilst accelerating the healing process of the ones that do emerge. Classified as a member of the retinoid medication class, trifarotene operates by modulating cellular growth whilst simultaneously reducing inflammation and edema.

Uses and Dosage

Trifarotene cream is intended for topical application and is typically administered once daily at bedtime. The instructions on the prescription label should be followed meticulously. Adherence to the prescribed dosage is imperative, and neither more nor less than the prescribed amount should be applied.

Trifarotene cream is intended for use exclusively on the face (forehead, nose, cheeks, chin) or upper trunk (upper back, chest, and shoulders). Avoid contact with the eyes, ears, mouth, corners along the nose, or vaginal area. The cream should not be applied to areas with cuts, abrasions, sunburns, or eczema.

Trifarotene cream is dispensed in a pump bottle, with accompanying instructions for proper use. Before application, the affected skin should be gently cleaned and thoroughly dried. The cream should then be applied thinly to the affected skin on the face, chest, shoulders, or back. If there are any uncertainties about the proper application, the doctor or pharmacist should be consulted.

Trifarotene cream should not be used concurrently with nonmedicated or medicated cosmetics, abrasive products, or cleansers containing alcohol.

During the initial four weeks of treatment, the skin may become dry or irritated. If the skin stings, burns, or becomes irritated at any point during the treatment, medical advice should be sought. The prescribing doctor may recommend the use of a moisturizer to alleviate dryness or suggest that the cream is applied less frequently.

Side Effects

Some side effects may occur that usually do not need medical attention:

  • burning
  • dryness
  • loss of skin pigment
  • peeling
  • skin redness
  • stinging


Prior to utilizing trifarotene, inform your healthcare provider or pharmacist if you have any allergies to the drug or to vitamin A-related medications (e.g., tretinoin) or if you have any other known allergies. Inactive components present in the product may trigger an allergic response or other complications.

Before using this medication, notify your healthcare provider or pharmacist of your medical history, particularly if you have a history of eczema.

This medication has the potential to increase your susceptibility to the sun. As a precautionary measure, limit sun exposure, avoid tanning booths and sunlamps, and wear protective clothing and sunscreen while outside. If you experience sunburn or skin blistering/redness, inform your doctor right away.

While using this product, refrain from undergoing hair removal procedures such as electrolysis, waxing, or chemical depilatories in the treated regions.

If you have recently used products containing sulfur, resorcinol, or salicylic acid, exercise caution when using trifarotene. Wait until the effects of these products on the skin have subsided before using trifarotene.

During pregnancy, trifarotene should only be used when absolutely necessary. This medication may be detrimental to a developing fetus, and the potential risks and benefits should be discussed with a healthcare provider.

It is unknown if this medication passes into breast milk. Prior to breast-feeding, consult with a healthcare provider. If using trifarotene while breast-feeding, avoid applying it to the nipples or areolas.

Form and Strength

Aklief Cream is available in the following forms and strengths:

  • Aklief Cream cream:

    • 50mcg/g


Does Aklief Cream get rid of acne scars?

No, Aklief hasn’t been shown to treat current acne scars. But using Aklief may help prevent future scars from forming.

How long does it take for Aklief Cream to work?

You may notice your facial acne improving as early as 2 weeks.


  1. https://www.medicalnewstoday.com/articles/drugs-aklief#fa-qs
  2. https://www.aklief.com/why-aklief-cream#:~:text=using%20AKLIEF%20Cream%3F-,%E2%80%8C,AKLIEF%20Cream%20for%2012%20weeks.&text=You%20should%20continue%20with%20your%20treatment%20as%20your%20dermatology%20provider%20directed
  3. https://www.medbroadcast.com/drug/getdrug/aklief#adverseeffects
  4. https://www.webmd.com/drugs/2/drug-178088/aklief-topical/details
  5. https://medlineplus.gov/druginfo/meds/a620004.html
  6. https://www.drugs.com/aklief.html

Additional information

Generic name:






Quantities Available:

75 grams, 150 grams

Can Drug Store has provided information from third parties intended to increase awareness and does not contain all the information about Aklief Cream (Trifarotene). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Aklief Cream (Trifarotene).